Results 81 to 90 of about 3,055,547 (410)

A novel inhibitor of p75-neurotrophin receptor improves functional outcomes in two models of traumatic brain injury. [PDF]

, 2016
The p75 neurotrophin receptor is important in multiple physiological actions including neuronal survival and neurite outgrowth during development, and after central nervous system injury.
Alam, Antoine, Arnone, Michele, Baroni, Marco, Beattie, Michael S, Bono, Françoise, Bresnahan, Jacqueline C, Canolle, Benoit, Castel, Marie-Noelle, Delbary-Gossart, Sandrine, Delesque-Touchard, Nathalie, Ferguson, Adam R, Ferzaz, Badia, Herbert, Jean-Marc, Laboudie, Patricia, Lamarche, Isabelle, Lee, Sangmi, Lin, Amity, Manley, Geoffrey T, Sacramento, Jeffrey, Salegio, Ernesto A, Savi, Pierre   +20 more
core   +1 more source

Research progress on the metabolic transformation of Shenling Baizhu San under the influence of the gut microbiota

Advanced Chinese Medicine, EarlyView.
Abstract The gut microbiota plays a pivotal role in maintaining host metabolic homeostasis and overall physiological functions. Shenling Baizhu San (SLBZS), a time‐honored classical prescription for tonifying Qi, strengthening the spleen, removing dampness, and arresting diarrhea, has shown broad clinical efficacy in digestive disorders.
Jinlan Di, Xiaochun Zhang
wiley   +1 more source

The Effects of Surgical Antiseptics and Time Delays on RNA Isolated From Human and Rodent Peripheral Nerves

Frontiers in Cellular Neuroscience, 2019
Peripheral Nerve Injury (PNI) is common following blunt or penetrating trauma with an estimated prevalence of 2% among the trauma population. The resulting economic and societal impacts are significant.
Matthew Wilcox, Matthew Wilcox, Matthew Wilcox, Tom J. Quick, Tom J. Quick, Tom J. Quick, James B. Phillips, James B. Phillips   +7 more
doaj   +1 more source

Biodegradable materials for bone defect repair

Military Medical Research, 2020
Compared with non-degradable materials, biodegradable biomaterials play an increasingly important role in the repairing of severe bone defects, and have attracted extensive attention from researchers.
Shuai Wei, Jian-Xiong Ma, Lai Xu, Xiao-Song Gu, Xin-Long Ma   +4 more
doaj   +1 more source

Intradiscal injection for the management of low back pain

JOR Spine, 2022
Low back pain (LBP) is a common clinical problem and a major cause of physical disability, imposing a prominent socioeconomic burden. Intervertebral disc degeneration (IDD) has been considered the main cause of LBP.
Fu Zhang, Songjuan Wang, Baoliang Li, Wei Tian, Zhiyu Zhou, Shaoyu Liu   +5 more
doaj   +1 more source

Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain. [PDF]

, 2020
Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant expansion and proliferation of macrophages around injured sensory neurons in dorsal root ganglia (DRG).
Basbaum, Allan I, Braz, Joao M, Guan, Zhonghui, Hamel, Katherine A, Leff, Jacqueline, Liu, Hongju, Morvan, Maelig G, Yu, Stephen, Yu, Xiaobing   +8 more
core   +1 more source

PolyMorphine provides extended analgesic-like effects in mice with spared nerve injury. [PDF]

, 2017
Morphine is a well-characterized and effective analgesic commonly used to provide pain relief to patients suffering from both acute and chronic pain conditions.
Chen, Renxun, Kolber, Benedict, Lax, Neil C, Leep, Sarah R, Uhrich, Kathryn, Yu, Lei   +5 more
core   +1 more source

The Associations Between Chronic Active Lesions and White Matter Disease: A 7 Tesla Imaging Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The relationship between paramagnetic rim lesions (PRLs) and surrounding normally appearing white matter (NAWM) disease, potentially contributory to the associations seen between PRLs and clinical impairment, is underexplored. Objectives To assess whether PRLs correlate with a greater degree of NAWM injury in early MS.
Ellie McCluey, Ahmad A. Toubasi, Jiacheng Wang, Habeeb F. Kazimuddin, Taegan Vinarsky, Caroline Gheen, Carynn Koch, Zachery Rohm, Bryan Hernandez, Margareta A. Clarke, Rachael Cheek, Rozita Khalili, Chaoyang Jin, Victoria Lim, John Kramer, Junzhong Xu, Ipek Oguz, Francesca Bagnato   +17 more
wiley   +1 more source

The Schwann cell-specific G-protein Gαo (Gnao1) is a cell-intrinsic controller contributing to the regulation of myelination in peripheral nerve system

Acta Neuropathologica Communications
Myelin sheath abnormality is the cause of various neurodegenerative diseases (NDDs). G-proteins and their coupled receptors (GPCRs) play the important roles in myelination. Gnao1, encoding the major Gα protein (Gαo) in mammalian nerve system, is required
Jinghui Xu, Qianqian Peng, Jieyi Cai, Jianghong Shangguan, Wenfeng Su, Gang Chen, Hualin Sun, Changlai Zhu, Yun Gu   +8 more
doaj   +1 more source

Skeletal Muscle Atrophy Was Alleviated by Salidroside Through Suppressing Oxidative Stress and Inflammation During Denervation

Frontiers in Pharmacology, 2019
Skeletal muscle atrophy is a common and debilitating condition that lacks an effective therapy. Oxidative stress and inflammation are two main molecular mechanisms involved in muscle atrophy.
Ziwei Huang, Ziwei Huang, Qingqing Fang, Wenjing Ma, Qiuyu Zhang, Jiaying Qiu, Xiaosong Gu, Huilin Yang, Hualin Sun   +8 more
doaj   +1 more source