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Gerontology, 2003
<i>Background:</i> Nerve growth factor (NGF), discovered because of its action on cells in the peripheral and the central nervous system, is now known to act also on immune cells in developing and adult subjects. Whether peripheral lymphocytes of aged subjects are responsive to this molecule is less clear.
Antonelli A, Bracci Laudiero L, Aloe L
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<i>Background:</i> Nerve growth factor (NGF), discovered because of its action on cells in the peripheral and the central nervous system, is now known to act also on immune cells in developing and adult subjects. Whether peripheral lymphocytes of aged subjects are responsive to this molecule is less clear.
Antonelli A, Bracci Laudiero L, Aloe L
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Nerve Growth Factor Synthesis and Nerve Growth Factor Receptor Expression in Neural Development
1991Publisher Summary This chapter describes nerve growth factor (NGF) in the context of the neurotrophic theory. It also discusses its implications for understanding the molecular basis of neuron–target interactions in the developing nervous system. Since its discovery, NGF has been the prototype of a class of proteins termed “neurotrophic factors” that
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The expression of growth factor receptors during nerve regeneration
Restorative Neurology and Neuroscience, 1990Growth factors and their receptors play a central role in the regulation of normal and injury-induced regenerative cell growth. In this article we review the data on the expression of growth factor receptors for β-nerve growth factor, platelet-derived growth factor and serum transferrin during regeneration following peripheral nerve injury.
Raivich, G. +3 more
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Regulation of the Synthesis of Nerve Growth Factor and Nerve Growth Factor Receptor
1988The importance of Nerve Growth Factor (NGF) for the development and the maintenance of differentiated properties of peripheral sympathetic and neural crest- derived sensory neurons as well as for basal forebrain cholinergic neurons is well established (cf Levi-Montalcini & Angeletti, 1968; Greene & Shooter, 1980; Thoenen & Barde, 1980; Thoenen et al ...
R. Heumann +7 more
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THE RECEPTORS FOR NERVE GROWTH FACTOR AND OTHER NEUROTROPHINS
Annual Review of Biochemistry, 1993OVERVIEW .. . . . . . . . . . .. . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 823 HISTORICAL ASPECTS . . . . . . . .. . . . . . . . . .. . . . . . . . . . .. . . . . . . . 825 MOLECULAR PROPERTIES . . . . . . . . . . . . . . . . ... . . . . .. . . .... . . . 827 Low-Molecular-Weight Receptor (LNGFR; p75) . l.:' . • . . . . . . . . . .
S, Raffioni, R A, Bradshaw, S E, Buxser
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Nerve Growth Factor Receptor Immunoreactivity in Breast Cancer Patients
Cancer Investigation, 2001Nerve growth factor receptor (NGF-R) has been shown to have antiproliferative, differentiative, or apoptotic effects on some types of tumor cells, whereas in others it may have mitogenic activity. The immunohistochemical distribution of NGF-R was analyzed in a series of tissue samples from breast cancer patients and its relationship with other clinical
ARAGONA, Marcello +7 more
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Nerve Growth Factor Receptors and Signaling in Breast Cancer
Current Cancer Drug Targets, 2004Nerve growth factor (NGF) has long been known for its effects on neuronal cell survival and differentiation. This prototypical neurotrophic factor stimulates neurons through two distinct classes of membrane receptors: the TrkA tyrosine kinase receptor, and the tumor necrosis factor receptor family member p75NTR, also known as the common neurotrophin ...
Dollé, Laurent +5 more
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Effect of retinoic acid on nerve growth factor receptors
Cell and Tissue Research, 1987Retinoic acid (RA), a naturally occurring metabolite of vitamin A, increased the number of receptors for nerve growth factor (NGF) in cultured human neuroblastoma cells (LA-N-1), as indicated by an immunofluorescence assay of cell surface receptors and by specific binding of 125I-NGF to solubilized receptors. Analysis of 125I-NGF binding showed that RA
B E, Haskell +3 more
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Nerve growth factor receptors in the central nervous system
Experimental Neurology, 1988Nerve growth factor (NGF) is well known to be involved in the development, survival, and maintenance of sympathetic and neural crest-derived sensory neurons in the peripheral nervous system. Over the last 10-15 years, however, the role of NGF as a necessary trophic substrate for magnocellular cholinergic neurons in the central nervous system (CNS) has ...
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Nerve Growth Factor (NGF) Receptors in Male Reproductive Organs
1997In addition to its essential role for the survival, development and differentiation of neurons of the central and peripheral nervous systems, nerve growth factor (NGF) seems to exert also a variety of nonneurotrophic activities. In particular, there is considerable evidence for crucial functions of NGF within the male reproductive system.
D, Müller +3 more
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