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Sixty seconds on . . . nerve agents [PDF]
BMJ, 2018 The recent attack on Russian former double agent Sergei Skripal and his daughter Yulia with a nerve agent has triggered a meeting of the government’s COBRA emergency committee. A huge clean-up effort by specially trained troops has also been launched to minimise any remaining risk in Salisbury. Back to your biochemistry classes!
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Behavioral toxicity of nerve agents
2009Publisher Summary Behavioral changes in humans are exposed to highly toxic organophosphorus (OP) compounds, called nerve agents. The incidence of behavioral effects is higher in individuals who have been severely exposed to nerve agents, but they may occur in individuals who have received a small exposure and have no or minimal physical signs and ...
Jiri Kassa +3 more
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Perhydrolysis of nerve agent VX
The Journal of Organic Chemistry, 1993The exceedingly toxic nerve agent VX (O-ethyl S-(2-diisopropymino)ethyl methylphosphonothioate) cannot be detoxified by reaction with hydroxide ion but is rapidly detoxified by perhydrolysis (substitution with HO 2 - ) presumably via an intramolecular oxygen transfer which precludes loss of the ethoxy ...
Linda L. Szafraniec +3 more
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Efficacy of Tacrine as a Nerve Agent Pretreatment
Drug and Chemical Toxicology, 1994Tacrine (THA) was evaluated in vitro and in vivo as a pretreatment for nerve agent intoxication. In vitro experiments showed that the primary effect of THA was direct inhibition of purified fetal bovine serum acetylcholinesterase (AChE) with a slight effect on slowing the aging rate of nerve agent-inhibited AChE.
Koplovitz I +6 more
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Resuscitative challenges in nerve agent poisoning
European Journal of Emergency Medicine, 2003The threat of weapons of mass destruction such as nerve agents has become real since last year. The medical community has established protocols for the rapid evacuation and decontamination of affected civilians. However, protocols for resuscitative measures or acute perioperative care in cases of life-saving surgical interventions in toxic-traumatized ...
Avi A. Weinbroum, Ron Ben Abraham
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Organic Phosphorus Compounds—Nerve Agents
Critical Care Clinics, 2005The organic phosphorous compounds (OPC) include both the military grade nerve agents and the organic phosphorous pesticides. The major mechanism of OPC toxicity is through inhibition of acetylcholinesterase in neuronal synapses leading to excess acetylcholine and overstimulation of target organs. Signs and symptoms depend on the affinity of the OPC for
Claudia L. Barthold, Joshua G. Schier
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The acute treatment of nerve agent exposure
Journal of the Neurological Sciences, 2006Nerve agents (NA) are simple and cheap to produce but can produce casualties on a massive scale. They have already been employed by terrorist organizations and rogue states on civilians and armed forces alike. By inhibiting the enzyme acetylcholine esterase, NAs prevent the breakdown of the neurotransmitter acetylcholine.
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Biomarkers of Nerve Agents Exposure
2009Nerve agents (OPC) could be used in terrorist acts. Investigation of longer-lived biomarkers for verification of exposure to toxic compounds is important for diagnosis and prognosis of there intoxications. We study the effects of doses of toxic agent and the times expire after intoxications on the potential biomarkers.
Todor A. Popov +5 more
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After Salisbury Nerve Agents Revisited
Molecular Informatics, 2018AbstractIn March 2018 the term Novichok (Hoвичoκ) became publically known following an attempted murder of a former Russian spy in Salisbury, UK. Novichok is the name of a group of nerve agents secretly produced by Russia in the later stages of the Cold War.
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