Results 1 to 10 of about 25,652,950 (386)

DNA methylation-based classification of central nervous system tumours [PDF]

Nature, 2018
Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging—
D. Capper, David T. W. Jones, M. Sill, V. Hovestadt, D. Schrimpf, D. Sturm, C. Koelsche, F. Sahm, L. Chavez, D. Reuss, A. Kratz, A. Wefers, Kristin Huang, K. Pajtler, L. Schweizer, D. Stichel, A. Olar, Nils W. Engel, K. Lindenberg, P. Harter, Anne K. Braczynski, K. Plate, H. Dohmen, B. Garvalov, R. Coras, A. Hölsken, E. Hewer, M. Bewerunge-Hudler, M. Schick, R. Fischer, R. Beschorner, J. Schittenhelm, O. Staszewski, K. Wani, P. Varlet, M. Pages, P. Temming, D. Lohmann, F. Selt, H. Witt, T. Milde, O. Witt, E. Aronica, F. Giangaspero, E. Rushing, W. Scheurlen, C. Geisenberger, F. Rodriguez, A. Becker, M. Preusser, C. Haberler, R. Bjerkvig, J. Cryan, M. Farrell, M. Deckert, J. Hench, S. Frank, J. Serrano, Kasthuri Kannan, A. Tsirigos, W. Brück, S. Hofer, S. Brehmer, M. Seiz-Rosenhagen, D. Hänggi, V. Hans, S. Rozsnoki, J. Hansford, P. Kohlhof, B. Kristensen, M. Lechner, Beatriz Lopes, C. Mawrin, R. Ketter, A. Kulozik, Z. Khatib, F. Heppner, A. Koch, A. Jouvet, C. Keohane, H. Mühleisen, W. Müller, U. Pohl, M. Prinz, A. Benner, M. Zapatka, N. Gottardo, P. Driever, C. Kramm, H. Müller, S. Rutkowski, K. Hoff, M. Frühwald, A. Gnekow, G. Fleischhack, S. Tippelt, G. Calaminus, C. Monoranu, A. Perry, Chris Jones, T. Jacques, B. Radlwimmer, M. Gessi, T. Pietsch, J. Schramm, G. Schackert, M. Westphal, G. Reifenberger, P. Wesseling, M. Weller, V. Collins, I. Blümcke, M. Bendszus, J. Debus, A. Huang, N. Jabado, P. Northcott, W. Paulus, A. Gajjar, G. Robinson, Michael D. Taylor, Z. Jaunmuktane, M. Ryzhova, M. Platten, A. Unterberg, W. Wick, M. Karajannis, M. Mittelbronn, T. Acker, C. Hartmann, K. Aldape, U. Schüller, R. Buslei, P. Lichter, M. Kool, C. Herold‐Mende, D. Ellison, M. Hasselblatt, M. Snuderl, S. Brandner, A. Korshunov, A. Deimling, S. Pfister   +142 more
semanticscholar   +4 more sources

Fractals in the Nervous System: Conceptual Implications for Theoretical Neuroscience [PDF]

Front. Physiology, 2009
This essay is presented with two principal objectives in mind: first, to document the prevalence of fractals at all levels of the nervous system, giving credence to the notion of their functional relevance; and second, to draw attention to the as yet ...
Gerhard Werner
semanticscholar   +7 more sources

The 2021 WHO Classification of Tumors of the Central Nervous System: a summary.

Neuro-Oncology, 2021
The fifth edition of the WHO Classification of Tumors of the Central Nervous System (CNS), published in 2021, is the sixth version of the international standard for the classification of brain and spinal cord tumors.
D. Louis, A. Perry, P. Wesseling, D. Brat, I. Cree, D. Figarella-Branger, C. Hawkins, H. Ng, S. Pfister, G. Reifenberger, R. Soffietti, A. von Deimling, D. Ellison   +12 more
semanticscholar   +1 more source

Preclinical evaluation of Mito-LND, a targeting mitochondrial metabolism inhibitor, for glioblastoma treatment

