Results 71 to 80 of about 1,222,668 (263)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Closed-Loop Supply Chain Network with Green Supplier Selection and Disassembly of Products: A Bi-Objective Model [PDF]
International Journal of Research in Industrial Engineering, 2013 This paper aims to study the impact of product greenness and part reliability on reverse supply chain network through green supplier selection and disassembly of products.
S. Ghayebloo, M.J. Tarokh, M. Abedzadeh
doaj
Communications of the Association for Information Systems, 2015 Trust networks can be used to find trustworthy information, people, products and services on public networks. Hence, they have the potential to combine the advantages of search, recommendation systems, and social networks. But proper design and correct incentives are critical to the success of such networks.
openaire +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Software tools for a multilayer network design
Journal of Telecommunications and Information Technology, 2005 Today’s long haul and metro high-speed networks are mainly based on synchronous digital hierarchy (SDH) or its American equivalent synchronous optical network (SONET) and wavelength division multiplex (WDM).
Holger Holler, Stefan Voß
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
AerospaceThe corridor network serves as an effective solution for the airspace structure safety design of UAM. However, current studies rarely account for the ground risk posed by the corridor operation and typically consider a single design objective with ...
Zhiyuan Zhang +4 more
doaj +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
The Budgeted Labeled Minimum Spanning Tree Problem
MathematicsIn order to reduce complexity when designing multi-media communication networks, researchers often consider spanning tree problems defined on edge-labeled graphs.
Raffaele Cerulli +3 more
doaj +1 more source