Results 51 to 60 of about 86,139 (297)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Influence of age, height, gender on median and ulnar nerve conduction study

National Journal of Physiology, Pharmacy and Pharmacology, 2018
Background: Nerve conduction studies (NCSs) is a test to measure the electrical activity in the nerve and used to measure nerve function disease progression. Physiological factors such as age, temperature, height, and gender are known to affect the nerve
Senthil Kumari K R, Umamaheswari Kannan, Aruna B Patil   +2 more
doaj   +1 more source

A Case Report of Bilateral Foot Drop in a Young Girl

Journal of Gandhara Medical and Dental Sciences, 2023
Acute unilateral foot drop is a well-known entity, but bilateral foot drop in progressive fashion is rare. In particular, slow-progressing bilateral foot drop occurs with various metabolic causes, as in anorexia nervosa, hypothyroid myopathy, Crohn’s ...
Muhammad Inam, Shah Fahad
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Patterns of facial and blink reflex abnormalities in type 2 diabetes mellitus patients with short disease duration: a clue to subclinical cranial neuropathy

Egyptian Rheumatology and Rehabilitation, 2022
Background Cranial neuropathies occur in 3 to 14% of diabetic patients. Motor conduction study of the facial nerve and blink reflex study are electrophysiologic techniques used to assess the facio-trigeminal pathway in diabetic patients.
Gihan Abd El Fattah Tawfik, Hussein El Moghazy Sultan, Gihan Abd El Lattif Younis, Wafaa Samir El Emairy   +3 more
doaj   +1 more source

Transcutaneous vagus nerve stimulation: retrospective assessment of cardiac safety in a pilot study.

, 2012
Background: Vagus nerve stimulation has been successfully used as a treatment strategy for epilepsy and affective disorders for years. Transcutaneous vagus nerve stimulation (tVNS) is a new non-invasive method to stimulate the vagus nerve, which has been
Berthold Langguth, Michael Landgrebe, Prasser, Sarah Julia, Martin Schecklmann, Michael eLandgrebe, Resch, Markus, Markus eResch, Martin eSchecklmann, Florian eGeisreiter, Goeran eHajak, Landgrebe, Michael, Markus Resch, Hajak, Göran, Langguth, Berthold, Timm B Poeppl, Berthold eLangguth, Sarah Julia Prasser, Schecklmann, Martin, Kreuzer, Peter M., Oliver eHusser, Timm B. Poeppl, Husser, Oliver, Peter M. Kreuzer, Oliver Husser, Geisreiter, Florian, Peter Michael Kreuzer, Goeran Hajak, Poeppl, Timm B., Florian Geisreiter   +28 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Comparison of visual evoked potential changes with the duration of Type 2 diabetes mellitus

National Journal of Physiology, Pharmacy and Pharmacology, 2018
Background: Many studies proved that the visual evoked potential (VEP) nerve conduction studies in the diabetes mellitus (DM) patients helped to detect the early changes in nerve conduction.
Sudha D, Chandraselvi E, Saikumar P
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Normative values and factors affecting saphenous nerve responses in a south Asian population: a cross-sectional neurophysiological study at a tertiary care hospital in Pakistan

BMC Neurology
Background The saphenous nerve, a sensory branch of the femoral nerve, is not commonly included in routine lower extremity nerve conduction studies due to a high frequency of non-recordable responses in healthy subjects.
Sajid Hameed, Bisma Aziz, Pinin Baig, Marib Ghulam Rasool Malik, Safia Awan, Sara Khan   +5 more
doaj   +1 more source