Results 31 to 40 of about 16,895 (259)

Circulating neprilysin clears brain amyloid [PDF]

Molecular and Cellular Neuroscience, 2010
The use of the peptidase neprilysin (NEP) as a therapeutic for lowering brain amyloid burden is receiving increasing attention. We have previously demonstrated that peripheral expression of NEP on the surface of hindlimb muscle lowers brain amyloid burden in a transgenic mouse model of Alzheimer's disease.
Yinxing, Liu, Christa, Studzinski, Tina, Beckett, M Paul, Murphy, Ronald L, Klein, Louis B, Hersh   +5 more
openaire   +2 more sources

Blockade of the Neprilysin and Angiotensin Ameliorates Oxidative Stress in the Cardiovascular Target Tissues of Dexamethasone-induced Hypertensive Rats

Haseki Tıp Bülteni, 2020
Aim:The imbalance between production of reactive oxygen species and antioxidant defense determines the degree of oxidative toxicity and severity of subsequent myocardial damage.We aimed to evaluate the anti-oxidative effects of neprilysin and angiotensin
Duygun Altıntaş Aykan, Muhammed Seyithanoğlu, Nadire Eser, Burak Tanrıverdi, Yaman Selma   +4 more
doaj   +1 more source

Expression of Neprilysin in Skeletal Muscle by Ultrasound-Mediated Gene Transfer (Sonoporation) Reduces Amyloid Burden for AD

Molecular Therapy: Methods & Clinical Development, 2020
Amyloid β (Aβ) accumulation in the brain is considered to be one of the major pathological changes in the progression of Alzheimer’s disease (AD). Neprilysin (NEP) is a zinc metallopeptidase that efficiently degrades Aβ.
Yuanli Li, Yadi Wang, Jue Wang, Ka Yee Chong, Jingjing Xu, Zhaohui Liu, Chunlei Shan   +6 more
doaj   +1 more source

Breakthrough in Heart Failure therapy: LCZ696 combining ACE-Neprilysin inhibition

Asian Journal of Medical Sciences, 2017
Background: Current Heart failure (HF) pharmacotherapy has been unsatisfactory in halting disease progression completely. Aims and Objective: To evaluate the role of LCZ696, a recent FDA-approved ACE -Neprilysin inhibitor (ARNi) in the management of ...
Sandeep Lahiry
doaj   +1 more source

Elabela Protects Spontaneously Hypertensive Rats From Hypertension and Cardiorenal Dysfunctions Exacerbated by Dietary High-Salt Intake

Frontiers in Pharmacology, 2021
Objectives: Arterial hypertension, when exacerbated by excessive dietary salt intake, worsens the morbidity and mortality rates associated with cardiovascular and renal diseases.
Xavier Sainsily, Xavier Sainsily, Xavier Sainsily, David Coquerel, David Coquerel, Hugo Giguère, Hugo Giguère, Lauralyne Dumont, Lauralyne Dumont, Kien Tran, Kien Tran, Christophe Noll, Andrei L. Ionescu, Andrei L. Ionescu, Jérôme Côté, Jérôme Côté, Jean-Michel Longpré, Jean-Michel Longpré, André Carpentier, Éric Marsault, Éric Marsault, Olivier Lesur, Olivier Lesur, Philippe Sarret, Philippe Sarret, Mannix Auger-Messier, Mannix Auger-Messier   +26 more
doaj   +1 more source

INNOVATIVE STRATEGY IN THERAPY OF CARDIAC INSUFFICIENCY

Медицинский совет, 2017
The article is devoted to the innovative drug to treat chronic cardiac insufficiency – a combination of sakubitril neprilysin inhibitor and first type angiotension II receptor antagonist valsartan (sacubitril/valsartan).
N. A. Jaiani
doaj   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Neprilysin inhibition in chronic kidney disease [PDF]

Nephrology Dialysis Transplantation, 2014
Despite current practice, patients with chronic kidney disease (CKD) are at increased risk of progression to end-stage renal disease and cardiovascular events. Neprilysin inhibition (NEPi) is a new therapeutic strategy with potential to improve outcomes for patients with CKD.
Judge, P, Haynes, R, Landray, M, Baigent, C   +3 more
openaire   +2 more sources

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

Ginsenoside F1 Protects the Brain against Amyloid Beta-Induced Toxicity by Regulating IDE and NEP

Life, 2022
Ginsenoside F1, the metabolite of Rg1, is one of the most important constituents of Panax ginseng. Although the effects of ginsenosides on amyloid beta (Aβ) aggregation in the brain are known, the role of ginsenoside F1 remains unclear.
Yee-Jin Yun, Bong-Hwan Park, Jingang Hou, Jung-Pyo Oh, Jin-Hee Han, Sun-Chang Kim   +5 more
doaj   +1 more source