Neprilysin inhibition in chronic kidney disease [PDF]
Nephrology Dialysis Transplantation, 2014 Despite current practice, patients with chronic kidney disease (CKD) are at increased risk of progression to end-stage renal disease and cardiovascular events. Neprilysin inhibition (NEPi) is a new therapeutic strategy with potential to improve outcomes for patients with CKD.
Judge, P +3 more
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Neprilysin Deficiency Protects Against Fat-Induced Insulin Secretory Dysfunction by Maintaining Calcium Influx [PDF]
, 2014 Neprilysin contributes to free fatty acid (FFA)-induced cellular dysfunction in nonislet tissues in type 2 diabetes. Here, we show for the first time that with prolonged FFA exposure, islet neprilysin is upregulated and this is associated with reduced ...
Andrikopoulos, Sofianos +5 more
core +1 more source
Autocrine regulation of human sperm motility by tachykinins
Reproductive Biology and Endocrinology, 2010 Background We examined the presence and function of tachykinins and the tachykinin-degrading enzymes neprilysin (NEP) and neprilysin-2 (NEP2) in human spermatozoa.
Pinto Francisco M +7 more
doaj +1 more source
Effect of sacubitril/valsartan on recurrent events in the prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure trial (PARADIGM-HF) [PDF]
, 2018 Aims: Recurrent hospitalizations are a major part of the disease burden in heart failure (HF), but conventional analyses consider only the first event. We compared the effect of sacubitril/valsartan vs.
Abraham +18 more
core +3 more sources
JACC: Heart Failure, 2015 Neprilysin (NEP) is a membrane-bound enzyme with a large extracellular component that hydrolyzes atrial natriuretic peptide (ANP), but less so brain natriuretic peptide (BNP), and degrades various very important endogenous vasoactive peptides, including adrenomedullin and bradykinin for ...
Alexandre Mebazaa, Marie-France Seronde
openaire +3 more sources
Serum neprilysin levels are elevated in preeclampsia
Taiwanese Journal of Obstetrics and Gynecology, 2021 To evaluate the possible associations between serum Neprilysin (NEP) levels and preeclampsia and mild and severe preeclampsia subgroups.Fifty-five consecutive women with mild preeclampsia and fifty-five consecutive women with severe preeclampsia were compared with 110 approximately gestational age-matched (±1 week) women with an uncomplicated pregnancy.
Tüten, Nevin +8 more
openaire +6 more sources
Dynamic Changes in Pentraxin-3 and Neprilysin in ST Segment Elevation Myocardial Infarction
Biomedicines, 2022 Pentraxin-3 (PTX3) and neprilysin have been associated with increased morbidity and mortality in chronic inflammatory disease and heart failure, but these biomarkers have been studied less in patients with ST segment elevation myocardial infarction ...
Rahel Befekadu +4 more
doaj +1 more source
Impacts of the combined exposure to seawater acidification and arsenic on the proteome of Crassostrea angulata and Crassostrea gigas [PDF]
, 2018 Proteomic analysis was performed to compare the effects of Arsenic (As), seawater acidification (Low pH) and the combination of both stressors (Low pH + As) on Crassostrea angulata and Crassostrea gigas juveniles in the context of global environmental ...
Bebianno, Maria +6 more
core +1 more source
INNOVATIVE STRATEGY IN THERAPY OF CARDIAC INSUFFICIENCY
Медицинский совет, 2017 The article is devoted to the innovative drug to treat chronic cardiac insufficiency – a combination of sakubitril neprilysin inhibitor and first type angiotension II receptor antagonist valsartan (sacubitril/valsartan).
N. A. Jaiani
doaj +1 more source
Potential of valsartan+sacubitril therapy in hypertensive heart disease
Российский кардиологический журнал, 2021 The course of hypertension is often complicated by left ventricular hypertrophy (or hypertensive heart disease, HHD). The main “corridor” of natural HHD is development of heart failure with preserved ejection fraction (HFpEF).
A. G. Ovchinnikov +4 more
doaj +1 more source