Results 91 to 100 of about 14,482,155 (299)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
We are Never Naked. Insulation as a Performing Surface
, 2018 In May 1987, an assorted group of thirty-three participants—including fashion and textile designers, academics, and practitioners—gathered to explore fashion and design practices as a function of time, through an intensive 12-day workshop held at the ...
Kousidi, Matina +5 more
core
Software tools for a multilayer network design
Journal of Telecommunications and Information Technology, 2005 Today’s long haul and metro high-speed networks are mainly based on synchronous digital hierarchy (SDH) or its American equivalent synchronous optical network (SONET) and wavelength division multiplex (WDM).
Holger Holler, Stefan Voß
doaj +1 more source
Hierarchical Ring Network design
Theory of Computing Systems, 2003 A hierarchical ring network is obtained from a ring network by appending at most one subsidiary ring to each node of the ring and, recursively, to each node of each subsidiary ring. The depth d is the number of levels of the recursive appending of subsidiary rings.
Bermond, Jean-Claude +2 more
openaire +5 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Designing a Sustainable Closed-Loop Supply Chain Network of Automobile Tires Using a Multi-Objective Mathematical Programming Approach: A Case Study [PDF]
مطالعات مدیریت توسعه سبزIn this research, in order to increase the efficiency of the proposed supply chain network, a multi-product model with multiple objectives has been considered simultaneously. This model is designed to include four levels (supply, production, distribution,
Mohammad Reza Fathi +3 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source