Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Fumarate inhibits the formation of neutrophil extracellular traps (NETs) in a Nrf2-controlled and Annexin-A1-dependent manner associated with mitochondrial fusion. [PDF]
Burczyk G, Kolaczkowska E.
europepmc +1 more source
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
Comparison of Alternative Policy Definitions for Safety-Net Ambulatory Practices.
Liao JM +4 more
europepmc +1 more source
An intelligent segmentation method for leakage points in central serous chorioretinopathy based on fluorescein angiography images. [PDF]
Xu JG +6 more
europepmc +1 more source
The contribution rate of climate driven net primary productivity growth of vegetation has significantly increased, while human activities dominated its decrease from 1982 to 2020 in China [PDF]
Qi Chen, Wenjiao Shi, Wei Zhou
openalex +1 more source
BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru +6 more
wiley +1 more source
TFP-Net: A temporal-feature-prototypical network for CRM optimization and cold-start mitigation. [PDF]
Li Y, Dong J, Wang R.
europepmc +1 more source

