Results 51 to 60 of about 3,743 (224)

Icaritin Ameliorates Cisplatin‐Induced Mitochondrial Metabolic Dysfunction‐Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy

Advanced Science, Volume 13, Issue 7, 3 February 2026.
In this study, scRNA‐seq and chemoproteomics are integrated to characterize CDDP‐bound proteins at single‐cell resolution in tumor‐bearing mice. Additionally, the research demonstrates that ICA alleviates CDDP‐induced nephrotoxicity while enhancing its chemotherapeutic efficacy.
Piao Luo, Junhui Chen, Yehai An, Kun Meng, Wei Zhou, Wenhui Li, Jing Liu, Wentong Zhao, Weiyi He, Ting Cao, Jingnan Huang, Sha Feng, Shiguang Yang, Hongling Hu, Jiaxian Liao, Hengkai He, Mingjing Hao, Qian Zhang, Jigang Wang, Yue Gao   +19 more
wiley   +1 more source

Long-term prognosis after acute kidney injury requiring renal replacement therapy [PDF]

, 2017
Background. Data on the long-term survival and renal function of patients with acute kidney injury (AKI) treated with continuous renal replacement therapy are scarce. Methods.
Martin, Pierre-Yves, Perneger, Thomas, Pugin, Jerome, Romand, Jacques, Saudan, Patrick, Triverio, Pierre-Alain   +5 more
core  

Sphingosine 1-phosphate in renal diseases [PDF]

, 2013
Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for the treatment of several diseases. Since the expression of sphingosine kinases as well as S1P receptors was demonstrated in the kidney, questions about ...
Huwiler, Andrea, Koch, Alexander, Pfeilschifter, Josef Martin   +2 more
core   +2 more sources

Flavonoids in Treatment of Chronic Kidney Disease

Molecules, 2022
Chronic kidney disease (CKD) is a progressive systemic disease, which changes the function and structure of the kidneys irreversibly over months or years.
Yi-Ling Cao, Ji-Hong Lin, Hans-Peter Hammes, Chun Zhang   +3 more
doaj   +1 more source

Nephroprotective Effects of Metformin in Diabetic Nephropathy

Journal of Cellular Physiology, 2016
Metformin, a well‐known anti‐diabetic agent, is very effective in lowering blood glucose in patients with type 2 diabetes with minimal side‐effects. Metformin is also being recommended in the treatment of obesity and polycystic ovary syndrome. Metformin elicits its therapeutic effects mainly via activation of AMP‐activated kinase (AMPK) pathway.
Ravindran, Sreenithya, Kuruvilla, Vinitha, Wilbur, Kerry, Munusamy, Shankar   +3 more
openaire   +4 more sources

Construction of PANoptosis‐Inhibiting Carbonized Polymer Dots via Machine Learning Potential for Mitigating Chemodrug‐Induced Nephrotoxicity

Advanced Science, Volume 13, Issue 12, 27 February 2026.
An enhanced sampling method is developed for molecular dynamics based on trained machine learning force fields to guide the construction of PANoptosis‐inhibiting carbonized polymer dots (Lu‐CDs) derived from a flavonoid compound for treating chemodrug‐induced nephrotoxicity.
Xinchen Liu, Jiaxin Zhang, Xiangyu Yan, Nuo Li, Yu‐Chao Dong, Zihao Wang, Daowei Li, Yong Du, Huan Wang   +8 more
wiley   +1 more source

Control of diabetic nephropathy in male Wistar rats using ethanolic extract of Monodora myristica seeds and its biosynthesized selenium nanoparticles [PDF]

Exploration of Drug Science
Aim: This research utilizes the ethanolic extract from seeds of Monodora myristica and its biosynthesized selenium nanoparticles (SeNPs) for the treatment of diabetic nephropathy (DN) in male Wistar rats.
Babalola Ola Yusuf, Usman Okeme, Akeem Omolaja Akinfenwa, Ibrahim Adeola Moronfolu, Zaynab Abiodun Bisiriyu, Halimat Yusuf Lukman, Olanrenwaju Suleiman Olakunle, Lateefat Bello Abdulfatah, Motunrayo Azeezat Aiwinilomo, Rasheed Bolaji Ibrahim   +9 more
doaj   +1 more source

Renoprotection of Selected Antioxidant-Rich Foods (Water Spinach and Red Grape) and Probiotics in Gentamicin-Induced Nephrotoxicity and Oxidative Stress in Rats

Life, 2022
Objectives: The current study investigated the curative effects of two selected antioxidant-rich foods (water spinach and red grape) and probiotics on the kidney exposed to nephrotoxicity induced by gentamicin. Methods: A total of 30 Wistar Albino female
Sneha Sarwar, Md. Jamal Hossain, Nafis Md. Irfan, Tamima Ahsan, Md. Saidul Arefin, Arebia Rahman, Abdullah Alsubaie, Badr Alharthi, Mayeen Uddin Khandaker, David A. Bradley, Talha Bin Emran, Sheikh Nazrul Islam   +11 more
doaj   +1 more source

Nephroprotective Potential of Olea europaea Leaf Extract Against Combined Noise and Toluene‐Induced Oxidative and Histopathological Renal Injuries in Wistar Rats

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT Noise and toluene are environmental stressors that induce oxidative stress and inflammation, contributing to renal dysfunction. This study evaluated the protective effects of Olea europaea leaf extract (OeLE; 40 mg/kg/day) against combined noise‐ and toluene‐induced nephrotoxicity in Wistar rats.
Takoua Ben Attia, Mabrouk Horchani, Mariem Salhi, Zeineb Dhifallah, Meriem Ksentini, Hichem Ben Jannet, Abada Mhamdi   +6 more
wiley   +1 more source

Methods of renal function assessment in arterial hypertension: the clinical value and practical implementation

Кардиоваскулярная терапия и профилактика, 2009
This literature review is focused on the modern diagnostic methods in pre-clinical renal pathology. The wide prevalence of renal dysfunction in cardiovascular disease (CVD), its role in the stratification of cardiovascular and renal complication risk ...
Zh. D. Kobalava, Yu. V. Kotovskaya, S. V. Villewalde   +2 more
doaj