Results 71 to 80 of about 1,291,783 (267)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Safety Design of Network Control System in High-speed Train

open access: yes机车电传动, 2014
Safety requirements and safety design hierarchy of high-speed train network control system were introduced. RAMSengineer was briefly stated. Safety design of the high-speed train network control system were well described from safety requirement ...
YANG Wei-feng   +2 more
doaj  

Projective Synchronization for a Class of Fractional-Order Chaotic Systems with Fractional-Order in the (1, 2) Interval

open access: yesEntropy, 2015
In this paper, a projective synchronization approach for a class of fractional-order chaotic systems with fractional-order 1 < q < 2 is demonstrated. The projective synchronization approach is established through precise theorization. To illustrate
Ping Zhou, Rongji Bai, Jiming Zheng
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

Controllability of Networked Sampled-Data Systems

open access: yesIEEE Transactions on Automatic Control
The controllability of networked sampled-data systems with zero-order holders on the control and transmission channels is explored, where single- and multi-rate sampling patterns are considered, respectively. The effects of sampling on the controllability of networked systems are analyzed, with some necessary and/or sufficient controllability ...
Zixuan Yang 0002   +2 more
openaire   +3 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Design of CRH2 EMUs Control System Redundant Safety

open access: yes机车电传动, 2019
Aiming at the characteristics of high safety and reliability of the CRH2 EMUs vehicle control system, the communication architecture of network control system, software and hardware control platform and vehicle electrical control system was studied.
Qunxin LIU, Fang HUO
doaj  

A Novel Hybrid Function Projective Synchronization between Different Fractional-Order Chaotic Systems

open access: yesDiscrete Dynamics in Nature and Society, 2011
An adaptive hybrid function projective synchronization (AHFPS) scheme between different fractional-order chaotic systems with uncertain system parameter is addressed in this paper.
Ping Zhou, Xiao-You Yang
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

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