Results 71 to 80 of about 1,267,357 (242)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Software tools for a multilayer network design

Journal of Telecommunications and Information Technology, 2005
Today’s long haul and metro high-speed networks are mainly based on synchronous digital hierarchy (SDH) or its American equivalent synchronous optical network (SONET) and wavelength division multiplex (WDM).
Holger Holler, Stefan Voß
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

A Network Design Problem

, 2009
We consider the problem of designing a distribution network to facilitate the repeated movement of shipments from many origins to many destinations. A sufficient number of the origin-destination shipments require less than the capacity of a vehicle, so that consolidation of shipments is economical.
Kleywegt, Anton J., Lee, Jinpyo, Ward, Amy R.   +2 more
openaire   +4 more sources

Hierarchical Ring Network design

Theory of Computing Systems, 2003
A hierarchical ring network is obtained from a ring network by appending at most one subsidiary ring to each node of the ring and, recursively, to each node of each subsidiary ring. The depth d is the number of levels of the recursive appending of subsidiary rings.
Bermond, Jean-Claude, Choplin, Sebastien, Pérennes, Stéphane   +2 more
openaire   +3 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Designing a Sustainable Closed-Loop Supply Chain Network of Automobile Tires Using a Multi-Objective Mathematical Programming Approach: A Case Study [PDF]

مطالعات مدیریت توسعه سبز
In this research, in order to increase the efficiency of the proposed supply chain network, a multi-product model with multiple objectives has been considered simultaneously. This model is designed to include four levels (supply, production, distribution,
Mohammad Reza Fathi, Mohammadjavad Pahlevanzadeh, Amirhossein Saffarinia, Samaneh Raesi Nafchi   +3 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Network design with grooming constraints

Electronic Notes in Discrete Mathematics, 2004
Abstract Networks are physically and logically decomposed into layers with different technological features. Often, the routing of a demand through a non-multiplexing layer is made by grooming several demands at another, multiplexing-capable layer, thus using less capacity on the former but more on the latter.
BELOTTI P., MALUCELLI, FEDERICO
openaire   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source