Journal of Translational Medicine, 2023
Background Glioblastoma (GBM) is a brain tumor with the highest level of malignancy and the worst prognosis in the central nervous system. Mitochondrial metabolism plays a vital role in the occurrence and development of cancer, which provides critical ...
Tongxuan Guo, Changyong Wu, Lingni Zhou, Junhao Zhang, Wanzhou Wang, Yang Shen, Ludong Zhang, Mingshan Niu, Xu Zhang, Rutong Yu, Xuejiao Liu   +10 more
doaj   +1 more source

The nanoprodrug of polytemozolomide combines with MGMT siRNA to enhance the effect of temozolomide in glioma

Drug Delivery, 2023
Temozolomide (TMZ) is a conventional chemotherapeutic drug for glioma, however, its clinical application and efficacy is severely restricted by its drug resistance properties.
Haoyue Xu, Yongkang Zhang, Linfeng Li, Yanhong Ren, Feng Qian, Lansheng Wang, Hongwei Ma, Ankang Quan, Hongmei Liu, Rutong Yu   +9 more
doaj   +1 more source

YAP promotes autophagy and progression of gliomas via upregulating HMGB1

Journal of Experimental & Clinical Cancer Research, 2021
Background Due to the hypoxia and nutrient deficiency microenvironment, glioblastoma (GBM) exhibits high autophagy activity and autophagy plays an important role in the progression of GBM.
Min Zhao, Yu Zhang, Yang Jiang, Kai Wang, Xiang Wang, Ding Zhou, Yan Wang, Rutong Yu, Xiuping Zhou   +8 more
doaj   +1 more source

Dual blockade of EGFR and PI3K signaling pathways offers a therapeutic strategy for glioblastoma

Cell Communication and Signaling, 2023
Background Glioblastoma multiforme (GBM) is a devastating disease that lacks effective drugs for targeted therapy. Previously, we found that the third-generation epidermal growth factor receptor (EGFR) inhibitor AZD-9291 persistently blocked the ...
Tongxuan Guo, Changyong Wu, Junhao Zhang, Jiefeng Yu, Guoxi Li, Hongyan Jiang, Xu Zhang, Rutong Yu, Xuejiao Liu   +8 more
doaj   +1 more source

GRP78 blockade overcomes intrinsic resistance to UBA1 inhibitor TAK-243 in glioblastoma

Cell Death Discovery, 2022
Glioblastoma multiforme (GBM) is the most aggressive malignant primary brain tumor of the central nervous system. Despite continuous progression in treatment options for GBM like surgery, radiotherapy, and chemotherapy, this disease still has a high rate
Xu Zhang, Runqiu Wu, Cong Tian, Wanzhou Wang, Lingni Zhou, Tongxuan Guo, Jiefeng Yu, Changyong Wu, Yang Shen, Xuejiao Liu, Rutong Yu   +10 more
doaj   +1 more source

Chronic stress accelerates glioblastoma progression via DRD2/ERK/β-catenin axis and Dopamine/ERK/TH positive feedback loop

Journal of Experimental & Clinical Cancer Research, 2023
Background After diagnosis, glioblastoma (GBM) patients undertake tremendous psychological problems such as anxiety and depression, which may contribute to GBM progression.
Yan Wang, Xiang Wang, Kai Wang, Ji Qi, Yu Zhang, Xu Wang, Long Zhang, Yi Zhou, Linbo Gu, Rutong Yu, Xiuping Zhou   +10 more
doaj   +1 more source

Multi-responsive nanofibers composite gel for local drug delivery to inhibit recurrence of glioma after operation

Journal of Nanobiotechnology, 2021
Background The postoperative recurrence of malignant gliomas has presented a clinical conundrum currently. Worse, there is no standard treatment for these recurrent tumours.
Yufu Zhu, Jun Jia, Gang Zhao, Xuyang Huang, Lansheng Wang, Yongkang Zhang, Long Zhang, Naveena Konduru, Jun Xie, Rutong Yu, Hongmei Liu   +10 more
doaj   +1 more source