Results 151 to 160 of about 1,158,334 (373)

Biomimetic Design of Biocompatible Neural Probes for Deep Brain Signal Monitoring and Stimulation: Super Static Interface for Immune Response‐Enhanced Contact

Advanced Functional Materials, EarlyView.
Ultrathin, flexible neural probes are developed with an innovative, biomimetic design incorporating brain tissue‐compatible materials. The material system employs biomolecule‐based encapsulation agents to mitigate inflammatory responses, as demonstrated through comprehensive in vitro and in vivo studies.
Jeonghwa Jeong, Gyeonghwa Heo, Young Woo Kwon, Seon Yeong Chae, Min Jae Kim, Ki Jun Yu, Hwa Kyoung Shin, Suck Won Hong   +7 more
wiley   +1 more source

Pickering Emulsion for Enhanced Viability of Plant Growth Promoting Bacteria and Combined Delivery of Agrochemicals and Biologics

Advanced Functional Materials, EarlyView.
Cellulosic emulsions as multi‐cargo agriculture formulations. Pickering emulsions stabilized by cellulose acetate particles provide an effective platform for delivering a range of agricultural cargoes, including plant growth‐promoting bacteria and agrochemicals.
Mariam Sohail, John Cheadle, Rishum Khan, Hrishikesh Mane, Khandoker Samaher Salem, Katie Ernst, Adriana San Miguel, Charles H. Opperman, Tahira Pirzada, Nathan Crook, Saad A. Khan   +10 more
wiley   +1 more source

The landscape of expression and alternative splicing variation across human traits

Cell Genomics, 2023
Summary: Understanding the consequences of individual transcriptome variation is fundamental to deciphering human biology and disease. We implement a statistical framework to quantify the contributions of 21 individual traits as drivers of gene ...
Raquel García-Pérez, Jose Miguel Ramirez, Aida Ripoll-Cladellas, Ruben Chazarra-Gil, Winona Oliveros, Oleksandra Soldatkina, Mattia Bosio, Paul Joris Rognon, Salvador Capella-Gutierrez, Miquel Calvo, Ferran Reverter, Roderic Guigó, François Aguet, Pedro G. Ferreira, Kristin G. Ardlie, Marta Melé   +15 more
doaj  

Advanced Micro‐OLED Integration on Thin and Flexible Polymer Neural Probes for Targeted Optogenetic Stimulation

Advanced Functional Materials, EarlyView.
This paper introduces a flexible neural probe with integrated micro‐OLEDs on a flexible substrate for the first time, featuring 8 micro‐OLEDs and recording electrodes for optogenetics. It uses advanced encapsulation and an IAI anode for durability, emitting 470 nm light for ChR2 activation, enabling high‐resolution, minimally invasive stimulation ...
Somin Lee, Mi Kyung Kim, Seonil Kwon, Jia Chee Leong, Byeongju Noh, Junhee Sim, Eun Gyo Jeong, Hyunjoo J. Lee, Kyung Cheol Choi   +8 more
wiley   +1 more source

Activation of Neuroinflammation via mTOR Pathway is Disparately Regulated by Differential Target Multiplexed and Traditional Low-Rate Spinal Cord Stimulation in a Neuropathic Pain Model

Journal of Pain Research, 2022
Dana M Tilley,1 Ricardo Vallejo,1,2 Francesco Vetri,3 David C Platt,1,2 David L Cedeno1,2 1Research and Development, SGX Medical, Bloomington, IL, USA; 2Neuroscience, Illinois Wesleyan University, Bloomington, IL, USA; 3Research Department, National ...
Tilley DM, Vallejo R, Vetri F, Platt DC, Cedeno DL   +4 more
doaj  

Bioorthogonal Engineering of Cellular Microenvironments Using Isonitrile Ligations

Advanced Functional Materials, EarlyView.
Highly selective chemistries are required for fabrication and post‐cross–linking modification of cell‐encapsulating hydrogels used in tissue engineering applications. Isonitrile ligation reactions represent a promising class of bioorthogonal chemistries for engineering hydrogel‐based cellular microenvironments. Isonitrile‐based hydrogels are stable and
Ping Zhou, Lauren Brown, Christopher M. Madl   +2 more
wiley   +1 more source

Fabrication of ECM protein coated hollow collagen channels to study peripheral nerve regeneration

Scientific Reports
Peripheral nerve injury is a prevalent clinical problem that often leads to lifelong disability and reduced quality of life. Although peripheral nerves can regenerate, recovery after severe injury is slow and incomplete.
Jarin Tusnim, Karthik Budharaju, Jonathan M. Grasman   +2 more
doaj   +1 more source

Evaluation of In Vivo Subject-Specific Mechanical Modeling of the Optic Nerve Head for Robust Assessment of Ocular Mechanics [PDF]

arXiv
To establish the tissue regions necessary to accurately represent the mechanics of the optic nerve head (ONH), imaging data of the ONH from 2 healthy subjects were used to create in vivo subject-specific eye mechanical models considering distinct properties for all major ocular tissues.
arxiv  

Optimizing Angiopep‐2 Density on Polymeric Nanoparticles for Enhanced Blood–Brain Barrier Penetration and Glioblastoma Targeting: Insights From In Vitro and In Vivo Experiments

Advanced Functional Materials, EarlyView.
The Angiopep‐2 peptide density on polymeric nanoparticles significantly impacts blood–brain barrier (BBB) penetration. This study explores this nuanced relationship using various in vitro models and in vivo assays, revealing that dynamic models better predict BBB penetration.
Weisen Zhang, Ahmed Refaat, Haoqin Li, Douer Zhu, Ziqiu Tong, Joseph Anthony Nicolazzo, Bo Peng, Hua Bai, Lars Esser, Nicolas Hans Voelcker   +9 more
wiley   +1 more source

Estimated Incidence of Ophthalmic Conditions Associated with Optic Nerve Disease in Middle Tennessee [PDF]

arXiv, 2017
Aims. The objective of this paper is to determine the incidence of ophthalmic disease potentially leading to optic nerve disease in Middle Tennessee. Methods. We use a retrospective population-based incidence study design focusing on the population of middle Tennessee and its nearby suburbs (N=3 397 515). The electronic medical records for all patients
arxiv