Results 81 to 90 of about 458,582 (324)

Functional structure and dynamics of the human nervous system [PDF]

, 1981
The status of an effort to define the directions needed to take in extending pilot models is reported. These models are needed to perform closed-loop (man-in-the-loop) feedback flight control system designs and to develop cockpit display requirements ...
Lawrence, J. A.
core   +1 more source

Evolution of experimental design and research techniques in HIV-1 reservoir studies : a systematic review

, 2020
Although HIV-1 has evolved from a deadly to a chronic disease over the past 20 years, an HIV-1 cure is still lacking due to the presence of persisting cellular viral reservoirs which are spread throughout the body in different anatomical compartments ...
De Scheerder, Marie-Angélique, Depelseneer, Bram, Vandekerckhove, Linos, Wim, Trypsteen   +3 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Filming the Glial Dreams: Real-Time Imaging of Cannabinoid Receptor Trafficking in Astrocytes

ASN Neuro, 2009
How does the brain process incoming information and produce thoughts? These questions represent, to all likelihood, the most challenging matters ever faced by natural sciences, matters which may never be fully comprehended.
Alexei Verkhratsky
doaj   +1 more source

Expression of Distal-less, dachshund, and optomotor blind in Neanthes arenaceodentata (Annelida, Nereididae) does not support homology of appendage-forming mechanisms across the Bilateria [PDF]

, 2010
The similarity in the genetic regulation of arthropod and vertebrate appendage formation has been interpreted as the product of a plesiomorphic gene network that was primitively involved in bilaterian appendage development and co-opted to build ...
A Abzhanov, A Caracciolo, A Hejnol, A Hidalgo, A Horner, A Minelli, A Minelli, A Saudemont, A Schmidt-Rhaesa, A Wallberg, AD Chipman, AS Denes, B Hausdorf, B Mittmann, B Prud’homme, B Rhode, C Nielsen, Christopher J. Winchell, CJ Tabin, CJ Winchell, CL Hughes, CM Heuer, CM Heuer, CW Dunn, D Arendt, DA Dorsett, DA Dorsett, David K. Jacobs, DK Jacobs, DK Jacobs, DR Angelini, DR Angelini, DR Maddison, DW Golding, DW Stock, E Abouheif, EC Seaver, EC Seaver, F Ronquist, G Aspöck, G Balavoine, G Campbell, G Giribet, G Mardon, G Panganiban, G Panganiban, G Panganiban, G Scholtz, G Scholtz, G Scholtz, GA Wray, GF Striedter, GO Pflugfelder, GP Wagner, J Felsenstein, J Mallatt, J Mallatt, J Paps, J Paps, JD Thompson, JE Smith, JH Imai, JI Hamaker, JI Pueyo, JJ Gibson-Brown, Jonathan E. Valencia, K Bell, KJ Sepp, KL Hammond, KL Hammond, KS Pappu, L Maves, L Orrhage, L Orrhage, M Kulakova, M Qiu, M Schoppmeier, MJ Bastiani, MJ Telford, N Dray, N Gorfinkiel, N Shubin, N Shubin, N-M Prpic, N-M Prpic, N-M Prpic, N-M Prpic, NJ Strausfeld, NT Takaesu, P Dollé, R Abascal, R Desper, R Janssen, R Janssen, R Kirsch, R Tomer, RF Robledo, RJ Davis, S Candiani, S Guindon, S Nissim, SB Carroll, SF Altschul, SM Cohen, SM Cohen, SM Farris, SQ Irvine, SQ Irvine, SR Martini, T Bartolomaeus, T Kojima, TA Heanue, TA Williams, TH Bullock, W Arthur, W Sewell, W Westheide, WJ Brook, WJ Dickinson, X Yang, Y Boilly-Marer, Y Inoue, Y Inoue, Y Kida, Z Kozmik, Z Kozmik   +125 more
core   +4 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

By Reverence, Not Fear: Prestige, Religion, and Autonomic Regulation in the Evolution of Cooperation

Frontiers in Psychology, 2019
Recent evolutionary theories of religions emphasize their function as mechanisms for increasing prosociality. In particular, they claim that fear of supernatural punishment can be adaptive when it can compensate for humans’ inability to monitor behavior ...
Hillary L. Lenfesty, Hillary L. Lenfesty, Thomas J. H. Morgan, Thomas J. H. Morgan   +3 more
doaj   +1 more source

Can One Make Any Crash Prediction in Finance Using the Local Hurst Exponent Idea?

, 2003
We apply the Hurst exponent idea for investigation of DJIA index time-series data. The behavior of the local Hurst exponent prior to drastic changes in financial series signal is analyzed.
Ausloos, Ausloos, Baillie, Baillie, Baviera, Buldyrev, D Grech, De Lima, Ding, Fama, Granger, Ivanova, Liu, Lux, Mandelbrot, Muller, Pagan, Peng, Peng, Plerou, Stanley, Stanley, Vandewalle, Vandewalle, Z Mazur   +24 more
core   +1 more source

Evidence for dynamic and multiple roles for huntingtin in Ciona intestinalis [PDF]

, 2013
Although mutations in the huntingtin gene (HTT) due to poly-Q expansion cause neuropathology in humans (Huntington's disease; HD), the normal function(s) of the gene and its protein (HTT) remain obscure.
Brown, Euan R., Idris, Mohammed M, Thorndyke, Michael C   +2 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source