Results 21 to 30 of about 3,017,282 (362)

CRM1/XPO1 is associated with clinical outcome in glioma and represents a therapeutic target by perturbing multiple core pathways

open access: yesJournal of Hematology & Oncology, 2016
Background Malignant gliomas are associated with a high mortality rate, and effective treatment options are limited. Thus, the development of novel targeted treatments to battle this deadly disease is imperative.
Xuejiao Liu   +11 more
doaj   +1 more source

Macaque cardiac physiology is sensitive to the valence of passively viewed sensory stimuli. [PDF]

open access: yes, 2013
Autonomic nervous system activity is an important component of affective experience. We demonstrate in the rhesus monkey that both the sympathetic and parasympathetic branches of the autonomic nervous system respond differentially to the affective ...
Amaral, David G   +2 more
core   +2 more sources

Plumbagin inhibits growth of gliomas in vivo via suppression of FOXM1 expression

open access: yesJournal of Pharmacological Sciences, 2015
Plumbagin is a natural compound that is isolated from the root of the medicinal plant Plumbago zeylanica L. Based on a previous in vitro study performed by our group, which demonstrated the effectiveness of plumbagin against glioma cells, we further ...
Mingshan Niu   +9 more
doaj   +1 more source

Neural development and sensorimotor control [PDF]

open access: yes, 2004
What is the relationship between development of the nervous system and the emergence of voluntary motor behavior? This is the central question of the nature-nurture discussion that has intrigued child psychologists and pediatric neurologists for decades.
Konczak, Jürgen
core   +2 more sources

Anti-MOG associated myelitis

open access: yesНеврология, нейропсихиатрия, психосоматика, 2020
There is now increasing evidence that demyelinating disease with anti-myelin oligodendrocyte glycoprotein (anti-MOG) antibodies is an independent nosological unit.
A. I. Isaykin   +4 more
doaj   +1 more source

The Many Hats of Sonic Hedgehog Signaling in Nervous System Development and Disease. [PDF]

open access: yes, 2016
Sonic hedgehog (Shh) signaling occurs concurrently with the many processes that constitute nervous system development. Although Shh is mostly known for its proliferative and morphogenic action through its effects on neural stem cells and progenitors, it ...
Belgacem, Yesser H   +4 more
core   +2 more sources

The functional diversity of Aurora kinases: a comprehensive review

open access: yesCell Division, 2018
Aurora kinases are serine/threonine kinases essential for the onset and progression of mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit distinct cellular and subcellular localization.
Estelle Willems   +5 more
doaj   +1 more source

The third-generation EGFR inhibitor AZD9291 overcomes primary resistance by continuously blocking ERK signaling in glioblastoma

open access: yesJournal of Experimental & Clinical Cancer Research, 2019
Background Glioblastoma (GBM) is a fatal brain tumor, lacking effective treatment. Epidermal growth factor receptor (EGFR) is recognized as an attractive target for GBM treatment. However, GBMs have very poor responses to the first- and second-generation
Xuejiao Liu   +11 more
doaj   +1 more source

A zinc transporter gene required for development of the nervous system. [PDF]

open access: yes, 2013
The essentiality of zinc for normal brain development is well established. It has been suggested that primary and secondary zinc deficiencies can contribute to the occurrence of numerous human birth defects, including many involving the central nervous ...
Chowanadisai, Winyoo   +4 more
core   +1 more source

Nervous System Hemangiopericytoma [PDF]

open access: yesCanadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2019
Abstract:The management of patients harboring central nervous system (CNS) hemangiopericytomas (HPCs) is a partially answered challenge. These are rare locally aggressive lesions, with potential for local recurrence, distal neural metastasis (DNM), and extraneural metastasis (ENM).
openaire   +2 more sources

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