Results 171 to 180 of about 577,979 (302)

Strengthening equitable research capacity in response to infectious diseases of poverty. [PDF]

BMJ Glob Health
Asampong E, Echavarria Mejia MI, Mahendradhata Y, Vahedi M, Thorson A.   +4 more
europepmc   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Prioritising opportunities to strengthen the maternal, newborn, and child health research ecosystem in Ethiopia: a Delphi exercise. [PDF]

J Glob Health
Taddesse L, Korte ML, Hunegnaw BM, Teklie H, Bekele D, Tolera G, Zelalem M, Chan GJ.   +7 more
europepmc   +1 more source

Understanding the long-term impacts of the EU framework programme of research and technological development [PDF]

, 2011
Arnold, Erik
core   +1 more source

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Top 10 research priorities for adolescent and young adult cancer in Canada: a James Lind Alliance priority setting partnership. [PDF]

BMJ Open
Tutelman PR, Thurston C, Ranger T, Rader T, Henry B, Abdelaal M, Blue M, Buckland TW, Del Gobbo S, Dobson L, Gallant E, Heykoop C, Jansen M, Larsen L, Maseja N, Oberoi S, Ramasamy V, Smith M, Wendowsky N, Beattie S, Bender JL, Birnie K, Garland SN, Jibb L, Noel M, Schulte FSM.   +25 more
europepmc   +1 more source

INB3P: A Multi‐Modal and Interpretable Co‐Attention Framework Integrating Property‐Aware Explanations and Memory‐Bank Contrastive Fusion for Blood–Brain Barrier Penetrating Peptide Discovery

Advanced Science, EarlyView.
INB3P is a multimodal framework for blood–brain barrier‐penetrating peptide prediction under extreme data scarcity and class imbalance. By combining physicochemical‐guided augmentation, sequence–structure co‐attention, and imbalance‐aware optimization, it improves predictive performance and interpretability.
Jingwei Lv, Qianyang Wu, Jian Liu, Binlu Yang, Yuanhao Li, Junlin Xu, Yajie Meng, Leyi Wei, Zilong Zhang, Quan Zou, Xiulai Li, Feifei Cui   +11 more
wiley   +1 more source

Cybersecurity in connected medical devices: a policy agenda for the NHS. [PDF]

NPJ Digit Med
Toparti O, Rajput K, Darzi A, Ghafur S.
europepmc   +1 more source

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

Advanced Science, EarlyView.
It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou, Xi Zhang, Sihan Chen, Mengchi Yu, Yilan Hu, Chi Gan, Xianghu Meng, Long Li, Ninghong Song   +8 more
wiley   +1 more source

Identifying local priorities for research with linked routine data: an online workshop method. [PDF]

Int J Popul Data Sci
Henderson H, Bridges S, Bryant M, Ciesla K, Pickett K.   +4 more
europepmc   +1 more source