Results 31 to 40 of about 1,269 (164)

Linking substrate and nucleus via actin cytoskeleton in pluripotency maintenance of mouse embryonic stem cells

Stem Cell Research, 2019
Pluripotency of mouse embryonic stem cells is regulated by transcription factor regulatory networks as well as mechanical stimuli sensed by the cells.
Brit Gracy David, Hideaki Fujita, Kyota Yasuda, Kazuko Okamoto, Yulia Panina, Junya Ichinose, Osamu Sato, Masanobu Horie, Taro Ichimura, Yasushi Okada, Tomonobu M Watanabe   +10 more
doaj   +1 more source

Nesprins are mechanotransducers that discriminate epithelial–mesenchymal transition programs

Journal of Cell Biology, 2020
LINC complexes are transmembrane protein assemblies that physically connect the nucleoskeleton and cytoskeleton through the nuclear envelope. Dysfunctions of LINC complexes are associated with pathologies such as cancer and muscular disorders. The mechanical roles of LINC complexes are poorly understood.
Théophile Déjardin, Pietro Salvatore Carollo, François Sipieter, Patricia M. Davidson, Cynthia Seiler, Damien Cuvelier, Bruno Cadot, Cecile Sykes, Edgar R. Gomes, Nicolas Borghi   +9 more
openaire   +4 more sources

SIRT2 Inhibition by AGK2 Promotes Perinuclear Cytoskeletal Organisation and Reduces Invasiveness of MDA-MB-231 Triple-Negative Breast Cancer Cells in Confined In Vitro Models

Cells
Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype characterised by the absence of targetable hormone receptors and increased metastatic rates.
Emily Jessop, Natalie Young, Beatriz Garcia-Del-Valle, Jack T. Crusher, Boguslaw Obara, Iakowos Karakesisoglou   +5 more
doaj   +1 more source

Nesprin-2 mediated nuclear trafficking and its clinical implications [PDF]

Nucleus, 2015
Nuclear translocation of proteins has a crucial role in the pathogenesis of cancer, Alzheimer disease and viral infections. A complete understanding of nuclear trafficking mechanisms is therefore necessary in order to establish effective intervention strategies.
Kelkar, Pranav, Walter, Anna, Papadopoulos, Symeon, Mroß, Carmen, Munck, Martina, Peche, Vivek S, Noegel, Angelika A   +6 more
openaire   +2 more sources

Micro Pattern‐Based 3D Cell Culture Platform: An Overview of Technologies and Applications

Exploration, EarlyView.
Micro patterns are characterized as a coating of specific adhesion matrices on substrates to support cell growth. An overview of micropattern technology to regulate single cell morphology and fates, further focusing on the micro pattern‐based 3D cell culture platform used in the non‐tumor and tumor researches.
Xinglong Zhu, Yi Li, Hulin Long, Yijia Wu, Ningwei Sun, Shun Li, Yiyao Liu, Huiqi Xie, Ji Bao   +8 more
wiley   +1 more source

Mutations in LMNA modulate the lamin A--Nesprin-2 interaction and cause LINC complex alterations.

PLoS ONE, 2013
BackgroundIn eukaryotes the genetic material is enclosed by a continuous membrane system, the nuclear envelope (NE). Along the NE specific proteins assemble to form meshworks and mutations in these proteins have been described in a group of human ...
Liu Yang, Martina Munck, Karthic Swaminathan, Larisa E Kapinos, Angelika A Noegel, Sascha Neumann   +5 more
doaj   +1 more source

Using Nesprin Tension Sensors to Measure Force on the LINC Complex [PDF]

, 2018
Mechanotransduction, or the process by which mechanical forces regulate cellular functions, is increasingly studied in a variety of different physiological and pathological contexts. Although these forces are most often studied at cell-matrix and cell-cell adhesions, recent work has shown that the nuclear LINC complex is also subject to mechanical ...
Paul T. Arsenovic, Daniel E. Conway
openalex   +4 more sources

The nesprin–IF connection

The Journal of Cell Biology, 2005
![Graphic][1] Nesprin-3 (green) recruits plectin (red) to the nuclear perimeter, where it connects to keratins (blue).The nucleus is linked to the cytoplasmic intermediate filament (IF) network, say Wilhelmsen et al.
openaire   +2 more sources

Cardiovascular Involvement in SYNE Variants: A Case Series and Narrative Review

Cardiogenetics
Cardiac laminopathies encompass a wide range of diseases caused by defects in nuclear envelope proteins, including cardiomyopathy, atrial and ventricular arrhythmias and conduction system abnormalities.
Francesco Ravera, Veronica Dusi, Pier Paolo Bocchino, Giulia Gobello, Giuseppe Giannino, Daniele Melis, Giulia Margherita Brach Del Prever, Filippo Angelini, Andrea Saglietto, Carla Giustetto, Guglielmo Gallone, Stefano Pidello, Margherita Cannillo, Marco Matteo Cingolani, Silvia Deaglio, Walter Grosso Marra, Gaetano Maria De Ferrari, Claudia Raineri   +17 more
doaj   +1 more source

A201 Initial Adhesion of Nesprin-1 Knocked-down Fibroblasts

The Proceedings of the JSME Conference on Frontiers in Bioengineering, 2013
Mai Ogawa, Takamitsu Kishimoto, Naoya Sakamoto   +2 more
openalex   +2 more sources