Results 61 to 70 of about 12,921,549 (290)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Cervical radiculopathy for neurologists: the role of electrodiagnosis

Arquivos de Neuro-Psiquiatria
Cervical radiculopathy (CR) is a common condition encountered in the general population, usually related to a musculoskeletal degenerative condition.
Lucas Immich Gonçalves, Pedro Helder de Oliveira Junior, José Pedro Soares Baima   +2 more
doaj   +1 more source

Afterdischarges following M waves in patients with voltage-gated potassium channels antibodies

Clinical Neurophysiology Practice, 2017
Objective: To explore the correlation between afterdischarges in motor nerve conduction studies and clinical motor hyperexcitability in patients with voltage-gated potassium channels (VGKC) antibodies. Methods: Six patients with positive serum antibodies
Jingwen Niu, Hongzhi Guan, Liying Cui, Yuzhou Guan, Mingsheng Liu   +4 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Bilateral thoracic outlet syndrome: An uncommon presentation of a rare condition in children

Annals of Indian Academy of Neurology, 2012
We report an adolescent girl who had left-sided neurogenic thoracic outlet syndrome (TOS) due to impingement of the scalenus anterior muscle with bilateral changes on nerve conduction studies and responded well to surgical decompression.
Arif Khan, Rohini R Rattihalli, Nahin Hussain, Arani Sridhar   +3 more
doaj   +1 more source

Nerve Conduction Studies in Patients with Lumbosacral Radiculopathy Caused by Lumbar Intervertebral Disc Herniation

Advances in Orthopedics, 2020
Background. Nerve conduction studies (NCS) are electrodiagnostic tests used to evaluate peripheral nerves functions and aid in the assessment of patients with neuromuscular complaints.
Safa Yousif, Ammar Ahmed, Ahmed Abdelhai, Afraa Musa   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

MOTOR NERVE IMPAIRMENT IN DIABETIC PATIENTS WITH SYMMETRICAL DISTAL SENSORY POLYNEUROPATHY: A SINGLE NERVE FIBER CONDUCTION VELOCITY STUDY

, 2014
Introduction: In this study we investigated the clinical utility of single fiber conduction velocity (SF-CV) testing in the evaluation of motor nerve function in diabetic patients with signs and symptoms of symmetrical distal sensory polyneuropathy (DSP).
ULUÇ, KAYIHAN, TANRIDAĞ, TÜLİN, SÜNTER, GÜLİN   +2 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Sural nerve conduction studies using ultrasound-guided needle positioning: Influence of age and recording location. [PDF]

, 2016
INTRODUCTION The aim of this study was to compare orthodromic sural nerve conduction study (NCS) results using ultrasound-guided needle positioning (USNP) to surface electrode recordings.
Scheidegger, Olivier, Kihm, Christina, Rösler, Kai Michael, Kamm, Christian Philipp   +3 more
core   +2 more sources