The avian tectobulbar tract: development, explant culture, and effects of antibodies on the pattern of neurite outgrowth [PDF]
, 1990 The tectobulbar tract is the first long-distance projecting fiber pathway to appear during the development of the avian optic tectum (dorsal half of the mesencephalon).
Kröger, Stephan, Schwarz, U.
core +2 more sources
Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte +13 more
wiley +1 more source
A Jones matrix formalism for simulating three-dimensional polarized light imaging of brain tissue [PDF]
, 2015 The neuroimaging technique three-dimensional polarized light imaging (3D-PLI) provides a high-resolution reconstruction of nerve fibres in human post-mortem brains.
Amunts, Katrin +5 more
core +4 more sources
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
Iron role paradox in nerve degeneration and regeneration
Physiological ReportsIron accumulates in the neural tissue during peripheral nerve degeneration. Some studies have already been suggested that iron facilitates Wallerian degeneration (WD) events such as Schwann cell de‐differentiation.
Samira Bolandghamat +1 more
doaj +1 more source
Development of a Novel Tissue Targeted Nerve Growth Factor: Fibronectin Chimeric Protein as a Potential Therapeutic for Peripheral Nerve Regeneration [PDF]
, 2018 This project sought to develop a novel regenerative fusion protein that directly targets nerve-tissue through the addition of a specific nerve-tissue binding domain. Combining select domains of the extracellular matrix protein fibronectin with nerve growth factor, a singular potent regenerative stimulant was developed.
openaire +2 more sources
Nondirected axonal growth on basal lamina from avian embryonic neural retina [PDF]
, 1987 The vitreous surface of the embryonic avian retinal neuroepithelium was isolated by mechanical disruption of the retina mounted between 2 adhesive substrata.
Halfter, W. +2 more
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Cutaneous Phosphorylated Alpha‐Synuclein in Lewy Body Dementia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To determine the test performance of cutaneous phosphorylated alpha‐synuclein (P‐SYN) in dementia with Lewy bodies (DLB), individuals with reduced Montreal Cognitive Assessment (MoCA) and healthy controls. Methods This is the first subgroup analysis of the Synuclein‐One study, a prospective, blinded study evaluating P‐SYN detection ...
Christopher H. Gibbons +31 more
wiley +1 more source
Neural Regeneration Research, 2015 The extracellular matrix (ECM) performs essential functions in the differentiation, maintenance and remodeling of tissues during development and regeneration, and it undergoes dynamic changes during remodeling concomitant to alterations in the cell-ECM interactions.
Éva Korpos, Ferenc Deák, Ibolya Kiss
openaire +3 more sources
Immune or genetic-mediated disruption of CASPR2 causes pain hypersensitivity due to enhanced primary afferent excitability [PDF]
, 2018 Human autoantibodies to contactin-associated protein-like 2 (CASPR2) are often associated with neuropathic pain, and CASPR2 mutations have been linked to autism spectrum disorders, in which sensory dysfunction is increasingly recognized.
Bennett, David L. +39 more
core +2 more sources