Results 11 to 20 of about 2,814,068 (394)
CNS Neuroscience & Therapeutics, 2023 Mitochondria is one of the important organelles involved in cell energy metabolism and regulation and also play a key regulatory role in abnormal cell processes such as cell stress, cell damage, and cell canceration.
Ziang Geng +6 more
semanticscholar +1 more source
The regulatory role of lipophagy in central nervous system diseases
Cell Death Discovery, 2023 Lipid droplets (LDs) are the organelles for storing neutral lipids, which are broken down when energy is insufficient. It has been suggested that excessive accumulation of LDs can affect cellular function, which is important to coordinate homeostasis of ...
Zhu Lan +4 more
semanticscholar +1 more source
YAP promotes autophagy and progression of gliomas via upregulating HMGB1
Journal of Experimental & Clinical Cancer Research, 2021 Background Due to the hypoxia and nutrient deficiency microenvironment, glioblastoma (GBM) exhibits high autophagy activity and autophagy plays an important role in the progression of GBM.
Min Zhao +8 more
doaj +1 more source
Drug Delivery, 2023 Temozolomide (TMZ) is a conventional chemotherapeutic drug for glioma, however, its clinical application and efficacy is severely restricted by its drug resistance properties.
Haoyue Xu +9 more
doaj +1 more source
Dual blockade of EGFR and PI3K signaling pathways offers a therapeutic strategy for glioblastoma
Cell Communication and Signaling, 2023 Background Glioblastoma multiforme (GBM) is a devastating disease that lacks effective drugs for targeted therapy. Previously, we found that the third-generation epidermal growth factor receptor (EGFR) inhibitor AZD-9291 persistently blocked the ...
Tongxuan Guo +8 more
doaj +1 more source
A Manual of Diseases of the Nervous System
The Journal of Nervous and Mental Disease, 1894 JC
openalex +5 more sources
New Insights into the Roles of p53 in Central Nervous System Diseases
International Journal of Neuropsychopharmacology, 2023 The transcription factor p53, a widely accepted tumor suppressor, regulates the expression of many oncogenes and their downstream signaling pathways, resulting in a series of biological outcomes.
Haili Li +4 more
semanticscholar +1 more source
GRP78 blockade overcomes intrinsic resistance to UBA1 inhibitor TAK-243 in glioblastoma
Cell Death Discovery, 2022 Glioblastoma multiforme (GBM) is the most aggressive malignant primary brain tumor of the central nervous system. Despite continuous progression in treatment options for GBM like surgery, radiotherapy, and chemotherapy, this disease still has a high rate
Xu Zhang +10 more
doaj +1 more source
Role of exosomes in the pathogenesis, diagnosis, and treatment of central nervous system diseases
Journal of Translational Medicine, 2022 Central nervous system (CNS) diseases, such as multiple sclerosis, Alzheimer's disease (AD), and Parkinson’s disease (PD), affect millions of people around the world.
Yishu Fan, Zhuohui Chen, Mengqi Zhang
semanticscholar +1 more source
Journal of Experimental & Clinical Cancer Research, 2023 Background After diagnosis, glioblastoma (GBM) patients undertake tremendous psychological problems such as anxiety and depression, which may contribute to GBM progression.
Yan Wang +10 more
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