Results 141 to 150 of about 16,134,501 (283)
A Study on the Judgmental Factors of Business Value in the Phalaenopsis industry in Taiwan
, 2009 [[abstract]]The Phalaenopsis industry in Taiwan has already transformed form a traditional agriculture industry to a bio-technology based one, which can be grouped as knowledge, technique intensive industry, and the industry of the capital-intensive is ...
Tsai Bing-Reui
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
(Expected) value-based payment: From total cost of care to net present value of care. [PDF]
Healthc (Amst), 2019 Counts NZ, Smith JD, Crowley DM.
europepmc +1 more source
Fuzzy numbers and net present value
Net present value is a very common criterion in capital budgeting processes. Usually, uncertainty is treated by means of probability theory and net cash flows are included in the model as random variables. Nevertheless, the lack of accuracy in estimation
Gutiérrez, Isabel
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On the use of copula for calculating the present value of a general cash flow. [PDF]
present value; Value;
Darkiewicz, Grzegorz +4 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Employing Real Options Methodology for Decision Making in Greenhouse Technology [PDF]
Latest developments in investment analysis offer a number of valuable insights into how to evaluate investment opportunities encountering the weaknesses of net present value criterion.
Tzouramani, Irene, Mattas, Konstadinos
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source