Results 91 to 100 of about 1,158,334 (373)

Defining the organizational structure of dopamine and muscarninic acetylcholine receptors [PDF]

, 2015
No abstract ...
Alvarez-Curto, Elisa, Caltabiano, Gianluigi Caltabiano, Liste, María José Varela, Marsango, Sara, Milligan, Graeme   +4 more
core   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Endocytosis-associated patterns in nerve regeneration after peripheral nerve injury

Journal of Orthopaedic Translation, 2021
Background: Clearance of myelin debris and remyelination of myelin are necessary steps for peripheral nerve remodeling and regeneration. It has yet to be clarified which genes or proteins are involved in endocytosis or exocytosis in the removal of myelin
Guidong Shi, Dingyu Hao, Lei Zhang, Jia Qin, Guangyuan Tian, Boyuan Ma, Xianhu Zhou   +6 more
doaj  

Diattenuation Imaging reveals different brain tissue properties [PDF]

Scientific Reports 9(1939), 2018
When transmitting polarised light through histological brain sections, different types of diattenuation (polarisation-dependent attenuation of light) can be observed: In some brain regions, the light is minimally attenuated when it is polarised parallel to the nerve fibres (referred to as D+), in others, it is maximally attenuated (referred to as D ...
arxiv   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Tissue Plasminogen Activator–Mediated Fibrinolysis Protects against Axonal Degeneration and Demyelination after Sciatic Nerve Injury

Journal of Cell Biology, 2000
Tissue plasminogen activator (tPA) is a serine protease that converts plasminogen to plasmin and can trigger the degradation of extracellular matrix proteins.
K. Akassoglou, K. Kombrinck, J. Degen, S. Strickland   +3 more
semanticscholar   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

SARS-CoV-2 entry sites are present in all structural elements of the human glossopharyngeal and vagal nerves: Clinical implications

EBioMedicine, 2022
Summary: Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections result in the temporary loss of smell and taste in about one third of confirmed cases.
Lynn Vitale-Cross, Ildiko Szalayova, Aiden Scoggins, Miklos Palkovits, Eva Mezey   +4 more
doaj  

PROSPECTS FOR USING MITOGEN-ACTIVATED PROTEIN KINASES ERK1/2 AND p38 OF NERVE TISSUE PROGENITORS AS PHARMACOLOGICAL TARGETS FOR THE TREATMENT OF NEURODEGENERATION CAUSED BY ALCOHOL [PDF]

, 2020
G. N. Zyuz’kov, L. А. Miroshnichenko, Е. В. Симанина, T. Yu. Polyakova   +3 more
openalex   +2 more sources

Studies on cultured Schwann cells: the induction of myelin synthesis, and the control of their proliferation by a new growth factor [PDF]

, 1981
We have recently described the use of immunological methods to identify and purify rat Schwann cells. In dissociated cultures of neonatal sciatic nerve, all of the cells can be identified by antigenic criteria as either Schwann cells or fibroblasts.
Brockes, J. P., Fryxell, K. J., Lemke, G. E.   +2 more
core