Results 91 to 100 of about 4,643,840 (321)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Designing an Urban Air Mobility Corridor Network: A Multi-Objective Optimization Approach Using U-NSGA-III

open access: yesAerospace
The corridor network serves as an effective solution for the airspace structure safety design of UAM. However, current studies rarely account for the ground risk posed by the corridor operation and typically consider a single design objective with ...
Zhiyuan Zhang   +4 more
doaj   +1 more source

Software tools for a multilayer network design

open access: yesJournal of Telecommunications and Information Technology, 2005
Today’s long haul and metro high-speed networks are mainly based on synchronous digital hierarchy (SDH) or its American equivalent synchronous optical network (SONET) and wavelength division multiplex (WDM).
Holger Holler, Stefan Voß
doaj   +1 more source

2D CONVOLUTIONAL NEURAL NETWORK IN THE DESIGN OF MONOLITHIC SELFSTRESSED SLABS ON BASE

open access: diamond, 2023
А. Е. Желткович   +4 more
openalex   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

The Budgeted Labeled Minimum Spanning Tree Problem

open access: yesMathematics
In order to reduce complexity when designing multi-media communication networks, researchers often consider spanning tree problems defined on edge-labeled graphs.
Raffaele Cerulli   +3 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

open access: yesMolecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster   +3 more
wiley   +1 more source

Joint MMSE Transceiver Design for Downlink Heterogeneous Network

open access: yes, 2018
In this paper, we propose a minimum mean square error (MMSE) based transceiver design scheme for a downlink multiple-input multiple-output (MIMO) two-tier heterogeneous network with general linear equality per-cell power constraints.
Li, Zhannan, Lu, I-Tai, Yan, Hangsong
core   +1 more source

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