Results 51 to 60 of about 25,082 (343)

Efficacy of sacubitril/valsartan relative to a prior decompensation: the PARADIGM-HF trial [PDF]

, 2016
Objectives: This study assessed whether the benefit of sacubtril/valsartan therapy varied with clinical stability. Background: Despite the benefit of sacubitril/valsartan therapy shown in the PARADIGM-HF (Prospective Comparison of ARNI with ...
Claggett, Brian, Desai, Akshay, Lefkowitz, Martin, McMurray, John J.V., Packer, Milton, Rouleau, Jean, Shi, Victor, Solomon, Scott D., Swedberg, Karl, Zile, Michael R.   +9 more
core   +2 more sources

Adipolin, Chemerin, Neprilysin and Metabolic Disorders Associated with Obesity

Applied Sciences, 2023
Adipolin, neprilysin, and chemerin have pleiotropic properties; therefore, their concentrations may influence health complications associated with obesity.
Marcelina Sperling, Teresa Grzelak, Marta Pelczyńska, Paweł Bogdański, Krystyna Czyżewska, Dorota Formanowicz   +5 more
doaj   +1 more source

Present and future pharmacotherapeutic agents in heart failure: an evolving paradigm [PDF]

, 2016
Many conditions culminate in heart failure (HF), a multi-organ systemic syndrome with an intrinsically poor prognosis. Pharmacotherapeutic agents that correct neurohormonal dysregulation and haemodynamic instability have occupied the forefront of ...
Abozguia, AIRE Study Group, Alexander, Alexander, Alexander, Alexander, Ashrafian, Bailey, Bailey, Basu, Beadle, Braunwald, Brown, Burgoyne, Chaitman, Chatterjee, Chung, CIBIS-II Study Group, Cleland, Clerc, Cohn, Cohn, Cohn, CONSENSUS Trial Study Group, Conway, Cook, Dai, Digitalis Investigation Group, Doenst, Dzau, Dzau, Faris, Flather, Follath, Foster, Fox, Fox, Fragasso, Furberg, Gheorghiade, Gladwin, Goffart, Granger, Greenberg, Guazzi, Guazzi, Heymans, Hobbs, Holubarsch, Horowitz, Horowitz, Kantor, Kapil, Kato, Kennedy, Kennedy, Kostis, Larsen, Lee, Lopaschuk, Luiken, Lundberg, Maher, Maier, Mancini, Mann, Mann, Massie, Mccormack, Mcdowell, Mcmurray, Mcmurray, Merit-Hf Study Group, Munzel, Munzel, Neglia, Neubauer, Ormerod, Packer, Packer, Paul, Pawson, Pfeffer, Pfeffer, Pitt, Pitt, Rathore, Rauchhaus, Redfield, Rona, Sack, Sarraf, Schmidt-Schweda, Schrauwen, Schwarz, Shah, Shah, Siddiqi, Singh, SOLVD Investigators, Stanley, Swedberg, Szwed, Taylor, Teerlink, Tilemann, Torre-Amione, Totzeck, Turcani, Unger, Van Der Vusse, Van Faassen, Vardeny, Webb, Yin, Yusuf, Zamani, Zannad, Zannad, Zhang   +119 more
core   +1 more source

INNOVATIVE STRATEGY IN THERAPY OF CARDIAC INSUFFICIENCY

Медицинский совет, 2017
The article is devoted to the innovative drug to treat chronic cardiac insufficiency – a combination of sakubitril neprilysin inhibitor and first type angiotension II receptor antagonist valsartan (sacubitril/valsartan).
N. A. Jaiani
doaj   +1 more source

Blockade of the Neprilysin and Angiotensin Ameliorates Oxidative Stress in the Cardiovascular Target Tissues of Dexamethasone-induced Hypertensive Rats

Haseki Tıp Bülteni, 2020
Aim:The imbalance between production of reactive oxygen species and antioxidant defense determines the degree of oxidative toxicity and severity of subsequent myocardial damage.We aimed to evaluate the anti-oxidative effects of neprilysin and angiotensin
Duygun Altıntaş Aykan, Muhammed Seyithanoğlu, Nadire Eser, Burak Tanrıverdi, Yaman Selma   +4 more
doaj   +1 more source

The Association between Neprilysin gene polymorphisms and Alzheimer’s disease in Tibetan population

Brain and Behavior, 2021
Objectives Alzheimer's disease (AD) is a well‐known neurodegenerative disease, of which the hallmark is the disposition of β‐amyloid (Aβ) in the form of plaque in the brain.
Siwei Chen, Dunzhu Mima, Haiqiang Jin, Qu Dan, Fei Wang, Juan Cai, Lin Shi, Huali Wang, Ailian Du, Ying Tang, Yongan Sun   +10 more
doaj   +1 more source

Preclinical Characterization of a Stabilized Gastrin-Releasing Peptide Receptor Antagonist for Targeted Cancer Theranostics

Biomolecules, 2023
Radiolabeled gastrin-releasing peptide receptor (GRPR) antagonists have shown great promise for the theranostics of prostate cancer; however, their suboptimal metabolic stability leaves room for improvements. It was recently shown that the replacement of
Ayman Abouzayed, Panagiotis Kanellopoulos, Alisa Gorislav, Vladimir Tolmachev, Theodosia Maina, Berthold A. Nock, Anna Orlova   +6 more
doaj   +1 more source

Inhibition of neprilysin with sacubitril without RAS blockage aggravates renal disease in Dahl SS rats

Renal Failure, 2021
Salt-sensitive (SS) hypertension is accompanied with severe cardiorenal complications. In this condition, elevated blood pressure (BP) resulting from salt retention is associated with counterintuitively lower levels of atrial natriuretic peptide (ANP ...
Iuliia Polina, Morgan J. Spicer, Mark Domondon, Ryan S. Schibalski, Elizaveta Sarsenova, Regina F. Sultanova, Daria V. Ilatovskaya   +6 more
doaj   +1 more source

Toward Stability Enhancement of NTS₁R-Targeted Radioligands: Structural Interventions on [^99mTc]Tc-DT1

Pharmaceutics, 2023
The neurotensin subtype 1 receptor (NTS1R) is overexpressed in a number of human tumors, thereby representing a valid target for cancer theranostics with radiolabeled neurotensin (NT) analogs like [99mTc]Tc-DT1 (DT1, N4-Gly7-NT(8-13)). Thus far, the fast
Panagiotis Kanellopoulos, Berthold A. Nock, Eric P. Krenning, Theodosia Maina   +3 more
doaj   +1 more source

Impacts of the combined exposure to seawater acidification and arsenic on the proteome of Crassostrea angulata and Crassostrea gigas [PDF]

, 2018
Proteomic analysis was performed to compare the effects of Arsenic (As), seawater acidification (Low pH) and the combination of both stressors (Low pH + As) on Crassostrea angulata and Crassostrea gigas juveniles in the context of global environmental ...
Bebianno, Maria, Figueira, Etelvina, Freitas, Rosa, Mestre, Nélia, Moreira, Anthony, Schrama, Denise, Soares, Amadeu M.V.M.   +6 more
core   +1 more source