Results 11 to 20 of about 16,895 (259)

Relevance of Neutrophil Neprilysin in Heart Failure

Cells, 2021
Significant expression of neprilysin (NEP) is found on neutrophils, which present the transmembrane integer form of the enzyme. This study aimed to investigate the relationship of neutrophil transmembrane neprilysin (mNEP) with disease severity, adverse ...
Suriya Prausmüller, Georg Spinka, Henrike Arfsten, Stefanie Stasek, Rene Rettl, Philipp Emanuel Bartko, Georg Goliasch, Guido Strunk, Julia Riebandt, Julia Mascherbauer, Diana Bonderman, Christian Hengstenberg, Martin Hülsmann, Noemi Pavo   +13 more
doaj   +1 more source

Active site mutations change the cleavage specificity of neprilysin. [PDF]

PLoS ONE, 2012
Neprilysin (NEP), a member of the M13 subgroup of the zinc-dependent endopeptidase family is a membrane bound peptidase capable of cleaving a variety of physiological peptides.
Travis Sexton, Lisa J Hitchcook, David W Rodgers, Luke H Bradley, Louis B Hersh   +4 more
doaj   +1 more source

Serum neprilysin levels are associated with myocardial stunning after ST-elevation myocardial infarction

BMC Cardiovascular Disorders, 2020
Background Left ventricular remodeling following ST-elevation myocardial infarction (STEMI) is associated with poor outcome, including heart failure (HF).
Damien Legallois, Clémence Macquaire, Amir Hodzic, Stéphane Allouche, Ismaïl El Khouakhi, Alain Manrique, Paul Milliez, Eric Saloux, Farzin Beygui   +8 more
doaj   +1 more source

Soluble neprilysin and long-term clinical outcomes in patients with coronary artery disease undergoing percutaneous coronary intervention: a retrospective cohort study

BMC Cardiovascular Disorders, 2020
Background Neprilysin has an essential role in regulating fluid balance and vascular resistance, and neprilysin inhibitors have shown beneficial effects in patients with heart failure.
Ik Jun Choi, Sungmin Lim, Youngdeok Hwang, Dongjae Lee, Won Jik Lee, Kwan Yong Lee, Mi-Jeong Kim, Doo Soo Jeon   +7 more
doaj   +1 more source

Angiotensin Receptor Neprilysin Inhibitor for Functional Mitral Regurgitation

Circulation, 2019
Duk-Hyun Kang, Sung-Ji Park, Geu-Ru Hong
exaly   +3 more sources

Neprilysin in HFrEF: Differential Regulation of Tissue Versus Circulating Neprilysin.

JACC. Basic to translational science, 2020
[Figure: see text] [Figure: see text]
Chen, Horng H., Burnett, John C.
openaire   +3 more sources

Intranasal neprilysin rapidly eliminates amyloid-beta plaques, but causes plaque compensations: the explanation why the amyloid-beta cascade may fail?

Neural Regeneration Research, 2022
Neurodegenerative brain disorders are a major burden in our society, such as Alzheimer´s disease. In order to repair or prevent such diseases, drugs are designed which enter the brain, but the blood-brain barrier limits their entry and the search for ...
Christian Humpel
doaj   +1 more source

Soluble Neprilysin in the General Population: Clinical Determinants and Its Relationship to Cardiovascular Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Neprilysin is a metalloprotease involved in proteolysis of numerous peptides, including natriuretic peptides, and is of prognostic and therapeutic importance in heart failure with reduced ejection fraction.
Yogesh N. V. Reddy, Seethalakshmi R. Iyer, Christopher G. Scott, Richard J. Rodeheffer, Kent Bailey, Gregory Jenkins, Anthony Batzler, Margaret M. Redfield, John C. Burnett, Naveen L. Pereira   +9 more
doaj   +1 more source

Role of Renal Sympathetic Nerves in GLP‐1 (Glucagon‐Like Peptide‐1) Receptor Agonist Exendin‐4‐Mediated Diuresis and Natriuresis in Diet‐Induced Obese Rats

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background The gut‐derived hormone GLP‐1 (glucagon‐like peptide‐1) exerts beneficial effects against established risk factors for chronic kidney disease.
Xuefei Liu, Kaushik P. Patel, Hong Zheng
doaj   +1 more source

Combined drug sacubitril/valsartan -a new era of treatment of chronic heart failure

Медицинский совет, 2020
The article describes the possibility of using a new class of angiotensin II/neprilysin receptor inhibitor - sacubitrile/valsartan for the treatment of chronic heart failure (CHF). The role of the natriuretic peptide system in the pathogenesis of CHF and
V. S. Nikiforov
doaj   +1 more source