Results 101 to 110 of about 4,888,974 (334)

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Hydrophobic Fluorinated Porous Organic Frameworks for Enhanced Adsorption of Nerve Agents

Applied Sciences, 2020
Humidity in the air can significantly limit the adsorption capacity of porous materials used for the removal of chemical warfare agents (CWAs). Therefore, in this work, we prepared a porous organic material (C-1) and its fluoride derivative (C-1-F) via a
Shuyuan Zhou, Weimin Kong, Kunpeng Wang, Hao Han, Derui Yang, Yue Zhao, Hong Zhou, Qinghao Meng, Ye Yuan   +8 more
doaj   +1 more source

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu, Marcus C. Ng, Gavin P. Winston, Sabrina Schaly, Garima Shukla, Lysa Boissé Lomax   +5 more
wiley   +1 more source

Wearable potentiometric tattoo biosensor for on-body detection of G-type nerve agents simulants

Sensors and Actuators B: Chemical, 2018
A new wearable potentiometric tattoo biosensor for real-time on-body monitoring of G-type nerve agents simulant is described. The skin-worn flexible biosensor responds rapidly and selectively to the fluorine-containing organophosphates (OP) nerve agent ...
R. Mishra, A. Barfidokht, A. Karajić, J. Sempionatto, Joshua Wang, Joseph Wang   +5 more
semanticscholar   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

New Heterostilbene and Triazole Oximes as Potential CNS-Active and Cholinesterase-Targeted Therapeutics

Biomolecules
New furan, thiophene, and triazole oximes were synthesized through several-step reaction paths to investigate their potential for the development of central nervous systems (CNS)-active and cholinesterase-targeted therapeutics in organophosphorus ...
Milena Mlakić, Tena Čadež, Goran Šinko, Irena Škorić, Zrinka Kovarik   +4 more
doaj   +1 more source

Analysis of chemical warfare agents by gas chromatography-mass spectrometry: methods for their direct detection and derivatization approaches for the analysis of their degradation products

Reviews in Analytical Chemistry, 2017
Chemical warfare agents (CWAs) are unarguably one of the most feared toxic substances produced by mankind. Their inception in conventional warfare can be traced as far back as the Middle Ages but their full breakthrough as central players in bellic ...
Valdez Carlos A., Leif Roald N., Hok Saphon, Hart Bradley R.   +3 more
doaj   +1 more source

Development of a Prediction Model for Progression Risk in High‐Grade Gliomas Based on Habitat Radiomics and Pathomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu, Yuxi Gong, Weilin Xu, Xingjian Sun, Gefei Jiang, Lei Qiu, Kexin Shi, Mengxing Wu, Yinjiao Fei, Jinling Yuan, Jinyan Luo, Yurong Li, Yuandong Cao, Minhong Pan, Shu Zhou   +14 more
wiley   +1 more source

Antiviral treatment for Bell's palsy (idiopathic facial paralysis) [PDF]

, 2009
BACKGROUND: Antiviral agents against herpes simplex virus are widely used in the treatment of idiopathic facial paralysis (Bell's palsy), but their effectiveness is uncertain. Significant morbidity can be associated with severe cases.
Abiko, Adour, Adour KK Swanson, Ahangar, Allen, Allen, Antunes, Aquino, Axelsson, Bateman, Brandenberg, Chen, Diego, Egger, Engström, Goudakos, Hato, Hato, Hernández, House, Hultcranzt, Ibarrondo, Inanli, Katusic, Kawaguchi, May, McCormick, Morgan, Morgenlander, Murakami, Petruzelli, Pietersen, Pietersen, Ramos Macias, Ross, Rowlands, Roy, Salinas, Sipe, Stjernquist-Desatnik, Sugita, Sullivan, Takasu, Theil, Wolf, Yanagihara, Yeo, Zhou   +47 more
core   +3 more sources

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source