Results 51 to 60 of about 14,163 (275)
Molecular Implications of natriuretic peptides in the protection from hypertension and target organ damage development [PDF]
, 2019 The pathogenesis of hypertension, as a multifactorial trait, is complex. High blood pressure levels, in turn, concur with the development of cardiovascular damage.Forte, Maurizio, Marchitti, Simona, Rubattu, Speranza, Volpe, Massimo +3 morecore +1 more sourceUrinary neprilysin in the critically ill patient [PDF]
BMC Nephrology, 2017 Critically ill patients in intensive care face hazardous conditions. Among these, acute kidney injury (AKI) is frequently seen as a result of sepsis. Early diagnosis of kidney injury is of the utmost importance in the guidance of interventions or avoidance of treatment-induced kidney injury. On these grounds, we searched for markers that could indicate Ludwig Wagner, Karl Mechtler, Sahra Pajenda +2 moreopenaire +3 more sourcesEffect of Neprilysin Inhibition on Left Ventricular Remodeling in Patients With Asymptomatic Left Ventricular Systolic Dysfunction Late After Myocardial Infarction
Circulation, 2021 Supplemental Digital Content is available in the text. Background: Patients with left ventricular (LV) systolic dysfunction after myocardial infarction are at a high risk of developing heart failure.K. Docherty, R. Campbell, K. Brooksbank, J. Dreisbach, P. Forsyth, R. Godeseth, T. Hopkins, A. Jackson, Matthew M. Y. Lee, A. McConnachie, G. Roditi, I. Squire, B. Stanley, P. Welsh, P. Jhund, M. Petrie, J. McMurray +16 moresemanticscholar +1 more sourceBLITZ‐HF: a nationwide initiative to evaluate and improve adherence to acute and chronic heart failure guidelines
European Journal of Heart Failure, Volume 24, Issue 11, Page 2078-2089, November 2022., 2022 Aims
To assess adherence to guideline recommendations among a large network of Italian cardiology sites in the management of acute and chronic heart failure (HF) and to evaluate if an ad‐hoc educational intervention can improve their performance on several pharmacological and non‐pharmacological indicators.Michele Massimo Gulizia, Francesco Orso, Andrea Mortara, Donata Lucci, Nadia Aspromonte, Leonardo De Luca, Giuseppe Di Tano, Giuseppe Leonardi, Alessandro Navazio, Giovanni Pulignano, Furio Colivicchi, Andrea Di Lenarda, Fabrizio Oliva, on behalf of
BLITZ‐HF Investigators, G. Pajes, A.R. Felici, P. Midi, G. Leonardi, G. Montana, V. Randazzo, E. Guerri, E. Lo Jacono, V. Zanasi, C. Leuzzi, V. Rizzello, A. Battagliese, N. Pagnoni, G. Pulignano, M. Uguccioni, M.D. Tinti, G.M. Frigo, M. Anselmi, E. Zorzi, I. Battistoni, G.P. Perna, L. Prosseda, M. Pulcini, C. Pellizzari, C. Paolini, G. Bardelli, R. Panciarola, B. Bordoni, S. Urbinati, C. Pedone, C. Greco, E.R. Cosentino, C. Borghi, C. Cuccia, L. Caprini, C. Mariani, C. Borghi, E. Benvenuto, M.B. Zisa, G.M. Francese, M.M. Gulizia, M. Bartolotti, M. Marconi, D. Severini, K. Mboumi, E. Capati, F. Venturi, E. Savini, D. Gabrielli, A. Herbst, F. Orso, F. Sani, C. Minneci, E. Gardini, D. Nanni, C. Lirato, F. Piemonte, P. Ameri, M. Canepa, F. Mainardi, R. Ghinazzi, F. Poletti, C. Inserra, S. Arcidiacono, V. Crisci, C.C. De Carlini, S. Maggiolini, F. Napoli, A.G. Versace, I. Di Matteo, A. Sacco, A.F. Giglio, M.G. Cipriani, G. Mombelli, A. Alberti, V. Antonazzo, O. Agostoni, G. Riboni, G. Guazzotti, S. Mazzetti, A. Mortara, L. Montagna, M.G. Perrelli, L. Scelsi, S. Ghio, A. Gualco, C. Opasich, L. Filippucci, A. Burini, I. Puggia, E. Loiudice, G. Iabichella, A. Nicosia, A. Frisinghelli, G. De Angelis, P. Del Corso, F. Marzo, S. Carigi, G. Piovaccari, S. Refice, T. Nejat, S.A. Di Fusco, F. Colivicchi, D. Pini, P. Romano, G. Padula, A. Gigantino, L. Spera, A. Pagliaro, L.L. Piccioni, C. Napoletano, C. Calcagnile, P. Sbarra, D. Belloli, P.C. Sganzerla, M. Merlo, V. De Paris, M. Driussi, D. Miani, C.A. Gianonatti, L. Moretti, G. Licciardello, V. Palmieri, P. Costa, S. Zingaro, L. Tedesco, A. Iacovoni, M. Liotino, A. Ravera, A. De Castro, G. Rossetti, M. Corda, D. Armata, G. Vianello, E. Pelissero, G. Ruberti, S. D'Orazio, C. Pedrinazzi, D. Robba, A. Carbone, F. De Cian, A. Fucili, F. Grossi, N.D. Brunetti, C. Minoia, M. Pernigo, S. Costa, L. Esposito, G. Senatore, P. Pelaggi, R. Poddighe, E. Zanelli, L. Salvini, G. Galati, A. Zanocco, M. Cannillo, A. Vincenzi, M.A. Losi, L. Caliendo, V. Orrù, E. Carluccio, L. Garritano, E. Garelli, R. Poletti, M. Taglioli, G. Scopelliti, M. Lo Presti, C. Gardini, S. Iosi, C. Tota, M. Mancone, C. De Matteis, F. Rusconi, M.A. Ammirati, G. Cicia, S. Meloni, F. Menozzi, A. Cafro, M. Ribezzo, I. Parrini, S. Giacomelli, G. Russo, F. Morandi, F. Sturniolo +197 morewiley +1 more sourceAnalyzing Corin–BNP–NEP Protein Pathway Revealing Differential Mechanisms in AF-Related Ischemic Stroke and No AF-Related Ischemic Stroke
