Results 31 to 40 of about 354,249 (306)

Whole genome sequencing-based mapping and candidate identification of mutations from fixed zebrafish tissue [PDF]

, 2017
As forward genetic screens in zebrafish become more common, the number of mutants that cannot be identified by gross morphology or through transgenic approaches, such as many nervous system defects, has also increased.
Ackerman, Sarah D, Gray, Ryan S, Harty, Breanne L, Herbert, Amy L, Holmgren, Melanie, Johnson, Stephen L, Monk, Kelly R, O\u27Reilly-Pol, Thomas, Sanchez, Nicholas E   +8 more
core   +3 more sources

Fetal akinesia deformation sequence with pontocerebellar hypoplasia, and migration and gyration defects

Autopsy and Case Reports, 2021
Fetal akinesia deformation sequence (FADS), or Pena-Shokeir phenotype is a constellation of deformational changes resulting from decreased or absent fetal movement, and include arthrogryposis, and craniofacial and central nervous system anomalies.
Meghan Elizabeth Kapp, Pamela Lyle, Hilary Highfield Nickols   +2 more
doaj  

Slit/Robo Signaling Regulates Multiple Stages of the Development of the Drosophila Motion Detection System

Frontiers in Cell and Developmental Biology, 2021
Neurogenesis is achieved through a sequence of steps that include specification and differentiation of progenitors into mature neurons. Frequently, precursors migrate to distinct positions before terminal differentiation. The Slit-Robo pathway, formed by
Pablo Guzmán-Palma, Esteban G. Contreras, Natalia Mora, Macarena Smith, M. Constanza González-Ramírez, Jorge M. Campusano, Jimena Sierralta, Bassem A. Hassan, Carlos Oliva   +8 more
doaj   +1 more source

PO-0451 Defects Of Central Nervous System: A Review [PDF]

Archives of Disease in Childhood, 2014
Background and aims Central nervous system (CNS) appears in the 3rd week of development, derived from the ectodermal sheet and from the neural plate. The frequency of CNS abnormalities ranges from 0.8 to 1.3/100 live births, and neural tube defects (NTD) are the most common.
C Castillo Rukoz, M Salamanca Campos, S López Agullo, L Sabonet Morente, A Sanchis Calvo   +4 more
openaire   +1 more source

Involvement of deprivation and environmental lead in neural tube defects:a matched case-control study. [PDF]

, 2009
OBJECTIVE. To analyse the prevalence of neural tube defects in small geographical areas and seek to explain any spatial variations with reference to environmental lead and deprivation. SETTING.
Awwad, Fuad, Bound, John P., Francis, Brian J., Gatrell, Tony, Harvey, Peter W.   +4 more
core   +1 more source

Nav2 is necessary for cranial nerve development and blood pressure regulation [PDF]

, 2010
Background All-trans retinoic acid (atRA) is required for nervous system development, including the developing hindbrain region. Neuron navigator 2 (Nav2) was first identified as an atRA-responsive gene in human neuroblastoma cells (retinoic acid-induced
Elizabeth M McNeill, Kenneth P Roos, Dieder Moechars, Margaret Clagett-Dame   +3 more
core   +2 more sources

Maternal inheritance of twist and analysis of MAPK activation in embryos of the polychaete Annelid Platynereis dumerilii [PDF]

, 2014
In this study, we aimed to identify molecular mechanisms involved in the specification of the 4d (mesentoblast) lineage in Platynereis dumerilii. We employ RT-PCR and in situ hybridization against the Platynereis dumerilii twist homolog (Pdu-twist) to ...
Domsch, Katrin, Dorresteijn, Adriaan, Pfeifer, Kathrin, Schaub, Christoph, Wolfstetter, Georg   +4 more
core   +3 more sources

Defective cholesterol clearance limits remyelination in the aged central nervous system [PDF]

Science, 2018
Keeping cholesterol at bay A decline in tissue repair is a universal hallmark of aging. The failure to regenerate myelin sheaths in multiple sclerosis lesions contributes to chronic progressive disease and disability.
Cantuti-Castelvetri, Ludovico, Fitzner, Dirk, Bosch-Queralt, Mar, Weil, Marie-Theres, Su, Minhui, Sen, Paromita, Ruhwedel, Torben, Mitkovski, Miso, Trendelenburg, George, Lütjohann, Dieter, Möbius, Wiebke, Simons, Mikael   +11 more
openaire   +5 more sources

Pinpointing brainstem mechanisms responsible for autonomic dysfunction in Rett syndrome:therapeutic perspectives for 5-HT1A agonists [PDF]

, 2014
Rett syndrome is a neurological disorder caused by loss of function of methyl-CpG-binding protein 2 (MeCP2). Reduced function of this ubiquitous transcriptional regulator has a devastating effect on the central nervous system.
Abdala, Ana Paula, Bissonnette, John, Newman-Tancredi, Adrian   +2 more
core   +3 more sources

Single-cell multi-omics analysis reveals cellular subpopulations associated with relapse in high-risk B-ALL following intensified chemotherapy

Frontiers in Immunology
IntroductionAcute lymphoblastic leukemia (ALL) is the most prevalent malignant tumor in children, with B-cell ALL (B-ALL) accounting for 85% of cases. Despite advancements in chemotherapy and supportive care, a subset of high-risk B-ALL patients still ...
Li Liu, Xiaoyan Mao, Chunhui Yang, Na Li, Yan Zhou, Li Zhang, Nanjing Jiang, Yu Huang, Shigang Yin, Shigang Yin, Huangfan Xie, Huangfan Xie, Xin Tian   +12 more
doaj   +1 more source