The effect of sacubitril/valsartan compared to olmesartan on cardiovascular remodelling in subjects with essential hypertension: the results of a randomized, double-blind, active-controlled study [PDF]
, 2017 Aims: Progressive aortic stiffening eventually leads to left ventricular (LV) hypertrophy and heart failure if left untreated. Anti-hypertensive agents have been shown to reverse this to some extent. The effects of sacubitril/valsartan (LCZ696), a dual-
Aichner, Solveig +15 more
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IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline [PDF]
, 2016 Alzheimer’s disease (AD) is a devastating condition with no known effective treatment. AD is characterized by memory loss as well as impaired locomotor ability, reasoning, and judgment.
Chan, Ivy C. W. +10 more
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Unwinding the Interaction of Natriuretic Peptides and Neprilysin∗ [PDF]
Journal of the American College of Cardiology, 2015 Natriuretic peptides are an important aid for the diagnosis of heart failure (HF) and may allow for the monitoring of therapy in patients with HF over time. One view often taken to simplify their use is that elevated values reflect a more exuberant counterregulatory response to hemodynamic stress,
Jaffe, Allan S.
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Neprilysin Deficiency Protects Against Fat-Induced Insulin Secretory Dysfunction by Maintaining Calcium Influx [PDF]
, 2014 Neprilysin contributes to free fatty acid (FFA)-induced cellular dysfunction in nonislet tissues in type 2 diabetes. Here, we show for the first time that with prolonged FFA exposure, islet neprilysin is upregulated and this is associated with reduced ...
Andrikopoulos, Sofianos +5 more
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Angiotensin receptor-neprilysin inhibitor for the treatment of heart failure: a review of recent evidence [PDF]
The Korean Journal of Internal Medicine, 2020 Heart failure (HF) is a growing health concern in aging societies worldwide. Sacubitril/valsartan is changing the real-world treatment in the whole spectrum of HF.
Hong-Mi Choi, Mi-Seung Shin
doaj +1 more source
Neprilysin inhibition in chronic kidney disease [PDF]
Nephrology Dialysis Transplantation, 2014 Despite current practice, patients with chronic kidney disease (CKD) are at increased risk of progression to end-stage renal disease and cardiovascular events. Neprilysin inhibition (NEPi) is a new therapeutic strategy with potential to improve outcomes for patients with CKD.
Judge, P +3 more
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Autocrine regulation of human sperm motility by tachykinins
Reproductive Biology and Endocrinology, 2010 Background We examined the presence and function of tachykinins and the tachykinin-degrading enzymes neprilysin (NEP) and neprilysin-2 (NEP2) in human spermatozoa.
Pinto Francisco M +7 more
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Frontiers in Aging Neuroscience, 2022 BackgroundThe incidence of atrial fibrillation (AF)-related stroke increases with aging. Natriuretic peptides (NPs) family, including Corin-B type natriuretic peptide (BNP)-neprilysin (NEP) protein levels increased with age and are risk markers of ...
Xiaozhu Shen +15 more
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Molecular Implications of natriuretic peptides in the protection from hypertension and target organ damage development [PDF]
, 2019 The pathogenesis of hypertension, as a multifactorial trait, is complex. High blood pressure levels, in turn, concur with the development of cardiovascular damage.
Forte, Maurizio +3 more
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JACC: Heart Failure, 2015 Neprilysin (NEP) is a membrane-bound enzyme with a large extracellular component that hydrolyzes atrial natriuretic peptide (ANP), but less so brain natriuretic peptide (BNP), and degrades various very important endogenous vasoactive peptides, including adrenomedullin and bradykinin for ...
Alexandre Mebazaa, Marie-France Seronde
openaire +3 more sources