Results 141 to 150 of about 12,800,448 (216)

Microbiota-assisted screening for colorectal neoplasia: advanced adenoma as the key translational endpoint-a narrative review. [PDF]

Am J Transl Res
Wang X, Li J, Cheng Y, Liu Y, Li H, Tan H, Hu Y, Zhao M, Liu J.   +8 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Lipoic Acid Attenuates Lipopolysaccharide- and <i>Escherichia coli</i>-Induced Reactive Oxygen Species Production and Neutrophil Extracellular Trap Formation Without Impairing <i>Escherichia coli</i> or <i>Staphylococcus aureus</i> Killing by Human Neutrophils. [PDF]

Int J Mol Sci
Valencia-Hernández GA, Fafutis-Morris M, Godínez-Méndez LA, Muñoz-Sánchez G, Martínez-Barajas MG, García-Contreras AA, Íñiguez-Gutiérrez L, Delgado-Rizo V.   +7 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

<i>Porphyromonas gingivalis</i> outer membrane vesicles induce an activated but permissive neutrophil phenotype. [PDF]

Front Immunol
Fretes A, Lara B, Calo G, Rojas Campión I, Materazzi L, Sabbione F, Robaldi SA, Pautasso MC, Pérez Leirós C, Vota D, Tribelli PM, Hauk V.   +11 more
europepmc   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

A comprehensive plasma-based approach to thromboinflammation in bladder cancer: integrating lipidomics, thrombin generation, and NETosis biomarkers. [PDF]

J Transl Med
Oto J, Herreros-Pomares A, Verger P, Herranz R, Plana E, Roca M, Pérez-Ardavín J, Vera-Donoso CD, Martínez-Sarmiento M, Bonanad S, Medina P.   +10 more
europepmc   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Bridging linguistic reasoning and biophysical reality toward peptide engineering via instruction-tuned language modeling. [PDF]

Bioinformatics
Yang K, Wu T, Zhang W, Li P.
europepmc   +1 more source