Results 261 to 270 of about 1,668,775 (361)

Placental-Derived Connective Tissue Matrix Mediates Murine Recurrent Laryngeal Nerve Regeneration. [PDF]

Laryngoscope
Anekal S, Tadikonda A, Sobczak G, Chen LW, Bhatt A, Wesson T, Finnegan PR, Halum S.   +7 more
europepmc   +1 more source

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

ROS-scavenging lipoic acid-modified chitosan hydrogels with rapid photocrosslinked ability accelerates peripheral nerve regeneration. [PDF]

Regen Biomater
Chen X, Gao R, Liang X, Liu K, Wei Z, Wu X, Goto T, Xiong C, Xu F, Dai H.   +9 more
europepmc   +1 more source

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, EarlyView.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

Mature Schwann Cells Derived From Human Induced Pluripotent Stem Cells Promote Peripheral Nerve Regeneration In Vivo. [PDF]

Neurosci Insights
Fujita K, Ikeguchi R, Aoyama T, Noguchi T, Yoshimoto K, Sakamoto D, Iwai T, Miyamoto T, Takeuchi Y, Nagai-Tanima M, Nohara D, Tooi N, Igura K, Kiboku T, Okama R, Ogasawara H, Matsuda S.   +16 more
europepmc   +1 more source

PRMT9 Aggravated Dopaminergic Neurodegeneration in Parkinson's Disease Model by Facilitating the Degradation of DUSP26 and Inducing Mitochondrial Dysfunction

Advanced Science, EarlyView.
In the pathological state of PD induced by MPP+, the upregulated PRMT9 in dopaminergic neurons translocates into mitochondrion and interacts with DUSP26 and catalyzes its arginine methylation, leading to the ubiquitin‐proteasomal degradation of DUSP26 mediated by Trim32.
Tengfei Liu, Xiaomeng Song, Xin Guo, Rui Xiao, Ru Sun, Qiuran Ji, Lu Yu, Yiquan Li, Qingyi Fu, Qidi Xue, Lingjun Kong, Lin Chen, Chengjiang Gao, Huiqing Liu   +13 more
wiley   +1 more source

Rochelle salt-based biodegradable piezoelectric devices for nerve regeneration and intestinal motility monitoring. [PDF]

Nat Commun
Dai F, Cheng H, Qi H, Cai H, Aziz A, Su T, Guan Y, Cui Y, Meng J, Deng H, Wu Q, Jie Y, Chen L, Wang S, Feng T, Li W, You F, Liu S, Yu B, Yang C, Peng J, Sheng X, Li JF, Zhang M, Li Q, Ma C, Tian L, Zhang J, Wang Y, Yin L.   +29 more
europepmc   +1 more source

Micro‐Galvanic Coupling Programs the Therapeutic Zinc Ion Window to Reconfigure Immune Cascades for Pro‐Regenerative Bone Healing

Advanced Science, EarlyView.
This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun, Bo Jia, Jiahui Shi, Shuang Li, Guo Bao, Dong Bian, Kai Chen, Junlong Tan, Xuenan Gu, Yan Guan, Yu Qin, Xinhua Qu, Xiaogang Wang, Yufeng Zheng, Hongtao Yang   +14 more
wiley   +1 more source

Engineering neural recovery: Micro/nano-structured materials for nerve regeneration. [PDF]

Mater Today Bio
Zhang H, Sha J, Cao S, Feng J, Pang X, Xu D, Hu Y, Li M, Zhang C, Wang Y, Wang H, Chai R.   +11 more
europepmc   +1 more source