Results 91 to 100 of about 1,202,845 (261)
Designing a Rational Distribution Network for Trading Companies
Transport and Telecommunication, 2017 This article considers the modern methods and approaches to design the company’s distribution network. The authors point out the relevance of this problem for the modern trading and manufacturing companies, give examples of the strategic goal setting of ...
Dybskaya V. V., Sverchkov P. A.
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Prepositioning network design for humanitarian relief purposes under correlated demand uncertainty. [PDF]
Comput Ind Eng, 2023 Zhang X, Chen D.
europepmc +2 more sources
Solution Algorithms for the Capacitated Location Tree Problem with Interconnections
AlgorithmsThis paper addresses the Capacitated Location Tree Problem with Interconnections, a new combinatorial optimization problem with applications in network design.
Nidia Mendoza-Andrade +2 more
doaj +1 more source
Quantum computing for transport network design problems. [PDF]
Sci Rep, 2023 Dixit VV, Niu C.
europepmc +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Sustainable road network design considering hydrogen fuel cell vehicles. [PDF]
Sci Rep, 2023 Liu H.
europepmc +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source