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Nerve Crush Injuries—A Model for Axonotmesis

Experimental Neurology, 1994
Nerve crush is a commonly used experimental model in the rat; however, a standard method of inducing this injury has not been defined. This study examined six crush techniques that are frequently used and characterized the subsequent nerve injury. Five types of nerve crush using a No.
P M, Bridge   +6 more
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Alterations in conduction characteristics of crushed peripheral nerves

Restorative Neurology and Neuroscience, 2005
Purpose: Nerve crush injury results in the incapability to maintain conduction of an impulse. Disruption in the myelin sheath causes very important changes in the activities of ion channels. Therefore, crushed and intact sciatic nerves were researched with both histological and electrophysiological methods in this study.
Mert T., Gunay I., Polat S.
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Standardizing Nerve Crushes with a Non-Serrated Clamp

Journal of Reconstructive Microsurgery, 2001
Standardized experimental nerve crush attempts should include the number, duration, and intensity (amount of pressure) of crushes. The authors have developed a new crushing device, a clamp with which predetermined forces can be applied to nerves. This allows the exertion of different, standardized forces to crush a nerve within a scale that produces ...
Beer GM, Steurer J, Meyer VE
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Electrical field effects on crushed nerve regeneration

Experimental Neurology, 1992
The delivery of an electrical field to a transected nerve has been shown to enhance the regeneration. This study examined the effects of such fields on the regeneration of crushed rat sciatic nerve during the first postoperative month. The treated (T) nerve group received a battery implant delivering 10 microA with the cathode at the distal stump.
J M, Kerns, C, Lucchinetti
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Acceleration of the regeneration of the crushed hypoglossal nerve by testosterone

Experimental Neurology, 1983
The effect of testosterone propionate (TP) on regeneration of the crushed hypoglossal nerve was studied in young adult rats. The TP treatment promoted axonal outgrowth as measured by an increase in the proportion of hypoglossal neurons labeled by retrograde transport of horseradish peroxidase injected into the tongue at selected postlesion periods ...
W H, Yu, M C, Yu
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Standardizing optic nerve crushes with an aneurysm clip

Neurological Research, 2010
Despite the widespread use of optic nerve injury models to simulate central nervous system injury, model protocols vary from laboratory to laboratory, making it difficult to directly compare findings between studies.To standardize the optic nerve crush injury model, the commercially available Yasargil aneurysm clip, which provides a consistent clamping
Dong-Fu, Feng   +4 more
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Functional effects of lymphotoxin on crushed peripheral nerve

Microsurgery, 1996
The effect of lymphotoxin (LT) on the functional recovery of crushed peripheral nerves was studied. Using a specially designed compression device, a 5 mm segment of the right sciatic nerve of rats was subjected to a 100 g crush load with a 2 hr duration. The rats in the experimental and control groups received two doses of LT (20 micrograms/kg each) or
J, Algora   +4 more
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Optic nerve crush: protection and regeneration

Brain Research Bulletin, 2004
In neurodegenerative disorders, as well as in acute central nervous system (CNS) injuries, the initial impairment triggers a cascade of destructive events, collectively termed secondary degeneration, which eventually cause much more extensive damage.
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Outcomes of ulnar nerve decompression for double crush syndrome

British Journal of Neurosurgery, 2021
Double crush syndrome (DCS) of the ulnar nerve, including cubital tunnel syndrome with ulnar tunnel syndrome (UTS), is uncommon. This study compares the postoperative outcomes of patients with isolated ulnar tunnel syndrome versus those with double crush syndrome of the elbow and ulnar tunnel.This study enrolled 22 patients: 12 underwent cubital tunnel
Hai-Jiang, Ren   +5 more
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Maturation of axonal sprouts after nerve crush

Experimental Neurology, 1979
Abstract We traced the gradual increase in conduction velocity of axons regenerating after nerve crush injury. Electrophysiologic recordings were made from populations of single myelinated lumbar dorsal root fibers in adult rats at various times after the sciatic nerve had been crushed. Conduction velocity was established for the parent fiber as well
M, Devor, R, Govrin-Lippmann
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