Results 11 to 20 of about 25,082 (343)
Relevance of Neutrophil Neprilysin in Heart Failure [PDF]
Cells, 2021 Significant expression of neprilysin (NEP) is found on neutrophils, which present the transmembrane integer form of the enzyme. This study aimed to investigate the relationship of neutrophil transmembrane neprilysin (mNEP) with disease severity, adverse ...
Suriya Prausmüller +13 more
doaj +3 more sources
Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. [PDF]
microPublication biology, 2021 The neprilysin (M13) family of metalloendopeptidases comprises highly conserved ectoenzymes that cleave and thereby inactivate many physiologically relevant peptides in the extracellular space. Impaired neprilysin activity is associated with numerous human diseases.
Meyer, Heiko +5 more
openaire +2 more sources
Frontiers in Aging Neuroscience, 2021 Alzheimer’s disease (AD) is pathologically characterized by extracellular beta-amyloid (Aβ) plaques and intraneuronal tau tangles in the brain. A therapeutic strategy aims to prevent or clear these Aβ plaques and the Aβ-degrading enzyme neprilysin is a ...
Christian Humpel
doaj +1 more source
Circulating Neprilysin Level Predicts the Risk of Cardiovascular Events in Hemodialysis Patients
Frontiers in Cardiovascular Medicine, 2021 Background: Neprilysin inhibition has demonstrated impressive benefits in heart failure treatment, and is the current focus of interest in cardiovascular (CV) and kidney diseases.
Hyeon Seok Hwang +9 more
doaj +1 more source
The immuneregulator role of neprilysin (NEP) in invertebrates [PDF]
Invertebrate Survival Journal, 2012 Neprilysin (NEP) represents an important enzyme in both vertebrates and invertebrates. In the present report we have focused our attention to invertebrates. In particular, a structure related to CD10/NEP as well as its activity in different tissues, such
A. Grimaldi +3 more
core +5 more sources
Soluble neprilysin and survival in critically ill patients
ESC Heart Failure, 2022 Background Critically ill patients admitted to an intensive care unit (ICU) exhibit a high mortality rate irrespective of the initial cause of hospitalization.
Max Lenz +10 more
doaj +1 more source
Plasma Neprilysin Displays No Relevant Association With Neurohumoral Activation in Chronic HFrEF
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background Neprilysin is a transmembrane endopeptidase involved in the breakdown of a variety of vasoactive peptides and serves as a therapeutic target in heart failure with reduced ejection fraction (HFrEF).
Suriya Prausmüller +8 more
doaj +1 more source
JACC: Basic to Translational Science, 2020 [Figure: see text] [Figure: see text]
John C. Burnett, Horng H. Chen
openaire +3 more sources
Urinary neprilysin in the critically ill patient [PDF]
BMC Nephrology, 2017 Critically ill patients in intensive care face hazardous conditions. Among these, acute kidney injury (AKI) is frequently seen as a result of sepsis. Early diagnosis of kidney injury is of the utmost importance in the guidance of interventions or avoidance of treatment-induced kidney injury. On these grounds, we searched for markers that could indicate
Sahra Pajenda +2 more
openalex +4 more sources
Renal effects and associated outcomes during angiotensin-neprilysin inhibition in heart failure [PDF]
, 2018 Objectives: The purpose of this study was to evaluate the renal effects of sacubitril/valsartan in patients with heart failure and reduced ejection fraction.
Claggett, Brian +14 more
core +9 more sources