Results 61 to 70 of about 1,815,614 (364)

Neurotrophins and neuropeptides as inflammatory mediators in case of chronic dermatosis

Vestnik Dermatologii i Venerologii, 2017
This literature review examines the role of neurotrophins and neuropeptides for the development of skin inflammatory reactions in case of chronic inflammatory dermatoses.
A. A. Kubanova, V. A. Smolyannikova, V. V. Chikin, A. E. Karamova   +3 more
doaj   +1 more source

Magnetic Nanoparticles for Neural Engineering [PDF]

Thanh, Nguyen TK (ed.). Clinical applications of magnetic nanoparticles: From Fabrication to Clinical Applications. CRC press, 2018
Magnetic nanoparticles (MNPs) are the foundation of several new strategies for neural repair and neurological therapies. The fact that a remote force can act on MNPs at the cytoplasmic space constitutes the essence of many new neurotherapeutic concepts. MNPs with a predesigned physicochemical characteristic can interact with external magnetic fields to
arxiv   +1 more source

The statistical mechanics of complex signaling networks : nerve growth factor signaling [PDF]

, 2004
It is becoming increasingly appreciated that the signal transduction systems used by eukaryotic cells to achieve a variety of essential responses represent highly complex networks rather than simple linear pathways. While significant effort is being made to experimentally measure the rate constants for individual steps in these signaling networks, many
arxiv   +1 more source

Neuroprotection, Growth Factors and BDNF-TrkB Signalling in Retinal Degeneration

International Journal of Molecular Sciences, 2016
Neurotrophic factors play key roles in the development and survival of neurons. The potent neuroprotective effects of neurotrophic factors, including brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), glial cell-line derived ...
A. Kimura, K. Namekata, Xiaoli Guo, C. Harada, T. Harada   +4 more
semanticscholar   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Identification of adequate vehicles to carry nerve regeneration inducers using tubulisation

BMC Neuroscience, 2012
Background Axonal regeneration depends on many factors, such as the type of injury and repair, age, distance from the cell body and distance of the denervated muscle, loss of surrounding tissue and the type of injured nerve.
do Nascimento-Elias Adriana Helena, Fresnesdas Bruno César, Schiavoni Maria Cristina Lopes, de Almeida Natália Fernanda Gaspar, Santos Ana Paula, de Oliveira Ramos Jean, Junior Wilson Marques, Barreira Amilton Antunes   +7 more
doaj   +1 more source

Ex-Vivo Stimulation of Adipose Stem Cells by Growth Factors and Fibrin-Hydrogel Assisted Delivery Strategies for Treating Nerve Gap-Injuries

Bioengineering, 2020
Peripheral nerve injuries often result in lifelong disabilities despite advanced surgical interventions, indicating the urgent clinical need for effective therapies.
Katharina M. Prautsch, Lucas Degrugillier, Dirk J. Schaefer, Raphael Guzman, Daniel F. Kalbermatten, Srinivas Madduri   +5 more
doaj   +1 more source

Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors

Journal of Cell Biology, 1985
Nerve growth factor (NGF) regulates the microtubule-dependent extension and maintenance of axons by some peripheral neurons. We show here that one effect of NGF is to promote microtubule assembly during neurite outgrowth in PC12 cells.
David, G. Drubin, Stuart C. Feinstein, Eric M. Shooter, W. Marc, Kirschner   +5 more
semanticscholar   +1 more source

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

FEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou, Florence Geiguer, Sébastien Couraud, Claire Bardel, Jean Viallet, Nazim Benzerdjeb, Léa Payen   +14 more
wiley   +1 more source

Roles of neural stem cells in the repair of peripheral nerve injury

Neural Regeneration Research, 2017
Currently, researchers are using neural stem cell transplantation to promote regeneration after peripheral nerve injury, as neural stem cells play an important role in peripheral nerve injury repair.
Chong Wang, Chang-feng Lu, Jiang Peng, Cheng-dong Hu, Yu Wang   +4 more
doaj   +1 more source