Results 61 to 70 of about 207,246 (312)

Achilles hero or heel? A systematic review of popliteal nerve block for achilles repair

Foot & Ankle Surgery: Techniques, Reports & Cases
Achilles tendon rupture is an exceptionally common injury, particularly among athletes. Popliteal nerve block is often performed for pain relief during surgical Achilles repair; however, the evidence basis demonstrating its analgesic effectiveness is ...
Connor T.A. Brenna, MD, Shawn Khan, MD MEng, Faraj W. Abdallah, MD FRCPC, Richard Brull, MD FRCPC   +3 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Willin, an upstream component of the Hippo signaling pathway, orchestrates mammalian peripheral nerve fibroblasts [PDF]

, 2013
Willin/FRMD6 was first identified in the rat sciatic nerve, which is composed of neurons, Schwann cells, and fibroblasts. Willin is an upstream component of the Hippo signaling pathway, which results in the inactivation of the transcriptional coactivator
Tilston-Lünel, A.M., Susan C Barnett, Gunn-Moore Frank J., Tilston-Lunel, Andrew Martin, Moleirinho, S., Jennifer R Higginson, Angus Liselotte, Prystowsky Michael B., Calum Patrick, Liselotte Angus, Andrew M. Tilston-lünel, Michael B. Prystowsky, Patrick, C., Susana Moleirinho, Frank J Gunn-Moore, Moleirinho Susana, Gunn-Moore, Frank J, Gunn-Moore, F.J., Prystowsky, M.B., Moleirinho, Susan, Paul A. Reynolds, Maciej Antkowiak, Susan C. Barnett, Jennifer R. Higginson, Antkowiak Maciej, Barnett Susan C., Paul A Reynolds, Higginson, J.R., Reynolds Paul A., Antkowiak, Maciej, Prystowsky, Michael, Michael B Prystowsky, Barnett, Susan, Antkowiak, M., Reynolds, Paul Andrew, Tilston-Lünel Andrew M., Barnett, S.C., Frank J. Gunn-moore, Angus, Liselotte, Andrew M Tilston-Lünel, Patrick Calum, Patrick, Calum, Higginson Jennifer R., Higginson, JR, Angus, L., Reynolds, P.A.   +45 more
core   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Minimal local anesthetic volume for peripheral nerve block: a new ultrasound-guided, nerve dimension-based method

, 2009
BACKGROUND AND OBJECTIVES: Nerve blocks using local anesthetics are widely used. High volumes are usually injected, which may predispose patients to associated adverse events.
Willimann, P, Curatolo, M, Eichenberger, Urs, Huber, Gudrun, Kettner, Stephan C, Pleiner, Johannes, Marhofer, Peter, Kettner, S C, Pleiner, J, Stöckli, Stefan, Stöckli, S, Kapral, S, Kapral, Stephan, Marhofer, P, Curatolo, Michele, Eichenberger, U, Willimann, Patrick, Huber, G   +17 more
core   +1 more source

The Femoral Nerve Block Setting the Agenda for Nursing Care of Older Patients With hip Fractures—A Qualitative Study

SAGE Open Nursing, 2023
Introduction Hip fractures among older people are common worldwide, and it is often associated with preoperative pain. Due to increased comorbidity and high age, traditional pain relief can be a challenge.
Anna Unneby RN, PhD, Birgitta Olofsson RN, PhD, Britt-Marie Lindgren RN, PhD   +2 more
doaj   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Combined posterior lumbar plexus–sciatic nerve block versus combined femoral–obturator–sciatic nerve block for ACL reconstruction

, 2011
Ayman I TharwatAin Shams University, Cairo, EgyptBackground: We compared the efficacy of combined posterior lumbar plexus–sciatic nerve block with that of combined femoral–obturator–sciatic nerve block as anesthesia for ...
Ayman I Tharwat
core  

The use of local anesthesia and nerve blocks for scrotal and penile surgery: Local anaesthesia for scrotal and penile surgery [PDF]

Serbian Journal of Anesthesia and Intensive Therapy
Local anaesthetics are widely used for penile and genital surgery, with techniques tailored to the specific nerve supply and dermatomal distribution of the genitalia.
Lađević Nikola, Petrović Nataša, Jovičić Jelena, Jovanović Vesna, Lazić Miloš, Dimić Nemanja   +5 more
doaj   +1 more source