Results 51 to 60 of about 1,269 (164)

Nesprin proteins: bridging nuclear envelope dynamics to muscular dysfunction. [PDF]

Cell Commun Signal
AbstractThis review presents a comprehensive exploration of the pivotal role played by the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex, with a particular focus on Nesprin proteins, in cellular mechanics and the pathogenesis of muscular diseases. Distinguishing itself from prior works, the analysis delves deeply into the intricate interplay
Zi-Yi Z, Qin Q, Fei Z, Cun-Yu C, Lin T.
europepmc   +4 more sources

Targeted Ablation of Nesprin 1 and Nesprin 2 from Murine Myocardium Results in Cardiomyopathy, Altered Nuclear Morphology and Inhibition of the Biomechanical Gene Response

PLoS Genetics, 2014
Recent interest has focused on the importance of the nucleus and associated nucleoskeleton in regulating changes in cardiac gene expression in response to biomechanical load. Mutations in genes encoding proteins of the inner nuclear membrane and nucleoskeleton, which cause cardiomyopathy, also disrupt expression of a biomechanically responsive gene ...
Indroneal Banerjee, Jianlin Zhang, Thomas Moore‐Morris, Emily Pfeiffer, Kyle S. Buchholz, Ao Liu, Kunfu Ouyang, Matthew J. Stroud, Larry Gerace, Sylvia Μ. Evans, Andrew D. McCulloch, Ju Chen   +11 more
openalex   +9 more sources

Sonoepigenetic Modification Mechanoprimes Early Osteogenic Commitment in Mesenchymal Stem Cells

Advanced Science, Volume 12, Issue 47, December 18, 2025.
Brief 10 min bursts of high frequency (10 MHz) vibrational mechanostimulation to stem cells are shown to activate their epigenetic machinery to condition their differentiation down an osteogenic lineage within just 3 days, which is much earlier than that with other forms of mechanostimuli, and without requiring any biochemical additives. Abstract Cells
Lizebona A. Ambattu, Blanca del Rosal, Carmelo Ferrai, Leslie Y. Yeo   +3 more
wiley   +1 more source

Depletion of Nesprin-2 is associated with an embryonic lethal phenotype in mice [PDF]

, 2018
Carmen Mroß, Marija Marko, Martina Munck, Gernot Glöckner, Susanne Motameny, Janine Altmüller, Angelika A. Noegel, Ludwig Eichinger, Vivek S. Peche, Sascha Neumann   +9 more
  +4 more sources

Decreased RYR2 Cluster Size and Abnormal SR Ca2+ Release Contribute to Arrhythmogenesis in TMEM43‐Related ARVC

Advanced Science, Volume 12, Issue 45, December 4, 2025.
The TMEM43 ‐ P386S mutation causes arrhythmogenic right ventricular cardiomyopathy (ARVC) by mislocalizing itself from nuclear envelope (NE) to cytoplasm, disrupting lamin B2 (a novel TMEM43 interactor) localization, NE integrity and chromatin accessibility, causing hyper ‐ phosphorylation and reduced expression/clustering of ryanodine receptor type 2 (
Jiaxi Shen, Xiaochen Wang, Hangping Fan, Yaxun Sun, Tingyu Gong, Hangyuan Qiu, Jue Wang, Ziwei Pan, Yanna Dang, Hongkun Wang, Danni Zhou, Tianyi Zhu, Hao Wang, Xianzhen Chen, Lizhen Xu, Jun Su, Fan Yang, Yiquan Tang, Xuguang Li, Bing Yang, Lenan Zhuang, Wei Wang, Chenyang Jiang, Ping Liang   +23 more
wiley   +1 more source

R405W Desmin Knock‐In Mice Highlight Alterations of Mitochondria, Protein Quality Control and Myofibrils in Myofibrillar Myopathy

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Mutations in the desmin gene cause skeletal myopathies and cardiomyopathies. The objective of this study was to elucidate the molecular pathology induced by the expression of R405W mutant desmin in murine skeletal muscle. Methods A comprehensive characterization of the skeletal muscle pathology in hetero‐ and homozygous R405W desmin
Sabrina Batonnet‐Pichon, Florence Delort, Alain Lilienbaum, Carolin Berwanger, Dorothea Schultheis, Ursula Schlötzer‐Schrehardt, Andreas Schmidt, Steffen Uebe, Yosra Baiche, Tom J. Eisenack, Débora Broch Trentini, Markus Mallek, Leonid Mill, Ana Ferreiro, Bettina Eberhard, Thomas Lücke, Markus Krüger, Christian Thiel, Rolf Schröder, Christoph S. Clemen   +19 more
wiley   +1 more source

N-terminal nesprin-2 variants regulate β-catenin signalling

Experimental Cell Research, 2016
The spatial compartmentalisation of biochemical signalling pathways is essential for cell function. Nesprins are a multi-isomeric family of proteins that have emerged as signalling scaffolds, herein, we investigate the localisation and function of novel nesprin-2 N-terminal variants.
Zhang, Qiuping, Minaisah, Rose-Marie, Ferraro, Elisa, Li, Chen, Porter, Lauren J., Zhou, Can, Gao, Fang, Zhang, Junyi, Rajgor, Dipen, Autore, Flavia, Shanahan, Catherine M., Warren, Derek T.   +11 more
openaire   +6 more sources

Mechanical Signaling: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 6, Issue 12, December 2025.
In this review, we summarize cell–ECM interactions and delve into the complex mechanotransduction. We introduce advanced research methods and emerging clinical tools used to study cellular mechanical phenotypes, mechanotransduction, and disease progression. Additionally, we analyze the role of mechanical biomarkers in the development and progression of
Yicen Long, Peng Wang, Jiacheng Lei, Baihai Su, Qiang Wei, Xiaojing Liu   +5 more
wiley   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, Volume 599, Issue 20, Page 2854-2877, October 2025.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

A phenotypic screen for novel small molecules that correct tau‐mediated pathologies in human frontotemporal dementia neurons

Alzheimer's &Dementia, Volume 21, Issue 9, September 2025.
Abstract INTRODUCTION Mutations in the MAPT gene that are causal for frontotemporal dementia (FTD) lead to mislocalization of tau protein to the neuronal cell body, changing microtubule dynamics to disrupt the nuclear envelope and nucleocytoplasmic transport.
Hannah Maxwell, James Smith, Tom Campbell, Jason Clark, Rosanna La Rocca, Francesco Paonessa, Sergey Sitnikov, Mark Evans, Peter Maycox, Frederick J. Livesey   +9 more
wiley   +1 more source