Results 81 to 90 of about 14,482,155 (299)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Reconnecting through Digital Making [PDF]

, 2013
'Making stuff' in an educational setting has been an integral part of learning for Product Design since programs were first developed. Sketch modelling and prototype making have been fundamental to the working practice of professional product designers (
Canning, Sam, Loy, J, Canning, S, Loy, Jennifer   +3 more
core  

Closed-Loop Supply Chain Network with Green Supplier Selection and Disassembly of Products: A Bi-Objective Model [PDF]

International Journal of Research in Industrial Engineering, 2013
This paper aims to study the impact of product greenness and part reliability on reverse supply chain network through green supplier selection and disassembly of products.
S. Ghayebloo, M.J. Tarokh, M. Abedzadeh
doaj  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Network processor design.

, 2005
The past few years have seen significant change in the landscape of high-end network processing. In response to the formidable challenges facing this emerging field, the editors of this series set out to survey the latest research and practices in the ...
Franklin, Mark A.
core  

Designing an Urban Air Mobility Corridor Network: A Multi-Objective Optimization Approach Using U-NSGA-III

Aerospace
The corridor network serves as an effective solution for the airspace structure safety design of UAM. However, current studies rarely account for the ground risk posed by the corridor operation and typically consider a single design objective with ...
Zhiyuan Zhang, Yuan Zheng, Chenglong Li, Bo Jiang, Yichao Li   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The Budgeted Labeled Minimum Spanning Tree Problem

Mathematics
In order to reduce complexity when designing multi-media communication networks, researchers often consider spanning tree problems defined on edge-labeled graphs.
Raffaele Cerulli, Ciriaco D'Ambrosio, Domenico Serra, Carmine Sorgente   +3 more
doaj   +1 more source

A Network Design Problem

, 2009
We consider the problem of designing a distribution network to facilitate the repeated movement of shipments from many origins to many destinations. A sufficient number of the origin-destination shipments require less than the capacity of a vehicle, so that consolidation of shipments is economical.
Kleywegt, Anton J., Lee, Jinpyo, Ward, Amy R.   +2 more
openaire   +4 more sources