Results 61 to 70 of about 1,269 (164)
Small, Volume 21, Issue 38, September 25, 2025.Nano‐pulling induces stabilization, reorganization, and reorientation of the microtubule network. The nucleus of stretched cells experiences increased lateral tension, becomes more spherical, and develops surface grooves. At the level of gene expression regulation, changes in nuclear morphology induce global chromatin remodeling, leading to reduced ...
Alessandro Falconieri +7 more
wiley +1 more source
Advanced Science, Volume 12, Issue 31, August 21, 2025.The premature aging‐related progerin leads to defective nuclear morphology and is associated with disrupted molecular coupling between the extranuclear cytoskeleton and lamin‐associated nuclear envelope. It is discovered that progerin expression reduces nuclear tension, forms nuclear wrinkling, and enhances chromatin dynamics, thereby regulating ...
Ji‐Eun Park +9 more
wiley +1 more source
Aging and Altered Gravity: A Cellular Perspective
The FASEB Journal, Volume 39, Issue 13, 15 July 2025.We propose that, unlike biological aging, where Primary hallmarks initiate damage, spaceflight may trigger a feedback loop between Antagonistic and Integrative hallmarks, driving accelerated aging. Returning to 1 g restores proper signaling and breaks the cycle.
Sharon van Rijthoven +1 more
wiley +1 more source
Ecology and Evolution, Volume 15, Issue 7, July 2025.The vast Lake Baikal in Siberia is located in a region with a continental climate, implying pronounced seasonal temperature differences. Remarkably, reproducing during the extremely cold winters when the lake is covered by a thick ice layer is a common trait in Baikal's endemic littoral amphipods.
Polina Lipaeva +6 more
wiley +1 more source
Myonuclear alterations associated with exercise are independent of age in humans
The Journal of Physiology, Volume 603, Issue 13, Page 3755-3775, 1 July 2025.Abstract figure legend Structural and mechanical properties of myonuclei in trained young and aged individuals. In skeletal muscle fibres from trained individuals, myonuclei are more spherical, have greater lamin A and are stiffer compared to untrained counterparts.
E. Battey +15 more
wiley +1 more source
P88 CARDIAC INVOLVEMENT IN FOUR NOVEL NESPRIN–1 GENETIC VARIANTS [PDF]
, 2023 R Manaï +15 more
openalex +1 more source
LINC complex protein nesprin-2 has pro-apoptotic activity via Bcl-2 family proteins [PDF]
, 2023 Reuven Stein +4 more
openalex +1 more source
Lack of a Retinal Phenotype in a Syne-2/Nesprin-2 Knockout Mouse Model [PDF]
, 2019 Nathalie Falk +7 more
openalex +1 more source
Lamins and nesprin-1 mediate inside-out mechanical coupling in muscle cell precursors through FHOD1 [PDF]
, 2017 Christine Schwartz +12 more
openalex +1 more source