Results 51 to 60 of about 2,389,964 (125)
Matrix metalloproteinases as new targets in Alzheimer's disease: Opportunities and Challenges [PDF]
Journal of Medicinal Chemistry, American Chemical Society, 2020, 2021 Although matrix metalloproteinases (MMPs) are implicated in the regulation of numerous physiological processes, evidences of their pathological roles have also been obtained in the last decades, making MMPs attractive therapeutic targets for several diseases.
arxiv
Current pharmaceutical design, 2020 An important goal of biomedical research is to translate basic research findings into practical clinical implementation. Despite the advances in the technology used in drug discovery, the development of drugs for central nervous system diseases remains ...
Y. Morofuji, Shinsuke Nakagawa
semanticscholar +1 more source
Stratification of the phase clouds and statistical effects of the non-Markovity in chaotic time series of human gait for healthy people and Parkinson patients [PDF]
Physica A 319 2003, 432-446, 2004 In this work we develop a new method of diagnosing the nervous system diseases and a new approach in studying human gait dynamics with the help of the theory of discrete non-Markov random processes. The stratification of the phase clouds and the statistical non-Markov effects in the time series of the dynamics of human gait are considered.
arxiv +1 more source
Cognitive impairments in patients with prior ischemic stroke
Неврология, нейропсихиатрия, психосоматика, 2014 The authors give the data available in the literature on and the results of their studies of the epidemiology, risk factors, pathogenesis, diagnosis, and treatment of poststroke cognitive impairment (PSCI).
V. A. Parfenov +4 more
doaj +1 more source
Central pontine myelinolysis in the presence of SARS-CoV-2 infection (clinical observations)
Неврология, нейропсихиатрия, психосоматика, 2021 Osmotic demyelinating syndrome (ODS) is a severe complication that occurs due to rapid correction of hyponatremia. Central pontine myelinolysis (CPM), in which a focus of demyelination occurs in the pontine region, and extrapontine myelinolysis (EPM),
O. N. Voskresenskaya +5 more
doaj +1 more source
Role of Exosomes in Central Nervous System Diseases
Frontiers in Molecular Neuroscience, 2019 There are many types of intercellular communication, and extracellular vesicles are one of the important forms of this. They are released by a variety of cell types, are heterogeneous, and can roughly be divided into microvesicles and exosomes according ...
Wanying Liu +5 more
semanticscholar +1 more source
Bioprinting Neural Systems to Model Central Nervous System Diseases
Advanced Functional Materials, 2020 To date, pharmaceutical progresses in central nervous system (CNS) diseases are clearly hampered by the lack of suitable disease models. Indeed, animal models do not faithfully represent human neurodegenerative processes and human in vitro 2D cell ...
Boning Qiu +7 more
semanticscholar +1 more source
Journal of NanobiotechnologyBackground The Hippo pathway is a conserved tumour suppressor signalling pathway, and its dysregulation is often associated with abnormal cell growth and tumorigenesis.
Ji Qi +11 more
doaj +1 more source
Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases
Frontiers in Pharmacology, 2020 Ferroptosis is a new form of programmed cell death characterized by intracellular iron-dependent accumulation of lipid peroxide and primarily associated with iron metabolism, glutathione-dependent pathway, and coenzyme Q10-dependent pathway.
Qingyun Tan, Yuying Fang, Qiong Gu
semanticscholar +1 more source
International Journal of Molecular Sciences, 2020 Acupuncture is clinically used to treat various diseases and exerts positive local and systemic effects in several nervous system diseases. Advanced molecular and clinical studies have continually attempted to decipher the mechanisms underlying these ...
Tzu-Hsuan Wei, C. Hsieh
semanticscholar +1 more source