Results 81 to 90 of about 436,772 (306)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Paravertebral nerve block versus combined serratus anterior plane and intercostal nerve blocks in thoracoscopic lung segment surgery in elderly: a retrospective study

Journal of Cardiothoracic Surgery
Objective In order to accelerate the rapid recovery of elderly patients undergoing lung surgery, we tend to use multimodal analgesic protocols. A retrospective analytical study was used to analyse postoperative analgesic regimens suitable for older ...
Meng Xia, Runfeng Wang
doaj   +1 more source

The use of local anesthesia and nerve blocks for scrotal and penile surgery: Local anaesthesia for scrotal and penile surgery [PDF]

Serbian Journal of Anesthesia and Intensive Therapy
Local anaesthetics are widely used for penile and genital surgery, with techniques tailored to the specific nerve supply and dermatomal distribution of the genitalia.
Lađević Nikola, Petrović Nataša, Jovičić Jelena, Jovanović Vesna, Lazić Miloš, Dimić Nemanja   +5 more
doaj   +1 more source

Neurotoxicity [PDF]

, 2014
Neurotoxicity refers to the direct or indirect effect of chemicals that disrupt the nervous system of humans or animals. Numerous chemicals can produce neurotoxic diseases in humans, and many more are used as experimental tools to disturb or damage the ...
Brust, Creeley, Feldman, Grandjean, Herken, Panzica, Parent, Pessah, Rice, Román, Spencer, Spencer, Tu, Vinken, Yasui, Zawia   +15 more
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Suprascapular Nerve Block for Hemiplegic Shoulder Pain Post Stroke: Subgroup Analysis of Pain Response [PDF]

, 2015
This is an open access article. Open Access Journals by Jacobs Publishers is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.Background and Aims: Suprascapular nerve block is an effective intervention for hemiplegic ...
Adey-Wakeling, Zoe, Crotty, Maria, Liu, Enwu, Shanahan, Ernst Michael   +3 more
core  

The homuncular jigsaw: investigations of phantom limb and body awareness following brachial plexus block or avulsion [PDF]

, 2019
Many neuropsychological theories agree that the brain maintains a relatively persistent representation of one's own body, as indicated by vivid "phantom" experiences.
Giannini, Anna Maria, Haggard, Patrick, Leemhuis, Erik, Pazzaglia, Mariella   +3 more
core   +2 more sources

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Discovery of anatomic variant of saphenous nerve from human cadaver dissection [PDF]

, 2016
Introduction: Saphenous nerve is the longest and largest pure sensory nerve, supplying the medial side of the thigh, leg and foot. Materials and Methods: In the present case study, during routine cadaveric dissection of the antero-medial part of the ...
Ahmad, U., Cheah, Pike See, Mat Taib, Che Norma, Mohd Moklas, Mohamad Aris, Othman, Fauziah, San, Aye Aye   +5 more
core   +1 more source