Frontiers in Aging Neuroscience, 2022 BackgroundThe incidence of atrial fibrillation (AF)-related stroke increases with aging. Natriuretic peptides (NPs) family, including Corin-B type natriuretic peptide (BNP)-neprilysin (NEP) protein levels increased with age and are risk markers of ...Xiaozhu Shen, Xiaozhu Shen, Nan Dong, Nan Dong, Yiwen Xu, Lin Han, Rui Yang, Juan Liao, Xianxian Zhang, Tao Xie, Yugang Wang, Chen Chen, Mengqian Liu, Yi Jiang, Liqiang Yu, Qi Fang +15 moredoaj +1 more sourceNeprilysin Deficiency Protects Against Fat-Induced Insulin Secretory Dysfunction by Maintaining Calcium Influx [PDF]
, 2014 Neprilysin contributes to free fatty acid (FFA)-induced cellular dysfunction in nonislet tissues in type 2 diabetes. Here, we show for the first time that with prolonged FFA exposure, islet neprilysin is upregulated and this is associated with reduced ...Andrikopoulos, Sofianos, Barrow, Breanne M., Kahn, Steven E., Koh, Duk-Su, Lu, Bao, Zraika, Sakeneh +5 morecore +1 more sourceGuideline‐directed medical therapy in patients undergoing transcatheter edge‐to‐edge repair for secondary mitral regurgitation
European Journal of Heart Failure, Volume 24, Issue 11, Page 2152-2161, November 2022., 2022 Triple guideline‐directed medical therapy (GDMT) prescription was associated with a lower 2‐year mortality compared to non‐triple GDMT prescription (A). Such association was observed in patients with concomitant comorbidities (B). CI, confidence interval; CKD, chronic kidney disease; CMP, cardiomyopathy; HR, hazard ratio; MRA, mineralocorticoid ...Satoshi Higuchi, Mathias Orban, Marianna Adamo, Cristina Giannini, Bruno Melica, Nicole Karam, Fabien Praz, Daniel Kalbacher, Benedikt Koell, Lukas Stolz, Daniel Braun, Michael Näbauer, Mirjam Wild, Philipp Doldi, Michael Neuss, Christian Butter, Mohammad Kassar, Tobias Ruf, Aniela Petrescu, Sebastian Ludwig, Roman Pfister, Christos Iliadis, Matthias Unterhuber, Francisco Sampaio, Diogo Ferreira, Holger Thiele, Stephan Baldus, Ralph Stephan von Bardeleben, Steffen Massberg, Stephan Windecker, Philipp Lurz, Anna Sonia Petronio, JoAnn Lindenfeld, William T. Abraham, Marco Metra, Jörg Hausleiter, EuroSMR Investigators +36 morewiley +1 more sourceImbalance in Renal Vasoactive Enzymes Induced by Mild Hypoxia: Angiotensin-Converting Enzyme Increases While Neutral Endopeptidase Decreases
Frontiers in Physiology, 2018 Chronic hypoxia has been postulated as one of the mechanisms involved in salt-sensitive hypertension and chronic kidney disease (CKD). Kidneys have a critical role in the regulation of arterial blood pressure through vasoactive systems, such as the renin-Carlos P. Vio, Carlos P. Vio, Daniela Salas, Carlos Cespedes, Jessica Diaz-Elizondo, Natalia Mendez, Natalia Mendez, Julio Alcayaga, Rodrigo Iturriaga +8 moredoaj +1 more sourceEffects of BNP and Sacubitrilat/Valsartan on Atrial Functional Reserve and Arrhythmogenesis in Human Myocardium
Frontiers in Cardiovascular Medicine, 2022 BackgroundAlthough the angiotensin receptor-neprilysin inhibitor (ARNI) sacubitril/valsartan started a new era in heart failure (HF) treatment, less is known about the tissue-level effects of the drug on the atrial myocardial functional reserve and ...Uwe Primessnig, Uwe Primessnig, Uwe Primessnig, Peter M. Deißler, Peter M. Deißler, Paulina Wakula, Paulina Wakula, Khai Liem Tran, Khai Liem Tran, Felix Hohendanner, Felix Hohendanner, Felix Hohendanner, Dirk von Lewinski, Florian Blaschke, Florian Blaschke, Christoph Knosalla, Christoph Knosalla, Volkmar Falk, Volkmar Falk, Volkmar Falk, Burkert Pieske, Burkert Pieske, Burkert Pieske, Burkert Pieske, Herko Grubitzsch, Herko Grubitzsch, Frank R. Heinzel, Frank R. Heinzel +27 moredoaj +1 more source
