Results 101 to 110 of about 107,393 (252)

HD‐tDCS Restores Perivascular AQP4 Polarization via PPARγ Modulation to Enhance Glymphatic Clearance After Intracerebral Hemorrhage in Mice

Advanced Science, EarlyView.
HD‐tDCS promotes recovery after intracerebral hemorrhage by enhancing PPARγ‐dependent astrocyte remodeling in a mouse model of ICH. This process suppresses proinflammatory astrocytic activation, restores perivascular AQP4 repolarization, and improves glymphatic influx and efflux, thereby facilitating hematoma and perihematomal edema clearance and ...
Zhiming Li, Yingmei Zhang, Qianqian Tong, Zhitao Gong, Shanyu Zhang, Zhen Qian, Hui Zhang, Qian Yao, Qi Li   +8 more
wiley   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Comparative Study on Physicochemical Properties, Stability and Bioavailability of All-E and Z-Astaxanthin Nano-emulsions

Shipin gongye ke-ji
To explore the physicochemical characteristics, stability and bioavailability of two geometric isomers of astaxanthin encapsulated by nano-emulsion, in this study, all-E astaxanthin nano-emulsions (all-E-AST NEs) and Z-astaxanthin nano-emulsions (Z-AST ...
Lesong ZHOU, Jialing CHEN, Liping HE, Yong CAO, Jie XIAO, Xiaojuan LIU   +5 more
doaj   +1 more source

Breda Ginnekenstraat 125. Inventariserend Veldonderzoek d.m.v. proefsleuven: BR-517-18

In opdracht van Tablinium Maastricht BV heeft team Erfgoed van de gemeente Breda een inventariserend veldonderzoek door middel van proefsleuven (IVO-P) uitgevoerd op 24 mei 2018 en van 13 tot en met 15 augustus 2018 op het achtererf van de Ginnekenstraat
Nes, E. de
core   +1 more source

Multifunctional Manganese Oxide Nanocomposite Hydrogel With Synergistic Reactive Oxygen Species‐Scavenging, Oxygen‐Generating, Immunomodulatory, and Photothermal Antimicrobial Activities for Enhanced Diabetic Wound Healing

Advanced Science, EarlyView.
CFP/PC@MnO2 hydrogel integrates ROS scavenging, oxygen delivery, oxidative stress reduction, immunomodulation, and photothermal antibacterial properties. The incorporation of PC@MnO2 NPs endows the hydrogel with multiple functional advantages tailored to the pathological microenvironment of diabetic wounds, including efficient ROS clearance, mitigation
Zhi Xu, Xiaodong Luo, Jingxian Wu, Chaoyang Huang, Zhuoying Yang, Yixiang HePeng, Bosong Zhou, Xiang Li, Ruiyuan Liu, Xu Wu   +9 more
wiley   +1 more source

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Optimal management of night eating syndrome: challenges and solutions

Neuropsychiatric Disease and Treatment, 2015
Suat Kucukgoncu, Margaretta Midura, Cenk Tek Department of Psychiatry, Yale University, New Haven, CT, USA Abstract: Night Eating Syndrome (NES) is a unique disorder characterized by a delayed pattern of food intake in which recurrent episodes of ...
Kucukgoncu S, Midura M, Tek C
doaj  

Night-eating syndrome is associated with food consumption frequency among Chinese college students

Scientific Reports
Patients with night-eating syndrome (NES) exhibit circadian rhythm dysfunction and comorbidities, including insomnia, anxiety, and depression. Therefore, understanding its potential risks and consequences is crucial.
Zixuan Hao, Xiaoqin Guo, Qi Jing, Boyang Zhao, Mengyi Huang, Zhongyu Ren   +5 more
doaj   +1 more source

Australian Fables

, 2009
Here are thirty two-page fables, each presenting a few paragraphs of prose on the left-hand page and a full-page colored illustration on the right-hand page. The texts are original and creative. All have to deal with native Australian fauna.
Jensz, Ron, Nes, Anneke
core  

Rocket‐Inspired Sequentially Targeted Nanotherapeutics for Mitochondrial Regulation and Inflammatory Reprogramming in Ischemic Stroke

Advanced Science, EarlyView.
A novel neutrophil‐hitchhiking, rocket‐inspired nanoplatform is developed to cross the blood‐brain barrier for sequential, spatiotemporal drug delivery. By responsive surface transformation in the ischemic penumbra, it precisely targets mitochondria to suppress Drp1‐mediated fission.
He Bai, Zihao Yong, Yang Li, Qingmin Chen, Yong Liu, Xiaomeng Guo, Fukai Li, Shicheng Tang, Zhuo Yang, Yufei Zhang, Ruwei Jie, Xiaohong Lv, Huacheng Wang, Chunming Huang, Liwei Xie, Jianqi Xiao, Qingchun Mu, Longguang Tang   +17 more
wiley   +1 more source