Results 11 to 20 of about 14,163 (275)
Roles of Natriuretic Peptides and the Significance of Neprilysin in Cardiovascular Diseases
Biology, 2022 Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) activate the guanylyl cyclase A receptor (GC-A), which synthesizes the second messenger cGMP in a wide variety of tissues and cells.
Hitoshi Nakagawa, Yoshihiko Saito
doaj +2 more sources
Unwinding the Interaction of Natriuretic Peptides and Neprilysin∗ [PDF]
Journal of the American College of Cardiology, 2015 Natriuretic peptides are an important aid for the diagnosis of heart failure (HF) and may allow for the monitoring of therapy in patients with HF over time. One view often taken to simplify their use is that elevated values reflect a more exuberant counterregulatory response to hemodynamic stress,
Jaffe, Allan S.
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The immuneregulator role of neprilysin (NEP) in invertebrates [PDF]
Invertebrate Survival Journal, 2012 Neprilysin (NEP) represents an important enzyme in both vertebrates and invertebrates. In the present report we have focused our attention to invertebrates. In particular, a structure related to CD10/NEP as well as its activity in different tissues, such
A. Grimaldi +3 more
core +5 more sources
Frontiers in Aging Neuroscience, 2021 Alzheimer’s disease (AD) is pathologically characterized by extracellular beta-amyloid (Aβ) plaques and intraneuronal tau tangles in the brain. A therapeutic strategy aims to prevent or clear these Aβ plaques and the Aβ-degrading enzyme neprilysin is a ...
Christian Humpel
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Circulating Neprilysin Level Predicts the Risk of Cardiovascular Events in Hemodialysis Patients
Frontiers in Cardiovascular Medicine, 2021 Background: Neprilysin inhibition has demonstrated impressive benefits in heart failure treatment, and is the current focus of interest in cardiovascular (CV) and kidney diseases.
Hyeon Seok Hwang +9 more
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Effect of Neprilysin Inhibition on Alzheimer Disease Plasma Biomarkers
JAMA Neurology, 2023 This exploratory analysis of a randomized clinical trial evaluates the effect of neprilysin inhibition on Alzheimer disease blood biomarkers in patients with heart disease.
W. Brum +6 more
semanticscholar +1 more source
Neprilysin inhibitors and risk of Alzheimer's disease: A future perspective
Journal of Cellular and Molecular Medicine, 2023 Alzheimer's disease (AD) is a heterogeneous neurodegenerative disease with multifaceted neuropathological disorders. AD is characterized by intracellular accumulation of phosphorylated tau proteins and extracellular deposition of amyloid beta (Aβ ...
Naif H. Ali +8 more
semanticscholar +1 more source
Neprilysin Inhibition in the Prevention of Anthracycline-Induced Cardiotoxicity
Cancers, 2023 Simple Summary Anthracycline-induced cardiotoxicity (AIC) poses a significant clinical challenge in the management of cancer patients. Thus, the development of effective preventive measures for AIC is a heavily studied subject in the field of cardio ...
Aleksandra Sobiborowicz-Sadowska +2 more
semanticscholar +1 more source
Soluble neprilysin and survival in critically ill patients
ESC Heart Failure, 2022 Background Critically ill patients admitted to an intensive care unit (ICU) exhibit a high mortality rate irrespective of the initial cause of hospitalization.
Max Lenz +10 more
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Plasma Neprilysin Displays No Relevant Association With Neurohumoral Activation in Chronic HFrEF
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background Neprilysin is a transmembrane endopeptidase involved in the breakdown of a variety of vasoactive peptides and serves as a therapeutic target in heart failure with reduced ejection fraction (HFrEF).
Suriya Prausmüller +8 more
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