Results 21 to 30 of about 1,521,520 (50)
Medicinal research reviews (Print), 2020 Neurological disorders significantly outnumber diseases in other therapeutic areas. However, developing drugs for central nervous system (CNS) disorders remains the most challenging area in drug discovery, accompanied with the long timelines and high ...
Sezen Vatansever +6 more
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The Role of Mfsd2a in Nervous System Diseases
Frontiers in Neuroscience, 2021 Major facilitator superfamily (MFS) is the maximum and most diversified membrane transporter, acting as uniporters, symporters and antiporters. MFS is considered to have a good development potential in the transport of drugs for the treatment of brain ...
B. Huang, Xihong Li
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Epidemiology and Infection, 2021 Coronavirus disease 2019 (COVID-19) has become a global pandemic. Previous studies showed that comorbidities in patients with COVID-19 are risk factors for adverse outcomes.
Ya Gao +6 more
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The Role of GM130 in Nervous System Diseases
Frontiers in Neurology, 2021 Golgi matrix protein 130 (GM130) is a Golgi-shaping protein located on the cis surface of the Golgi apparatus (GA). It is one of the most studied Golgin proteins so far.
B. Huang, Xihong Li, Xiaoshi Zhu
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Siah1 in cancer and nervous system diseases (Review).
Oncology Report, 2021 The dysregulation of the ubiquitin‑proteasome system will result in the abnormal accumulation and dysfunction of proteins, thus leading to severe diseases.
Hui Zhang +4 more
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Current pharmaceutical design, 2020 An important goal of biomedical research is to translate basic research findings into practical clinical implementation. Despite the advances in the technology used in drug discovery, the development of drugs for central nervous system diseases remains ...
Y. Morofuji, Shinsuke Nakagawa
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Bioprinting Neural Systems to Model Central Nervous System Diseases
Advanced Functional Materials, 2020 To date, pharmaceutical progresses in central nervous system (CNS) diseases are clearly hampered by the lack of suitable disease models. Indeed, animal models do not faithfully represent human neurodegenerative processes and human in vitro 2D cell ...
Boning Qiu +7 more
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Role of Exosomes in Central Nervous System Diseases
Frontiers in Molecular Neuroscience, 2019 There are many types of intercellular communication, and extracellular vesicles are one of the important forms of this. They are released by a variety of cell types, are heterogeneous, and can roughly be divided into microvesicles and exosomes according ...
Wanying Liu +5 more
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Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases
Frontiers in Pharmacology, 2020 Ferroptosis is a new form of programmed cell death characterized by intracellular iron-dependent accumulation of lipid peroxide and primarily associated with iron metabolism, glutathione-dependent pathway, and coenzyme Q10-dependent pathway.
Qingyun Tan, Yuying Fang, Qiong Gu
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International Journal of Molecular Sciences, 2020 Acupuncture is clinically used to treat various diseases and exerts positive local and systemic effects in several nervous system diseases. Advanced molecular and clinical studies have continually attempted to decipher the mechanisms underlying these ...
Tzu-Hsuan Wei, C. Hsieh
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