Results 71 to 80 of about 286,784 (355)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Effect of estrogen on growth and development of nerve cell in cerebellum of rat

浙江大学学报. 农业与生命科学版, 2008
In order to study the effect of estrogen on the development and neurocrine of nerve cell culture vitro of cerebellum, select the nerve cell of cerebellum of one day rat, then observe the growth and development of nerve cell after treatment with 17β ...
CHEN Zheng-li, LUO Qi-hui, FAN Guang-li
doaj   +1 more source

The Effect of Resistance Training Along with Royal Jelly Supplementation on Expression of Nerve Growth Factor and Tyrosine Kinase A Receptor in the Hippocampal Tissue of Alzheimer's Rats [PDF]

, 2022
Amin Ashofteh, Sadegh Cheragh-Birjandi, Hossein TaheriChadorneshin, دانشگاه آزاد اسلامی، بجنورد, Hossein TaheriChadorneshin, دانشگاه بجنورد، بجنورد   +5 more
openalex   +1 more source

Modulation of neurotrophic signaling pathways by polyphenols [PDF]

, 2015
Polyphenols are an important class of phytochemicals, and several lines of evidence have demonstrated their beneficial effects in the context of a number of pathologies including neurodegenerative disorders such as Alzheimer's and Parkinson's disease. In
Firuzi, Omidreza, Hosseini, Razieh, Moosavi, Fatemeh, Saso, Luciano   +3 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Cutaneous lesions sensory impairment recovery and nerve regeneration in leprosy patients

Memorias do Instituto Oswaldo Cruz, 2012
It is important to understand the mechanisms that enable peripheral neurons to regenerate after nerve injury in order to identify methods of improving this regeneration.
Ximena Illarramendi, Emanuel Rangel, Alice Machado Miranda, Ana Claudia Ribeiro de Castro, Giselle de Oliveira Magalhães, Sérgio Luiz Gomes Antunes   +5 more
doaj   +1 more source

Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271. [PDF]

, 2010
The question of whether tumorigenic cancer stem cells exist in human melanomas has arisen in the last few years. Here we show that in melanomas, tumour stem cells (MTSCs, for melanoma tumour stem cells) can be isolated prospectively as a highly enriched ...
A Baroffio, Alexander D. Boiko, Benzion Joshua, C La Porta, C Scheibenbogen, CA O’Brien, CH Jamieson, CJ Eaves, D Marchetti, Daphne P. Ly, Denise L. Johnson, E Passegué, E Quintana, F Truzzi, G Pietra, George P. Yang, I Weissman, Irving L. Weissman, JN Cormier, K Akashi, KS Chan, M Al-Hajj, M Hérin, M Shackleton, Matt van de Rijn, ME Prince, Michael J. Kaplan, Michael T. Longaker, Olga V. Razorenova, OO Akala, P Dalerba, P van der Bruggen, Paris D. Butler, PG Chesa, S Iwamoto, SA Rosenberg, SJ Morrison, SK Singh, Susan M. Swetter, T Miyamoto, T Reya, T Schatton   +41 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Effect of Synthetic Cell-Penetrating Peptides on TrkA Activity in PC12 Cells

Journal of Pharmacological Sciences, 2008
As TrkA, a high-affinity receptor of nerve growth factor (NGF), is a potential target for relieving uncontrolled inflammatory pain, an effective inhibitor of TrkA has been required for pain management.
Munetaka Hirose, Mayumi Takatori, Yoshihiro Kuroda, Mineo Abe, Eri Murata, Tetsuro Isada, Koyo Ueda, Kenji Shigemi, Masayuki Shibazaki, Fumihiro Shimizu, Masashi Hirata, Keita Fukazawa, Masahiro Sakaguchi, Kyoko Kageyama, Yoshifumi Tanaka   +14 more
doaj   +1 more source

Binding of Nerve Growth Factor Receptor in Sympathetic Ganglia [PDF]

Proceedings of the National Academy of Sciences, 1973
125 I-Labeled nerve growth factor binds to membrane preparations from superior cervical ganglia of rabbit in a specific fashion indicative of an interaction with the physiological receptor. Of various tissues examined, binding was observed only in the superior cervical ganglia, a presumed target organ of nerve growth factor ...
S P, Banerjee, S H, Snyder, P, Cuatrecasas, L A, Greene   +3 more
openaire   +2 more sources