Results 21 to 30 of about 2,663,952 (341)
The regulatory role of lipophagy in central nervous system diseases
Cell Death Discovery, 2023 Lipid droplets (LDs) are the organelles for storing neutral lipids, which are broken down when energy is insufficient. It has been suggested that excessive accumulation of LDs can affect cellular function, which is important to coordinate homeostasis of ...
Zhu Lan +4 more
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New Insights into the Roles of p53 in Central Nervous System Diseases
International Journal of Neuropsychopharmacology, 2023 The transcription factor p53, a widely accepted tumor suppressor, regulates the expression of many oncogenes and their downstream signaling pathways, resulting in a series of biological outcomes.
Haili Li +4 more
semanticscholar +1 more source
Intranasal administration of stem cell-derived exosomes for central nervous system diseases
Neural Regeneration Research, 2023 Exosomes, lipid bilayer-enclosed small cellular vesicles, are actively secreted by various cells and play crucial roles in intercellular communication. These nanosized vesicles transport internalized proteins, mRNA, miRNA, and other bioactive molecules ...
Shuho Gotoh, M. Kawabori, Miki Fujimura
semanticscholar +1 more source
Phosphatidylserine, inflammation, and central nervous system diseases
Frontiers in Aging Neuroscience, 2022 Phosphatidylserine (PS) is an anionic phospholipid in the eukaryotic membrane and is abundant in the brain. Accumulated studies have revealed that PS is involved in the multiple functions of the brain, such as activation of membrane signaling pathways ...
Xiaohua Ma +5 more
semanticscholar +1 more source
Advancement of science, 2022 Central Nervous System (CNS) diseases, such as Alzheimer's diseases (AD), Parkinson's Diseases (PD), brain tumors, Huntington's disease (HD), and stroke, still remain difficult to treat by the conventional molecular drugs.
Meihua Luo +5 more
semanticscholar +1 more source
Neuroprotective Mechanisms of Ginsenoside Rb1 in Central Nervous System Diseases
Frontiers in Pharmacology, 2022 Panax ginseng and Panax notoginseng, two well-known herbs with enormous medical value in Asian countries, have a long usage history in China for the therapy of some diseases, such as stroke.
L. Gong +8 more
semanticscholar +1 more source
Vimentin as a potential target for diverse nervous system diseases
Neural Regeneration Research, 2022 Vimentin is a major type III intermediate filament protein that plays important roles in several basic cellular functions including cell migration, proliferation, and division.
Kangzhen Chen +7 more
semanticscholar +1 more source
Meningeal Lymphatics in Central Nervous System Diseases. [PDF]
Annu Rev NeurosciSince its recent discovery, the meningeal lymphatic system has reshaped our understanding of central nervous system (CNS) fluid exchange, waste clearance, immune cell trafficking, and immune privilege.
Salvador AFM, Abduljawad N, Kipnis J.
europepmc +2 more sources
Неврология, нейропсихиатрия, психосоматика, 2020 There is now increasing evidence that demyelinating disease with anti-myelin oligodendrocyte glycoprotein (anti-MOG) antibodies is an independent nosological unit.
A. I. Isaykin +4 more
doaj +1 more source
Ferroptosis and Its Potential Role in the Nervous System Diseases
Journal of Inflammation Research, 2022 Ferroptosis is a novel regulated cell death characterized by metabolic disorders and iron-dependent oxidative destruction of the lipid bilayer. It is primarily caused by the imbalance of oxidation and anti-oxidation in the body and is precisely regulated
Yiyang Zhou +6 more
semanticscholar +1 more source