Results 61 to 70 of about 3,905,054 (299)

Effects of Cyfluthrin Exposure on Neurobehaviour, Hippocampal Tissue and Synaptic Plasticity in Wistar Rats

Toxics, 2023
This experiment was conducted to study the effects of Cyfluthrin (Cy) exposure on neurobehaviour, hippocampal tissue and synaptic plasticity in Wistar rats.
Yongxin Xie, Ji Zhao, Xiaoyu Li, Jian Sun, Huifang Yang   +4 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

New insights into the interplay between autophagy and oxidative and endoplasmic reticulum stress in neuronal cell death and survival

Frontiers in Cell and Developmental Biology, 2022
Autophagy is a dynamic process that maintains the normal homeostasis of cells by digesting and degrading aging proteins and damaged organelles. The effect of autophagy on neural tissue is still a matter of debate.
Yahao Gao, Changshui Wang, Di Jiang, Gang An, Feng Jin, Junchen Zhang, Guangkui Han, Changmeng Cui, Pei Jiang   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Sub-Chronic Neuropathological and Biochemical Changes in Mouse Visual System after Repetitive Mild Traumatic Brain Injury. [PDF]

PLoS ONE, 2016
Repetitive mild traumatic brain injury (r-mTBI) results in neuropathological and biochemical consequences in the human visual system. Using a recently developed mouse model of r-mTBI, with control mice receiving repetitive anesthesia alone (r-sham) we ...
Radouil Tzekov, Clint Dawson, Megan Orlando, Benoit Mouzon, Jon Reed, James Evans, Gogce Crynen, Michael Mullan, Fiona Crawford   +8 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Willin, an upstream component of the Hippo signaling pathway, orchestrates mammalian peripheral nerve fibroblasts [PDF]

, 2013
Willin/FRMD6 was first identified in the rat sciatic nerve, which is composed of neurons, Schwann cells, and fibroblasts. Willin is an upstream component of the Hippo signaling pathway, which results in the inactivation of the transcriptional coactivator
Tilston-Lünel, A.M., Susan C Barnett, Gunn-Moore Frank J., Tilston-Lunel, Andrew Martin, Moleirinho, S., Jennifer R Higginson, Angus Liselotte, Prystowsky Michael B., Calum Patrick, Liselotte Angus, Andrew M. Tilston-lünel, Michael B. Prystowsky, Patrick, C., Susana Moleirinho, Frank J Gunn-Moore, Moleirinho Susana, Gunn-Moore, Frank J, Gunn-Moore, F.J., Prystowsky, M.B., Moleirinho, Susan, Paul A. Reynolds, Maciej Antkowiak, Susan C. Barnett, Jennifer R. Higginson, Antkowiak Maciej, Barnett Susan C., Paul A Reynolds, Higginson, J.R., Reynolds Paul A., Antkowiak, Maciej, Prystowsky, Michael, Michael B Prystowsky, Barnett, Susan, Antkowiak, M., Reynolds, Paul Andrew, Tilston-Lünel Andrew M., Barnett, S.C., Frank J. Gunn-moore, Angus, Liselotte, Andrew M Tilston-Lünel, Patrick Calum, Patrick, Calum, Higginson Jennifer R., Higginson, JR, Angus, L., Reynolds, P.A., Reynolds, Paul Andrew; id_orcid, Gunn-Moore, Frank J; id_orcid   +47 more
core   +2 more sources

Advances in stem cell therapy for sensory nerve injury

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Sensory nerves belong to the afferent nerve part of the peripheral nervous system. Their role is to accept the stimuli inside and outside the body and transmit them to the center nerve system to form sensations or reflexes.
CHEN Huidong, ZHANG Yunlong, ZHANG Zhijian, HUA Qingquan   +3 more
doaj   +1 more source

Matrilin-2, an extracellular adaptor protein, is needed for the regeneration of muscle, nerve and other tissues

Neural Regeneration Research, 2015
The extracellular matrix (ECM) performs essential functions in the differentiation, maintenance and remodeling of tissues during development and regeneration, and it undergoes dynamic changes during remodeling concomitant to alterations in the cell-ECM interactions.
Éva Korpos, Ferenc Deák, Ibolya Kiss
openaire   +3 more sources