Results 41 to 50 of about 86,139 (297)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Sympathetic skin response for early detection of type 2 diabetic peripheral neuropathy and nephropathy

Journal of Diabetes Investigation
Background Diabetic peripheral neuropathy (DPN) and diabetic nephropathy (DN) are common complications of type 2 diabetes mellitus (T2DM). Although nerve conduction studies (NCS) and sympathetic skin response (SSR) can detect DPN, the more sensitive ...
Hongying Liu, Sheng Tan, Zhenyu Ma, Qingchun Gao, Weihong Yang   +4 more
doaj   +1 more source

Ultrasound-Guided Electrodes for Conduction Studies of the Saphenous Nerve.

, 2017
PURPOSE Saphenous nerve conduction studies are difficult, because the nerve is hard to localize and evoked responses are small. Ultrasound imaging may assist in the accurate localization and optimal positioning of surface (SE) and needle electrodes ...
Kai M. Rösler, Sebastian Humpert, Rösler, Kai Michael, Humpert, Sebastian, Maria E. Evangelopoulos, Evangelopoulos, Maria E   +5 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Sural nerve conduction studies using ultrasound-guided needle positioning: Influence of age and recording location. [PDF]

, 2016
INTRODUCTION The aim of this study was to compare orthodromic sural nerve conduction study (NCS) results using ultrasound-guided needle positioning (USNP) to surface electrode recordings.
Scheidegger, Olivier, Kihm, Christina, Rösler, Kai Michael, Kamm, Christian Philipp   +3 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

MOTOR NERVE IMPAIRMENT IN DIABETIC PATIENTS WITH SYMMETRICAL DISTAL SENSORY POLYNEUROPATHY: A SINGLE NERVE FIBER CONDUCTION VELOCITY STUDY

, 2014
Introduction: In this study we investigated the clinical utility of single fiber conduction velocity (SF-CV) testing in the evaluation of motor nerve function in diabetic patients with signs and symptoms of symmetrical distal sensory polyneuropathy (DSP).
ULUÇ, KAYIHAN, TANRIDAĞ, TÜLİN, SÜNTER, GÜLİN   +2 more
core   +2 more sources

Nerve conduction studies during various phases of menstrual cycle

National Journal of Physiology, Pharmacy and Pharmacology, 2017
Background: Menstrual cycle is associated with hormonal fluctuations during various phases. Changes in estrogen levels are associated with swings in mood and cognitive functions.
Surbhi Vashisht, Anuj Chawla, Rajneesh Kumar Joshi   +2 more
doaj   +1 more source

Nerve conduction studies in Charcot-Marie-Tooth disease in a cohort from Turkey

, 2011
Introduction: In the demyelinating form of Charcot-Marie-Tooth disease, median motor conduction velocity (MCV) was noted to be around 20 m/s in peripheral myelin protein 22 (PMP22) duplications, in contrast to higher MCVs in connexin 32 gene (Cx32 ...
Oflazer-Serdaroglu, Piraye, Piraye Oflazer-Serdaroglu, Muruvvet Poyraz, Battaloglu, Esra, Zeliha Matur, Esra Battaloglu, Matur, Zeliha, Poyraz, Muruvvet, Feza Deymeer, Yesim Parman, Parman, Yesim, Deymeer, Feza   +11 more
core   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source