Results 21 to 30 of about 23,851,532 (246)
Molecular Architecture of the Mouse Nervous System
Cell, 2018 The mammalian nervous system executes complex behaviors controlled by specialised, precisely positioned and interacting cell types. Here, we used RNA sequencing of half a million single cells to create a detailed census of cell types in the mouse nervous
Amit Zeisel +19 more
semanticscholar +1 more source
Molecular topography of an entire nervous system
Cell, 2020 Nervous systems are constructed from a deep repertoire of neuron types but the underlying gene expression programs that specify individual neuron identities are poorly understood. To address this deficit, we have produced an expression profile of all 302
Seth R. Taylor +22 more
semanticscholar +1 more source
Lipid droplets in the nervous system
Journal of Cell Biology, 2021 Ralhan et al. review the emerging role of lipid droplets in the nervous system in development, aging, and disease.
Isha Ralhan +3 more
semanticscholar +1 more source
Journal of Hematology & Oncology, 2016 Background Malignant gliomas are associated with a high mortality rate, and effective treatment options are limited. Thus, the development of novel targeted treatments to battle this deadly disease is imperative.
Xuejiao Liu +11 more
doaj +1 more source
DNA methylation-based classification of central nervous system tumours
Nature, 2018 Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging—
D. Capper +142 more
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Elementary nervous systems [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2021 The evolutionary origin of the nervous system has been a matter of long-standing debate. This is due to the different perspectives taken. Earlier studies addressed nervous system origins at the cellular level. They focused on the selective advantage of the first neuron in its local context, and considered vertical sensory-motor reflex arcs the first ...
openaire +3 more sources
Plumbagin inhibits growth of gliomas in vivo via suppression of FOXM1 expression
Journal of Pharmacological Sciences, 2015 Plumbagin is a natural compound that is isolated from the root of the medicinal plant Plumbago zeylanica L. Based on a previous in vitro study performed by our group, which demonstrated the effectiveness of plumbagin against glioma cells, we further ...
Mingshan Niu +9 more
doaj +1 more source
COVID‐19: A Global Threat to the Nervous System
Annals of Neurology, 2020 In less than 6 months, the severe acute respiratory syndrome‐coronavirus type 2 (SARS‐CoV‐2) has spread worldwide infecting nearly 6 million people and killing over 350,000.
I. Koralnik, K. Tyler
semanticscholar +1 more source
The functional diversity of Aurora kinases: a comprehensive review
Cell Division, 2018 Aurora kinases are serine/threonine kinases essential for the onset and progression of mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit distinct cellular and subcellular localization.
Estelle Willems +5 more
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Journal of Experimental & Clinical Cancer Research, 2019 Background Glioblastoma (GBM) is a fatal brain tumor, lacking effective treatment. Epidermal growth factor receptor (EGFR) is recognized as an attractive target for GBM treatment. However, GBMs have very poor responses to the first- and second-generation
Xuejiao Liu +11 more
doaj +1 more source