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Vacancy-Engineered Nanoceria: Enzyme Mimetic Hotspots for the Degradation of Nerve Agents.
Angewandte Chemie - International Edition, 2016Amit A. Vernekar +2 more
semanticscholar +3 more sources
Neurotoxicity of organophosphate nerve agents
, 2020Organophosphate nerve agents of the G-series (tabun, GA; sarin, GB; cyclosarin, GF, and soman, GD) and V-series (VX, RVX, Novichok, etc.) were developed prior to, during and after World War II.
Ramesh C. Gupta
semanticscholar +1 more source
Availability of Zr-Based MOFs for the degradation of nerve agents in all humidity conditions
Microporous and Mesoporous Materials, 2019Organophosphate-based nerve agents are among the most toxic chemical compounds known to mankind. In this report, we studied the degradation of soman (GD) and VX, two of the major nerve agents, by Zr(OH)4 and Zr-based Metal-Organic Frameworks (MOFs) such ...
S. Ryu +5 more
semanticscholar +1 more source
Chemico-Biological Interactions, 2019
Bispyridinium oximes with one (K865, K866, K867) or two (K868, K869, K870) ortho-positioned chlorine moiety, analogous to previously known K027, K048 and K203 oximes, and potent reactivators of human acetylcholinesterase (AChE) inhibited by nerve agents,
Tamara Zorbaz +4 more
semanticscholar +1 more source
Bispyridinium oximes with one (K865, K866, K867) or two (K868, K869, K870) ortho-positioned chlorine moiety, analogous to previously known K027, K048 and K203 oximes, and potent reactivators of human acetylcholinesterase (AChE) inhibited by nerve agents,
Tamara Zorbaz +4 more
semanticscholar +1 more source
Organic Phosphorus Compounds—Nerve Agents
Critical Care Clinics, 2005The organic phosphorous compounds (OPC) include both the military grade nerve agents and the organic phosphorous pesticides. The major mechanism of OPC toxicity is through inhibition of acetylcholinesterase in neuronal synapses leading to excess acetylcholine and overstimulation of target organs. Signs and symptoms depend on the affinity of the OPC for
Claudia L, Barthold, Joshua G, Schier
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Nerve agent toxicity and treatment
Current Treatment Options in Neurology, 2005The clinical syndrome of nerve agent toxicity varies widely, ranging from the classic cholinergic syndrome to flaccid paralysis and status epilepticus. All nerve agents are capable of producing marked neuropathology. Seizure control is strongly associated with protection against acute lethality and brain pathology.
Christopher P, Holstege +1 more
openaire +2 more sources
Nerve Agents: A Comprehensive Review
Journal of Intensive Care Medicine, 2004Nerve agents are perhaps the most feared of potential agents of chemical attack. The authors review the history, physical characteristics, pharmacology, clinical effects, and treatment of these agents.
Sage W, Wiener, Robert S, Hoffman
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Inhalational exposure to nerve agents
Respiratory Care Clinics, 2004The respiratory system plays a major role in the pathogenesis of nerve agent toxicity. It is the major route of entry and absorption of nerve agent vapor, and respiratory failure is the most common cause of death follow-ing exposure. Respiratory symptoms are mediated by chemical irritation,muscarinic and nicotinic receptor overstimulation, and central ...
Alexander S, Niven, Stuart A, Roop
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Catalytic bioscavengers as countermeasures against organophosphate nerve agents.
Chemico-Biological Interactions, 2018Recent years have seen an increasing number of incidence, in which organophosphate nerve agents (OPNAs) have been used against civilians with devastating outcomes.
M. Goldsmith, Y. Ashani
semanticscholar +1 more source
Colorimetric and fluorescent sensors for detection of nerve agents and organophosphorus pesticides
, 2021Qian Chen +9 more
semanticscholar +1 more source