Results 71 to 80 of about 152,325 (279)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
IET Cyber-Physical Systems, 2018 Energy Internet (EI) is a revolution of power systems due to its flexible energy control. The smart meters are the key components in EI which perform real-time monitoring and require high demands on quality of services (QoSs).
Lina Huang +5 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
IEEE Access, 2018 As the proportion of information content in the power grid increased, information-centric smart grid (iCenS) has drawn much attention in recent years. By introducing features of information-centric networking on decentralization, multi-path transmission,
Kuan Wang, Jianhua Li, Jun Wu, Gaolei Li
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Application of network calculus to analyze eCPRI traffic delays in 4G/5G fronthaul mobile networks
Учёные записки Казанского университета: Серия Физико-математические наукиNetwork calculus provides a mathematical framework for determining the delay bounds in network models and, unlike the queueing theory which relies on the distribution functions of random variables, uses simple deterministic parameters describing the ...
A. V. Roslyakov, V. V. Gerasimov
doaj +1 more source
Argument Calculus and Networks [PDF]
, 1993 A major reason behind the success of probability calculus is that it possesses a number of valuable tools, which are based on the notion of probabilistic independence. In this paper, I identify a notion of logical independence that makes some of these tools available to a class of propositional databases, called argument databases.
openaire +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source