Results 111 to 120 of about 3,017,282 (362)

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Advances in the Optimization of CAR-T-Cell-Based Therapeutic Approaches to Enhance Antitumor Efficacy in Glioblastoma Treatment

Oncology and Therapy
Chimeric antigen receptor (CAR)-T cell therapy is emerging as a promising immunotherapeutic modality for improving clinical outcomes in high-grade gliomas.
Lidia Gatto, Vincenzo Di Nunno, Alicia Tosoni, Marta Aprile, Chiara Maria Argento, Marzia Margotti, Stefania Bartolini, Enrico Franceschi   +7 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

The central vein sign in the diagnosis of multiple sclerosis

Неврология, нейропсихиатрия, психосоматика
Objective: to determine the specificity and sensitivity of the central vein sign (CVS) for the diagnosis of multiple sclerosis (MS). Material and methods. We analyzed 76 patients.
Sh. R. Nabiev, S. A. Dzhukkaeva, M. Sh. Asvedov, O. N. Voskresenskaya   +3 more
doaj   +1 more source

Central nervous system toxoplasmosis in an immunocompetent individual [PDF]

, 2019
Huai Jan Chang, Chien‐Tai Hong, Chaur‐Jong Hu, Lung Chan   +3 more
openalex   +1 more source

Electrophysiological studies of the nervous system [PDF]

The electrophysiology of the nervous system is studied using cats and human subjects. Data cover effects of chlorolose on evoked potential, the evoked resistance shift that accompanies evoked potentials, and the relationship of eye movements to ...
Galambos, R.
core   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

An integrated perspective on single-cell and spatial transcriptomic signatures in high-grade gliomas

npj Precision Oncology
High-grade gliomas (HGG) are incurable brain malignancies in children and adults. Breakthrough advances in transcriptomic technologies unveiled the intricate diversity of cellular states and their spatial organization within HGGs.
Célia Lemoine, Marc-Antoine Da Veiga, Bernard Rogister, Caroline Piette, Virginie Neirinckx   +4 more
doaj   +1 more source

DNA methylation-based classification of central nervous system tumours. [PDF]

, 2018
Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging-
Aronica, Eleonora, Becker, Albert, Benner, Axel, Beschorner, Rudi, Bewerunge-Hudler, Melanie, Bjerkvig, Rolf, Braczynski, Anne K, Brehmer, Stefanie, Brück, Wolfgang, Calaminus, Gabriele, Capper, David, Chavez, Lukas, Coras, Roland, Cryan, Jane, Deckert, Martina, Dohmen, Hildegard, Driever, Pablo Hernáiz, Engel, Nils W, Farrell, Michael, Fischer, Roger, Fleischhack, Gudrun, Frank, Stephan, Frühwald, Michael C, Garvalov, Boyan K, Geisenberger, Christoph, Giangaspero, Felice, Gnekow, Astrid, Gottardo, Nicholas G, Haberler, Christine, Hans, Volkmar, Hansford, Jordan R, Harter, Patrick N, Hench, Jürgen, Heppner, Frank, Hewer, Ekkehard, Hofer, Silvia, Hovestadt, Volker, Huang, Kristin, Hänggi, Daniel, Hölsken, Annett, Jones, Chris, Jones, David TW, Jouvet, Anne, Kannan, Kasthuri, Keohane, Catherine, Ketter, Ralf, Khatib, Ziad, Koch, Arend, Koelsche, Christian, Kohlhof, Patricia, Kramm, Christof M, Kratz, Annekathrin, Kristensen, Bjarne W, Kulozik, Andreas, Lechner, Matt, Lindenberg, Kerstin, Lohmann, Dietmar, Lopes, Beatriz, Mawrin, Christian, Milde, Till, Monoranu, Camelia-Maria, Mueller, Wolf, Mühleisen, Helmut, Müller, Hermann L, Olar, Adriana, Pages, Melanie, Pajtler, Kristian W, Perry, Arie, Plate, Karl H, Pohl, Ute, Preusser, Matthias, Prinz, Marco, Reuss, David E, Rodriguez, Fausto J, Rozsnoki, Stephanie, Rushing, Elisabeth, Rutkowski, Stefan, Sahm, Felix, Scheurlen, Wolfram, Schick, Matthias, Schittenhelm, Jens, Schrimpf, Daniel, Schweizer, Leonille, Seiz-Rosenhagen, Marcel, Selt, Florian, Serrano, Jonathan, Sill, Martin, Staszewski, Ori, Stichel, Damian, Sturm, Dominik, Temming, Petra, Tippelt, Stephan, Tsirigos, Aristotelis, Varlet, Pascale, von Hoff, Katja, Wani, Khalida, Wefers, Annika K, Witt, Hendrik, Witt, Olaf, Zapatka, Marc   +99 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source