Results 171 to 180 of about 452,381 (401)

Interconnected pathways and emerging therapies in chronic kidney disease and heart failure: A comprehensive review

ESC Heart Failure, EarlyView.
Abstract Chronic kidney disease (CKD) and chronic heart failure (HF) frequently coexist and, when comorbid, are associated with poorer outcomes. These two diseases have common risk factors, such as diabetes, obesity and hypertension, and common pathophysiological connected mechanisms, including inflammation, endothelial dysfunction, neurohormonal ...
Johann Bauersachs, Eri Toda Kato, Janani Rangaswami   +2 more
wiley   +1 more source

Canagliflozin reduces oral loop diuretic intensification in patients with type 2 diabetes: A participant‐level pooled analysis of the CANVAS and CREDENCE trials

European Journal of Heart Failure, EarlyView.
Among high‐risk patients with T2D, new oral loop diuretic intensification was frequent and portended adverse prognostic significance. Treatment with canagliflozin significantly reduced the need for loop diuretic intensification. ABSTRACT Aims The sodium–glucose cotransporter 2 inhibitor canagliflozin reduces the risk of heart failure (HF ...
Safia Chatur, Muthiah Vaduganathan, Robert A. Fletcher, Vlado Perkovic, Hiddo Heerspink, Clare Arnott, Carol Pollock, Kenneth W. Mahaffey, Bruce Neal, Meg Jardine, Scott D. Solomon, Brendon L. Neuen   +11 more
wiley   +1 more source

Albuminuria as a diagnostic criterion and a therapeutic target in heart failure and other cardiovascular disease

European Journal of Heart Failure, EarlyView.
The value of uACR. CKD, chronic kidney disease; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; uACR, urine albumin‐to‐creatinine ratio. Abstract The high disease burden and bidirectional relationship of chronic kidney disease (CKD), heart failure (HF) and other cardiovascular disease (CVD) necessitate the need for early ...
Biykem Bozkurt, Patrick Rossignol, Joseph A. Vassalotti   +2 more
wiley   +1 more source

IgA nephropathy

Kidney International, 1995
IgAN is the most common type of glomerulonephritis worldwide, and is found more in men and distinctly less in blacks. It presents with macroscopic hematuria in about 40 to 45% of patients, with microscopic hematuria and proteinuria in about 35 to 40%, and with nephrotic syndrome or acute renal failure in the remainder.
openaire   +3 more sources

Immune Landscape Variation in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Circulation Before and After Plasmapheresis by Single-Cell Transcriptome

Mediators of Inflammation
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of autoimmune diseases characterized by inflammation and destruction of small blood vessels. AAV could be fatal if left untreated.
Youzhou Tang, Qingtai Cao, Jishi Liu, Quan Zhuang   +3 more
doaj   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Analgesic nephropathy [PDF]

Nephrology Dialysis Transplantation, 1996
De Broe, M. E., Elseviers, M. M., Bengtsson, U., Mihatsch, M. J., Molzahn, M., Pommer, W., Ritz, E., Schwarz, A.   +7 more
openaire   +3 more sources

Protective effect of phosphoenolpyruvate carboxykinase 1 on inflammation and fibrotic progression of IgA nephropathy

Renal Failure
Introduction Phosphoenolpyruvate carboxykinase 1 (PCK1) is an essential enzyme of the gluconeogenic pathway, which can affect kidney physiology in various ways.
Ya-yin Tan, Yu-kai Wang, Xiao-mei Luo, Chao-yi Chen, Xue-qi Liu, Xin-ran Liu, Yong-gui Wu   +6 more
doaj   +1 more source

Kidney Injury Molecule-1 (Kim-1) sebagai Biomarker Dini Nefropati Diabetik pada Pasien Diabetes Melitus Tipe 2 [PDF]

, 2017
Diabetic nephropathy is a chronic complication of type 2 diabetes mellitus (DM). To prevent the onset or progression of nephropathy, a biomarker is needed that can detect kidney problems at an early stage.
Tangkelangi, M. (Marni)
core   +1 more source

Application of Bryophytes to Foods, Food Additives and Phytomedicines

Food Chemistry International, EarlyView.
Little attention has been paid to the bryophytes for use in the human diet, despite the presence of 23,000 species worldwide. (Marchantia polymorpha). ABSTRACT Little attention has been paid to the bryophytes for application on the human diet, despite the presence of 23,000 species worldwide.
Yoshinori Asakawa, Jianbo Xiao
wiley   +1 more source