Results 61 to 70 of about 3,463,667 (406)

Randomized trial comparing the incidence of unintended sciatic nerve block following ultrasound-guided pudendal nerve block with two different volumes of ropivacaine for hemorrhoidectomy: A pilot study

Indian Journal of Pain, 2019
Aim: To compare the incidence of unintended sciatic nerve block following pudendal nerve block in the interligamentous plane with two different volumes of ropivacaine for post hemorrhoidectomy pain.
Krishnagopal Vinod, Pranjali Kurhekar, Krishnakumar Sharanya   +2 more
doaj   +1 more source

Effects of early and late diabetic neuropathy on sciatic nerve block duration and neurotoxicity in Zucker diabetic fatty rats [PDF]

, 2017
Background The neuropathy of type II diabetes mellitus (DM) is increasing in prevalence worldwide. We aimed to test the hypothesis that in a rodent model of type II DM, neuropathy would lead to increased neurotoxicity and block duration after lidocaine ...
Blumenthal, S., Boeckh, R., de Girolami, U., Galley, H. F., Galley, H. F., Gerner, P., Hollmann, M. W., Lirk, P., Picardi, S., Stevens, M. F., ten Hoope, W., van Schaik, I. N., Verhamme, C.   +12 more
core  

Our experience on brachial plexus blockade in upper extremity surgery [PDF]

, 2012
Objective: Peripheral nerve blocks are usually used either alone or along with general anesthesia for postoperative analgesia. We also aimed to present the results and experiences.Materials and methods: This retrospective study was conducted to scan the ...
Adnan Tüfek, Celil Alemdar, Feyzi Çelik, Gönül Ölmez Kavak, Haktan Karaman, Orhan Tokgöz, Taner Çiftçi, Zeynep B.Yıldırım, Ömer Uslukaya   +8 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Usefulness of ultrasonography guided femoral and lateral femoral cutaneous nerve blocks in providing analgesia before giving spinal anaesthesia in patients undergoing surgery for intertrochanteric fracture of femur: A randomized clinical trial

Journal of Anaesthesiology Clinical Pharmacology, 2022
Background and Aims: It is challenging to give the patient position for subarachnoid block (SAB) as intertrochanteric (IT) fracture of the femur produces intolerable pain.
Vishwanath Meti, K Lohit, G Amarappa, T C Balaraju, S Lavanya   +4 more
doaj   +1 more source

Timing control for paired plasticity [PDF]

, 2016
Systems, methods and devices for paired training include timing controls so that training and neural stimulation can be provided simultaneously. Paired trainings may include therapies, rehabilitation and performance enhancement training.
Cauller, Larry, Engineer, Navzer Dara, Kilgard, Michael P., McIntyre, Rodriguez Christa, Rosellini, Will   +4 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Sciatic Nerve Block Combined with Flurbiprofen Inhibits Spinal Cord Inflammation and Improves Postoperative Pain in Rats with Plantar Incision

Journal of Pain Research, 2023
Meihong Li,1 Kaiwen Zhang,1 Ting Li,2 Yuye Chen,1 Hu Zang,1 Yingjie Hu,1 Wenlong Yao1 1Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Department of Anesthesiology,
Li M, Zhang K, Li T, Chen Y, Zang H, Hu Y, Yao W   +6 more
doaj  

Gene therapy targeting SARM1 blocks pathological axon degeneration in mice [PDF]

, 2019
Axonal degeneration (AxD) following nerve injury, chemotherapy, and in several neurological disorders is an active process driven by SARM1, an injury-activated NADase.
DiAntonio, Aaron, Doan, Ryan A, Geisler, Stefanie, Huang, Shay X, Mao, Xianrong, Milbrandt, Jeffrey, Park, Jiwoong, Strickland, Amy, Summers, Daniel W   +8 more
core   +1 more source