Results 51 to 60 of about 1,541,460 (327)

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Long-term survival for a cohort of adults with cerebral palsy [PDF]

, 2006
The aim of this study was to investigate long-term survival and examine causes of death in adult patients with cerebral palsy (CP). A 1940–1950 birth cohort based on paediatric case referral allows for long-term survival follow-up.
Blair, Cox, Evans, Evans, Hutton, Hutton, Hutton, Jane L Hutton, Karla Hemming, Maudsley, Peter O D Pharoah, Strauss, Strauss, Strauss, Strauss, Surveillance of Cerebral Palsy in Europe., Woods, Woods, Woods   +18 more
core   +1 more source

The Influence of Heredity on Disease, with Special Reference to Tuberculosis, Cancer and Diseases of the Nervous System [PDF]

, 1909
Bashford
  +8 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

A Small Conductance Calcium-Activated K⁺ Channel in C. elegans, KCNL-2, Plays a Role in the Regulation of the Rate of Egg-Laying [PDF]

, 2013
In the nervous system of mice, small conductance calcium-activated potassium (SK) channels function to regulate neuronal excitability through the generation of a component of the medium afterhyperpolarization that follows action potentials.
A Calixto, A Singson, AC Gerlach, Cavita K. Chotoo, CC Mello, CI Bargmann, Cliff J. Luke, CM Fanger, CT Bond, D Fernández de Sevilla, Daniel C. Devor, ER Sawin, F Simmer, Gary A. Silverman, GM Herrera, IA Bany, J Kim, J Kyte, J Wolfart, JE Mendel, JG White, Jill C Bettinger, JJ Moresco, JP Adelman, JT Walter, KS Thorneloe, L Ségalat, M Dimitriadi, M Köhler, M Stocker, M Szatanik, M Zhang, MJ Miller, MR Klass, MR Koelle, MS Taylor, N Ringstad, PL Larsen, RM Empson, S Brenner, S Brähler, SE Bowden, TM Ishii, VG Shakkottai, WJ Joiner   +44 more
core   +3 more sources

Diagnosis and treatment of dizziness in outpatient practice

Неврология, нейропсихиатрия, психосоматика, 2015
Objective: to study the causes of dizziness and instability in patients during an outpatient specialized appointment and to analyze and improve typical management tactics for these patients. Patients and methods.
L. M. Antonenko, N. V. Bestuzheva, V. A.
 Parfenov   +2 more
doaj   +1 more source

MELK Inhibition Effectively Suppresses Growth of Glioblastoma and Cancer Stem-Like Cells by Blocking AKT and FOXM1 Pathways

Frontiers in Oncology, 2021
Glioblastoma multiforme (GBM) is a devastating disease yet no effective drug treatment has been established to date. Glioblastoma stem-like cells (GSCs) are insensitive to treatment and may be one of the reasons for the relapse of GBM. Maternal embryonic
Xu Zhang, Xu Zhang, Xu Zhang, Jie Wang, Jie Wang, Jie Wang, Yifeng Wang, Yifeng Wang, Guanzheng Liu, Huan Li, Jiefeng Yu, Runqiu Wu, Jun Liang, Rutong Yu, Rutong Yu, Xuejiao Liu, Xuejiao Liu   +16 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Drug delivery in overcoming the blood-brain barrier: role of nasal mucosal grafting [PDF]

, 2017
The blood–brain barrier (BBB) plays a fundamental role in protecting and maintaining the homeostasis of the brain. For this reason, drug delivery to the brain is much more difficult than that to other compartments of the body. In order to bypass or cross
Carafa, Maria, Di Marzio, Luisa, Hanieh, PATRIZIA NADIA, Marianecci, Carlotta, Paolino, Donatella, Rinaldi, Federica   +5 more
core   +1 more source

Hydrotherapy in nervous system diseases

Pedagogy and Psychology of Sport, 2019
SUMMARY Hydrotherapy is one method used in the rehabilitation treatment of various diseases, including diseases of the nervous system with a positive result. It is used in many exercise programs. It has been shown that hydrotherapy reduces the clinical symptoms of the nervous system diseases, reduces pain and improves quality of life.
openaire   +6 more sources