Results 81 to 90 of about 1,869,384 (384)
Pharmacologically targeting Schwann cells to improve regeneration following nerve damage
Frontiers in Cell and Developmental BiologySchwann cells provide essential support for nerve growth and survival following peripheral nerve damage by producing various growth factors and other signalling molecules.
Alaa A. Alhamdi +7 more
doaj +1 more source
Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies
FEBS Open Bio, EarlyView.Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa +13 more
wiley +1 more source
Peripheral Nerve Regeneration and Muscle Reinnervation
International Journal of Molecular Sciences, 2020 Injured peripheral nerves but not central nerves have the capacity to regenerate and reinnervate their target organs. After the two most severe peripheral nerve injuries of six types, crush and transection injuries, nerve fibers distal to the injury site
T. Gordon
semanticscholar +1 more source
The Nerve Growth Factor Signaling and Its Potential as Therapeutic Target for Glaucoma
BioMed Research International, 2014 Neuroprotective therapies which focus on factors leading to retinal ganglion cells (RGCs) degeneration have been drawing more and more attention. The beneficial effects of nerve growth factor (NGF) on the glaucoma have been recently suggested, but its ...
Haitao Wang +6 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić +3 more
wiley +1 more source
Leukemia Inhibitory Factor Augments Neurotrophin Expression and Corticospinal Axon Growth after Adult CNS Injury [PDF]
, 1999 The cytokine leukemia inhibitory factor (LIF) modulates glial and neuronal function in development and after peripheral nerve injury, but little is known regarding its role in the injured adult CNS.
Blesch, A. +5 more
core +1 more source
Brazilian Journal of Otorhinolaryngology, 2023 Objective: To analyze the morphofunctional regeneration process of facial nerve injury in the presence of insulin-like growth factor-1 and mesenchymal stem cells.
Aracele Gonçalves Vieira +7 more
doaj
Exenatide promotes regeneration of injured rat sciatic nerve
Neural Regeneration Research, 2017 Damage to peripheral nerves results in partial or complete dysfunction. After peripheral nerve injuries, a full functional recovery usually cannot be achieved despite the standard surgical repairs. Neurotrophic factors and growth factors stimulate axonal
Ersin Kuyucu +4 more
doaj +1 more source
Two‐way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3
FEBS Open Bio, EarlyView.PAX5::CBFA2T3 (PAX5‐C) is a fusion protein of the B‐cell transcription factor, PAX5, and is found in B‐cell ALL. We propose a putative model of two‐way inhibition of PAX5 transcriptional activity by PAX5‐C. There are two ways of repression by PAX5‐C: DNA‐binding‐dependent way and HDAC‐dependent way, with either being sufficient for the repression. HDAC
Reina Ueno +12 more
wiley +1 more source
International Journal of Molecular Medicine, 2016 Concentrated growth factor (CGF) is a newly generated complex that comprises a fibrin matrix incorporating growth factors and plasmatic and leukocyte cytokines. It has been widely used in bone regenerative medicine.
Jie Qin +6 more
semanticscholar +1 more source