Results 111 to 120 of about 458,582 (324)

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Homologous vs. homocratic neurons: revisiting complex evolutionary trajectories

Frontiers in Cell and Developmental Biology, 2023
Leonid L. Moroz, Leonid L. Moroz, Daria Y. Romanova   +2 more
doaj   +1 more source

Reafference and the origin of the self in early nervous system evolution. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2021
Jékely G, Godfrey-Smith P, Keijzer F.
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Evolution of highly pathogenic H5N1 influenza A virus in the central nervous system of ferrets

, 2023
Jurre Y. Siegers, Lucas M. Ferreri, Dirk Eggink, Edwin J. B. Veldhuis Kroeze, Aartjan J.W. te Velthuis, Marco van de Bildt, Lonneke Leijten, Peter van Run, Dennis de Meulder, Theo M. Bestebroer, Mathilde Richard, Thijs Kuiken, Anice C. Lowen, Sander Herfst, Debby van Riel   +14 more
openalex   +2 more sources

What is Quantum? Unifying Its Micro-Physical and Structural Appearance

, 2014
We can recognize two modes in which 'quantum appears' in macro domains: (i) a 'micro-physical appearance', where quantum laws are assumed to be universal and they are transferred from the micro to the macro level if suitable 'quantum coherence ...
A Aspect, A Einstein, A Khrennikov, AY Khrennikov, C Piron, D Aerts, D Aerts, D Aerts, D Aerts, D Aerts, D Aerts, D Aerts, D Aerts, D Aerts, D Aerts, D Aerts, D Aerts, D Aerts, D Aerts, D Aerts, D d’Enterria, D Salart, D Widdows, E Haven, EM Pothos, EN Dzhafarov, F London, GW Mackey, H Rauch, J Bardeen, JA Hampton, JD Plumhof, JR Busemeyer, JR Busemeyer, JS Bell, K Rijsbergen Van, L Broglie de, M Arndt, M Melucci, M Sarovar, M Tomasello, MA Nielsen, MH Anderson, P Kapitza, S Gerlich, S Sozzo, W Tittel, Z Wang   +47 more
core   +1 more source

A gene catalogue of the amphioxus nervous system

International Journal of Biological Sciences, 2006
The elaboration of extremely complex nervous systems is a major success of evolution. However, at the dawn of the post-genomic era, few data have helped yet to unravel how a nervous system develops and evolves to complexity.
Èlia Benito-Gutiérrez
doaj  

Profiling cellular diversity in sponges informs animal cell type and nervous system evolution. [PDF]

Science, 2021
Musser JM, Schippers KJ, Nickel M, Mizzon G, Kohn AB, Pape C, Ronchi P, Papadopoulos N, Tarashansky AJ, Hammel JU, Wolf F, Liang C, Hernández-Plaza A, Cantalapiedra CP, Achim K, Schieber NL, Pan L, Ruperti F, Francis WR, Vargas S, Kling S, Renkert M, Polikarpov M, Bourenkov G, Feuda R, Gaspar I, Burkhardt P, Wang B, Bork P, Beck M, Schneider TR, Kreshuk A, Wörheide G, Huerta-Cepas J, Schwab Y, Moroz LL, Arendt D.   +36 more
europepmc   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source