Results 11 to 20 of about 2,389,964 (125)

Dual blockade of EGFR and PI3K signaling pathways offers a therapeutic strategy for glioblastoma

Cell Communication and Signaling, 2023
Background Glioblastoma multiforme (GBM) is a devastating disease that lacks effective drugs for targeted therapy. Previously, we found that the third-generation epidermal growth factor receptor (EGFR) inhibitor AZD-9291 persistently blocked the ...
Tongxuan Guo, Changyong Wu, Junhao Zhang, Jiefeng Yu, Guoxi Li, Hongyan Jiang, Xu Zhang, Rutong Yu, Xuejiao Liu   +8 more
doaj   +1 more source

The role of gamma oscillations in central nervous system diseases: Mechanism and treatment

Frontiers in Cellular Neuroscience, 2022
Gamma oscillation is the synchronization with a frequency of 30–90 Hz of neural oscillations, which are rhythmic electric processes of neuron groups in the brain.
Ao Guan, Shaoshuang Wang, Ailing Huang, Chenyue Qiu, Yansong Li, Xuying Li, Jinfei Wang, Qiang Wang, Bin Deng   +8 more
semanticscholar   +1 more source

GRP78 blockade overcomes intrinsic resistance to UBA1 inhibitor TAK-243 in glioblastoma

Cell Death Discovery, 2022
Glioblastoma multiforme (GBM) is the most aggressive malignant primary brain tumor of the central nervous system. Despite continuous progression in treatment options for GBM like surgery, radiotherapy, and chemotherapy, this disease still has a high rate
Xu Zhang, Runqiu Wu, Cong Tian, Wanzhou Wang, Lingni Zhou, Tongxuan Guo, Jiefeng Yu, Changyong Wu, Yang Shen, Xuejiao Liu, Rutong Yu   +10 more
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Neuroprotective Mechanisms of Ginsenoside Rb1 in Central Nervous System Diseases

Frontiers in Pharmacology, 2022
Panax ginseng and Panax notoginseng, two well-known herbs with enormous medical value in Asian countries, have a long usage history in China for the therapy of some diseases, such as stroke.
L. Gong, Jiayi Yin, Yu Zhang, Ren Huang, Y. Lou, Haojie Jiang, Liyan Sun, Jinjing Jia, Xiansi Zeng   +8 more
semanticscholar   +1 more source

Phosphatidylserine, inflammation, and central nervous system diseases

Frontiers in Aging Neuroscience, 2022
Phosphatidylserine (PS) is an anionic phospholipid in the eukaryotic membrane and is abundant in the brain. Accumulated studies have revealed that PS is involved in the multiple functions of the brain, such as activation of membrane signaling pathways ...
Xiaohua Ma, Xiaojing Li, Wenjuan Wang, Meng Zhang, Bo Yang, Z. Miao   +5 more
semanticscholar   +1 more source

Chronic stress accelerates glioblastoma progression via DRD2/ERK/β-catenin axis and Dopamine/ERK/TH positive feedback loop

Journal of Experimental & Clinical Cancer Research, 2023
Background After diagnosis, glioblastoma (GBM) patients undertake tremendous psychological problems such as anxiety and depression, which may contribute to GBM progression.
Yan Wang, Xiang Wang, Kai Wang, Ji Qi, Yu Zhang, Xu Wang, Long Zhang, Yi Zhou, Linbo Gu, Rutong Yu, Xiuping Zhou   +10 more
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Vimentin as a potential target for diverse nervous system diseases

Neural Regeneration Research, 2022
Vimentin is a major type III intermediate filament protein that plays important roles in several basic cellular functions including cell migration, proliferation, and division.
Kangzhen Chen, Shuxian Liu, Yan-Wei Li, Tao He, Jie Zhao, Tao Wang, Xiangyan Qiu, Hong-Fu Wu   +7 more
semanticscholar   +1 more source

Ferroptosis and Its Potential Role in the Nervous System Diseases

Journal of Inflammation Research, 2022
Ferroptosis is a novel regulated cell death characterized by metabolic disorders and iron-dependent oxidative destruction of the lipid bilayer. It is primarily caused by the imbalance of oxidation and anti-oxidation in the body and is precisely regulated
Yiyang Zhou, Wei Lin, T. Rao, Jinyu Zheng, Tianlei Zhang, Min Zhang, Zhenlang Lin   +6 more
semanticscholar   +1 more source

Multi-responsive nanofibers composite gel for local drug delivery to inhibit recurrence of glioma after operation

Journal of Nanobiotechnology, 2021
Background The postoperative recurrence of malignant gliomas has presented a clinical conundrum currently. Worse, there is no standard treatment for these recurrent tumours.
Yufu Zhu, Jun Jia, Gang Zhao, Xuyang Huang, Lansheng Wang, Yongkang Zhang, Long Zhang, Naveena Konduru, Jun Xie, Rutong Yu, Hongmei Liu   +10 more
doaj   +1 more source

Delivering the Promise of Gene Therapy with Nanomedicines in Treating Central Nervous System Diseases

Advancement of science, 2022
Central Nervous System (CNS) diseases, such as Alzheimer's diseases (AD), Parkinson's Diseases (PD), brain tumors, Huntington's disease (HD), and stroke, still remain difficult to treat by the conventional molecular drugs.
Meihua Luo, L. Lee, Bo Peng, C. H. J. Choi, W. Tong, N. Voelcker   +5 more
semanticscholar   +1 more source