Results 41 to 50 of about 25,082 (343)

Effects of neprilysin and neprilysin inhibitors on glucose homeostasis: Controversial points and a promising arena

Journal of Diabetes, 2023
AbstractNeprilysin (NEP) is a transmembrane zinc‐dependent metalloproteinase that inactivates various peptide hormones including glucagon‐like peptide 1 (GLP‐1). NEP inhibitors may be effective in the management of type 2 diabetes mellitus (T2DM) by increasing the circulating level of GLP‐1.
Faisal Holil AlAnazi, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb, Athanasios Alexiou, Marios Papadakis, Hanan A. Ogaly, Yousef Abud Alanazi, Hebatallah M. Saad, Gaber El‐Saber Batiha   +8 more
openaire   +2 more sources

Effects of BNP and Sacubitrilat/Valsartan on Atrial Functional Reserve and Arrhythmogenesis in Human Myocardium

Frontiers in Cardiovascular Medicine, 2022
BackgroundAlthough the angiotensin receptor-neprilysin inhibitor (ARNI) sacubitril/valsartan started a new era in heart failure (HF) treatment, less is known about the tissue-level effects of the drug on the atrial myocardial functional reserve and ...
Uwe Primessnig, Uwe Primessnig, Uwe Primessnig, Peter M. Deißler, Peter M. Deißler, Paulina Wakula, Paulina Wakula, Khai Liem Tran, Khai Liem Tran, Felix Hohendanner, Felix Hohendanner, Felix Hohendanner, Dirk von Lewinski, Florian Blaschke, Florian Blaschke, Christoph Knosalla, Christoph Knosalla, Volkmar Falk, Volkmar Falk, Volkmar Falk, Burkert Pieske, Burkert Pieske, Burkert Pieske, Burkert Pieske, Herko Grubitzsch, Herko Grubitzsch, Frank R. Heinzel, Frank R. Heinzel   +27 more
doaj   +1 more source

Serum neprilysin levels are elevated in preeclampsia

Taiwanese Journal of Obstetrics and Gynecology, 2021
To evaluate the possible associations between serum Neprilysin (NEP) levels and preeclampsia and mild and severe preeclampsia subgroups.Fifty-five consecutive women with mild preeclampsia and fifty-five consecutive women with severe preeclampsia were compared with 110 approximately gestational age-matched (±1 week) women with an uncomplicated pregnancy.
Tüten, Nevin, Malik, Eduard, Gök, Koray, Hamzaoğlu, Kübra, Makul, Melike, Öner, Yahya Özgün, Bulut, Huri, Tüten, Abdullah, Güralp, Onur Şahin   +8 more
openaire   +6 more sources

Influence of Sacubitril/Valsartan (LCZ696) on 30-day readmission after heart failure hospitalization [PDF]

, 2016
Background: Patients with heart failure (HF) are at high risk for hospital readmission in the first 30 days following HF hospitalization. Objectives: This study sought to determine if treatment with sacubitril/valsartan (LCZ696) reduces rates ...
Claggett, Brian L., Desai, Akshay S., Lefkowitz, Martin, McMurray, John J.V., Packer, Milton, Rouleau, Jean L., Shi, Victor, Solomon, Scott D., Starling, Randall, Swedberg, Karl, Teerlink, John, Zile, Michael R.   +11 more
core   +2 more sources

Imbalance in Renal Vasoactive Enzymes Induced by Mild Hypoxia: Angiotensin-Converting Enzyme Increases While Neutral Endopeptidase Decreases

Frontiers in Physiology, 2018
Chronic hypoxia has been postulated as one of the mechanisms involved in salt-sensitive hypertension and chronic kidney disease (CKD). Kidneys have a critical role in the regulation of arterial blood pressure through vasoactive systems, such as the renin-
Carlos P. Vio, Carlos P. Vio, Daniela Salas, Carlos Cespedes, Jessica Diaz-Elizondo, Natalia Mendez, Natalia Mendez, Julio Alcayaga, Rodrigo Iturriaga   +8 more
doaj   +1 more source

Effect of sacubitril/valsartan on recurrent events in the prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure trial (PARADIGM-HF) [PDF]

, 2018
Aims: Recurrent hospitalizations are a major part of the disease burden in heart failure (HF), but conventional analyses consider only the first event. We compared the effect of sacubitril/valsartan vs.
Abraham, Andersen, Anker, Anker, Borer, Ghosh, Greenberg, Lin, McMurray, McMurray, Metcalfe, Neaton, Packer, Rogers, Rogers, Rogers, Rogers, Solomon, Wei   +18 more
core   +3 more sources

Breakthrough in Heart Failure therapy: LCZ696 combining ACE-Neprilysin inhibition

Asian Journal of Medical Sciences, 2017
Background: Current Heart failure (HF) pharmacotherapy has been unsatisfactory in halting disease progression completely. Aims and Objective: To evaluate the role of LCZ696, a recent FDA-approved ACE -Neprilysin inhibitor (ARNi) in the management of ...
Sandeep Lahiry
doaj   +1 more source

Tripchlorolide attenuates β-amyloid generation by inducing NEP activity in N2a/APP695 cells

Translational Neuroscience, 2021
Alzheimer’s disease (AD) is a neurodegeneration disease. The previous work from our research group demonstrated the neuroprotective effects of tripchlorolide (T4) in AD animal models.
Zeng Yuqi, Li Yongkun, Shen Hui, Lin Nan, Zhang Jian   +4 more
doaj   +1 more source

Sacubitril/valsartan reduces serum uric acid concentration, an independent predictor of adverse outcomes in PARADIGM-HF [PDF]

, 2017
Aims: Elevated serum uric acid concentration (SUA) has been associated with an increased risk of cardiovascular disease, but this may be due to unmeasured confounders.
Chen, Chen-Huan, Desai, Akshay S., Dukát, Andrej, Jhund, Pardeep S., Kristensen, Søren L., Køber, Lars, Lefkowitz, Martin P., McMurray, John J.V., Mogensen, Ulrik M., Packer, Milton, Prescott, Margaret F., Ramires, Felix, Rouleau, Jean L., Senni, Michele, Shi, Victor C., Solomon, Scott D., Swedberg, Karl   +16 more
core   +3 more sources

Angiotensin receptor blocker neprilysin inhibitors

World Journal of Cardiology, 2021
Heart failure (HF) is a clinical syndrome that results from a structural or functional cardiac disorder that reduces the ability of the ventricle of the heart to fill with, or eject, blood. It is a multifaceted clinical condition that affects up to 2% of the population in the developed world, and is linked to significant morbidity and mortality; it is ...
Suguru Asako, Ippei Osugi, Tomohisa Nomura, Daisuke Usuda, Manabu Sugita, Kenki Usami, Toshihiro Higashikawa, Shintaro Shimozawa, Keiko Mizuno, Takayuki Komatsu, Risa Katou, Toshihiko Yoshizawa, Sakurako Ito, Shungo Tokunaga, Akihiko Kondo, Hiroki Takami, Yuta Hotchi, Jiro Oba, Kentaro Mishima   +18 more
openaire   +3 more sources